Meiotic Instability Generates a Pathological Condition in Mammalian Ovum

Premkumar, Karuppanan V.; Prasad, Shilpa; Tiwari, Meenakshi; Pandey, Ashutosh; Gupta, Akhil; Sharma, Alka; Yadav, Pramod K.; Yadav, Anil Kumar; Pandey, Devendra Kumar; Pandey, Ajai Kumar; Chaube, Shail K.

doi:10.1007/s12015-020-10072-z

Cited by 6 publications

(10 citation statements)

References 73 publications

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“…The destabilised MPF causes meiotic instability leading to meiotic resumption from diplotene arrest in rat oocytes (Figure 3a). 12,16,[93][94][95] The SARS-CoV-2 infection and inflammation as well as psychological stress-mediated generation of moderate levels of ROS could initiate downstream signalling pathways to modulate the meiotic cell cycle of follicular oocyte. This possibility is strengthened by observations that moderate increase of ROS under the physiological range interact with cytosolic free Ca 2þ level and destabilise MPF required for meiotic exit from diplotene arrest in rat oocytes cultured in vitro.…”

Section: Ros Generates Meiots Ic Instability In Follicular Oocytementioning

confidence: 99%

“…[96][97][98] Similar to meiotic exit from diplotene arrest, excess levels of ROS elevate cytosolic free Ca 2þ level and destabilise MPF complex during abortive spontaneous activation in rat oocytes after ovulation (Figure 3b). 16,93,96,97 Accumulation of excess levels of ROS beyond the physiological level may inhibit spontaneous meiotic resumption and thereby meiotic maturation of follicular oocytes in rat. 12,99,100 These possibilities are supported by the observations that increase of ROS YADAV ET AL.…”

Section: Ros Generates Meiots Ic Instability In Follicular Oocytementioning

confidence: 99%

“…The increased ROS level in the follicular fluid interact with other major signal molecules to modulate oocyte physiology. [91][92][93] Studies suggest that ROS interact with 3 0 ,5 0 -cyclic adenosine monophosphate (cAMP) and calcium ion (Ca 2þ ) of the oocyte to initiate downstream signalling pathways. Changes in the levels of these signal molecules modulate phosphorylation/dephosphorylation of Cdk1, a catalytic unit of maturation promoting factor (MPF) as well as cyclin B1, a regulatory unit of MPF.…”

Section: Ros Generates Meiots Ic Instability In Follicular Oocytementioning

confidence: 99%

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Follicular oocyte as a potential target for severe acute respiratory syndrome coronavirus 2 infection

Yadav,

Pandey,

Premkumar

et al. 2024

Reviews in Medical Virology

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Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) was reported in December 2019 and rapidly became a pandemic as coronavirus disease 2019 (COVID‐19). Apart from other organs, presence of specific receptor angiotensin‐converting enzyme (ACE2) and corresponding proteases such as transmembrane serine protease 2, basigin and cysteine protease cathepsin L make follicular somatic cells as well as oocyte as potential targets for SARS‐CoV‐2 infection. The SARS‐CoV‐2 causes inflammation and hypoxia that generate reactive oxygen species (ROS) in critically ill patients. In addition, a large number of casualties and insecurity of life due to repeated waves of SARS‐CoV‐2 infection generate psychological stress and cortisol resulting in the further generation of ROS. The excess levels of ROS under physiological range cause meiotic instability, while high levels result in oxidative stress that trigger various death pathways and affect number as well as quality of follicular oocytes. Although, emerging evidence suggests that the SARS‐CoV‐2 utilises cellular machinery of ovarian follicular cells, generates ROS and impairs quality of follicular oocytes, the underlying mechanism of viral entry into host cell and its negative impact on the follicular oocyte remains poorly understood. Therefore, this review summarises emerging evidence on the presence of cellular machinery for SARS‐CoV‐2 in ovarian follicles and the potential negative impact of viral infection on the follicular oocytes that affect ovarian functions in critically ill and stressed women.

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Section: Ros Generates Meiots Ic Instability In Follicular Oocytementioning

confidence: 99%

Section: Ros Generates Meiots Ic Instability In Follicular Oocytementioning

confidence: 99%

Section: Ros Generates Meiots Ic Instability In Follicular Oocytementioning

confidence: 99%

See 1 more Smart Citation

Follicular oocyte as a potential target for severe acute respiratory syndrome coronavirus 2 infection

Yadav,

Pandey,

Premkumar

et al. 2024

Reviews in Medical Virology

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“…It is reported that high level of activated MPF (cyclinB1/CDK1) is important for the initiation of oocyte meiotic resumption and the maintenance of MII arrest until fertilization 161 . Moreover, the maintenance of oocyte MII arrest is essential for successful fertilization 164 . Phosphorylated WEE1/MYT1 by PKA mediates that the phosphorylation of CDK1 at Thr14 and Tyr15 and is responsible for the maintenance of the inactive form of MPF.…”

Section: Non‐histone Protein Post‐translational Modifications In Mztmentioning

confidence: 99%

“… 161 Moreover, the maintenance of oocyte MII arrest is essential for successful fertilization. 164 Phosphorylated WEE1/MYT1 by PKA mediates that the phosphorylation of CDK1 at Thr14 and Tyr15 and is responsible for the maintenance of the inactive form of MPF. In humans, impaired phosphorylation of Wee1b ( Wee2 ) caused by homozygous mutation of Wee1b is also found to be responsible for the occurrence of fertilization failure.…”

Section: Non‐histone Protein Post‐translational Modifications In Mztmentioning

confidence: 99%

Epigenetic reprogramming during the maternal‐to‐zygotic transition

Chen

Wang

Guo

et al. 2023

MedComm

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After fertilization, sperm and oocyte fused and gave rise to a zygote which is the beginning of a new life. Then the embryonic development is monitored and regulated precisely from the transition of oocyte to the embryo at the early stage of embryogenesis, and this process is termed maternal‐to‐zygotic transition (MZT). MZT involves two major events that are maternal components degradation and zygotic genome activation. The epigenetic reprogramming plays crucial roles in regulating the process of MZT and supervising the normal development of early development of embryos. In recent years, benefited from the rapid development of low‐input epigenome profiling technologies, new epigenetic modifications are found to be reprogrammed dramatically and may play different roles during MZT whose dysregulation will cause an abnormal development of embryos even abortion at various stages. In this review, we summarized and discussed the important novel findings on epigenetic reprogramming and the underlying molecular mechanisms regulating MZT in mammalian embryos. Our work provided comprehensive and detailed references for the in deep understanding of epigenetic regulatory network in this key biological process and also shed light on the critical roles for epigenetic reprogramming on embryonic failure during artificial reproductive technology and nature fertilization.

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Adverse effects of 2-Methoxyestradiol on mouse oocytes during reproductive aging

Jiang

Wang

et al. 2023

Chemico-Biological Interactions

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Meiotic Instability Generates a Pathological Condition in Mammalian Ovum

Cited by 6 publications

References 73 publications

Follicular oocyte as a potential target for severe acute respiratory syndrome coronavirus 2 infection

Follicular oocyte as a potential target for severe acute respiratory syndrome coronavirus 2 infection

Epigenetic reprogramming during the maternal‐to‐zygotic transition

Adverse effects of 2-Methoxyestradiol on mouse oocytes during reproductive aging

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