Meibomian gland dysfunction and dry eye in keratoconus

Pinto, Roberto Damian Pacheco; Abe, Ricardo Y.; Gomes, Flávia Cid; Martini, Alexandre; Barbosa, Eduardo Buzolin; Alves, Mônica

doi:10.5935/0004-2749.20220056

Cited by 3 publications

(2 citation statements)

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“…pilot study of the concentrations of Ap4A in human tears, which increase concomitantly with dry eye and are an objective marker for DES, showed that levels were 20 times higher in KC patients than those of healthy subjects [17]. As a result, a few investigations have proposed that keratoconus might share a similar mechanism with DES, both of which have a negative impact on the meibomian gland [24]. Besides this, DES is more common in KC patients than in healthy controls [16,17].…”

Section: Discussionmentioning

confidence: 99%

Decrease in Tear Film Lipid Layer Thickness in Patients with Keratoconus

Zhou

Feng

2022

JCM

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Keratoconus (KC) is a progressive corneal disorder characterized by thinning and protrusion, mostly of the inferotemporal and central corneal regions. Dysfunction of the meibomian gland, the excretions of which form the lipid layer of the tear film, has been reported to be associated with KC. Thus, this manuscript investigates the correlation among lipid layer thickness (LLT), partial blink rate (PBR), and KC of different degrees. This retrospective study included 54 patients and 24 healthy controls. The anterior corneal curvature, LLT, and PBR were taken from the unilateral eye of all 78 participants. The difference in those ocular parameters between the moderate and severe groups and the control group is significant. No significant association was found between anterior corneal curvature and LLT (r = −0.2, p = 0.15) across all the patients. However, there was a significant negative correlation between anterior corneal curvature and LLT in moderate (r = −0.6, p < 0.05) and severe (r = −0.7, p < 0.05) keratoconus cases. The results also show a significant negative correlation between anterior corneal curvature and PBR (r = −0.41, p < 0.05). Therefore, we conclude that the severity of keratoconus is associated with the thinning of LLT and the reduction of PBR. This may relate to a further epithelial abnormality with the reduced protection of tear film from the air, leading to the release of proteolytic enzymes that degrade stromal collagen and weaken the cornea.

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Section: Discussionmentioning

confidence: 99%

Decrease in Tear Film Lipid Layer Thickness in Patients with Keratoconus

Zhou

Feng

2022

JCM

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“…This inflammatory cycle ultimately leads to disruption of ocular surface homeostasis. [26] In addition, constant stress on the meibomian gland tissue caused by eye rubbing can distort the meibomian gland, which may result in dysfunction of the meibomian gland and dry eye. [27,28]…”

Section: Effect Of Allergic Conjunctivitis and Their Treatment Measur...mentioning

confidence: 99%

Effects of common eye diseases in children and their treatment measures on ocular surface homeostasis: A review

Lv,

Tao,

et al. 2024

Medicine

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Ocular surface homeostasis plays a vital role in maintaining of eye health. Dry eye disease is one of the prominent and typical manifestations of disruption of ocular surface homeostasis that leads to the worsening of ocular surface homeostasis that leads to the worsening of ocular surface disease when it interacts with other pathogenic factors. However, disruption in ocular surface homeostasis in children is often overlooked because of the current methods of assessing ocular surface homeostasis. This review summarizes the main factors affecting ocular surface homeostasis in children, with the aim of drawing the attention of clinicians to the disruption of ocular surface homeostasis in children when dealing with such diseases. Ocular surface homeostasis involves several interrelated components, each of which plays a nonnegligible role in ocular surface homeostasis. Unlike adults, children have a stronger lacrimal gland secretion capacity and milder symptoms when there is a slight disruption of the ocular surface homeostasis. In addition, children’s expressive abilities were weaker. Therefore, dry eye in children is often ignored by doctors and parents, and clinicians should pay more attention to the protection of ocular surface homeostasis when treating children with these diseases. Therefore, there is a need for diagnostic criteria for dry eye disease specific to children.

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Changes in the precorneal tear film at various stages of keratoconus

Averich,

Bubnova

2024

Rus. Ann. Ophthal.

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Meibomian gland dysfunction and dry eye in keratoconus

Cited by 3 publications

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Decrease in Tear Film Lipid Layer Thickness in Patients with Keratoconus

Decrease in Tear Film Lipid Layer Thickness in Patients with Keratoconus

Effects of common eye diseases in children and their treatment measures on ocular surface homeostasis: A review

Changes in the precorneal tear film at various stages of keratoconus

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