Megaloblastic Anaemia of Infancy in Jamaica

MacIver, J. E.; Back, E. H.

doi:10.1136/adc.35.180.134

Cited by 30 publications

(5 citation statements)

References 22 publications

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“…The mild normocytic type observed has been interpreted as being mainly the result of hemodilution Meteoff et al, 1957). A megaloblastosis, attributable to folie acid deficiency, has been observed in a certain proportion of cases (Walt, 1959;Lien-Keng and Ooang, 1959;Maclver and Back, 1960;Adams and Scragg, 1962). A megaloblastosis, attributable to folie acid deficiency, has been observed in a certain proportion of cases (Walt, 1959;Lien-Keng and Ooang, 1959;Maclver and Back, 1960;Adams and Scragg, 1962).…”

Section: Hematological Alterationsmentioning

confidence: 99%

Clinical Aspects of Protein Malnutrition

Viteri

Behar

Arroyave

et al. 1964

Mammalian Protein Metabolism

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Section: Hematological Alterationsmentioning

confidence: 99%

Clinical Aspects of Protein Malnutrition

Viteri

Behar

Arroyave

et al. 1964

Mammalian Protein Metabolism

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“…MacIver and Back (1960), in a review of 50 cases of megaloblastic anaemia of infancy in Jamaica, point out that scurvy is rare there, so that it seemed to these authors unlikely that vitamin C deficiency was an aetiological factor in their cases; they describe, however, one child who had a good reticulocyte response to folic acid but who relapsed on this treatment and developed clinical signs of scurvy. Administration of ascorbic acid (folic acid being continued) led to a second reticulocytosis of 20 per cent and a rapid rise in haemoglobin level.…”

Section: Discussionmentioning

confidence: 99%

Scurvy, Megaloblastic Anaemia and Osteoporosis

Hyams

Ross

1963

Int J Clinical Practice

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Clinical scurvy in the adult is uncommon in this country so that the opportunities for observing its complications are infrequent. One of these, megaloblastic anaemia, is well recognized, but osteoporosis of a degree sufficient to produce crush fractures of vertebrae is rare. This paper records observations on a patient with scurvy complicated by megaloblastic anaemia and osteoporosis who was treated with vitamin C as the sole medication. Case HistoryMrs. D. K., a housewife aged 54, was admitted to University College Hospital (St. Pancras Hospital) on 30th June, 1959. She had been well until a year before admission. Low back pain then developed and later she experienced cramps in the calves and difficulty in walking. Her ankles then became swollen. Extensive ecchymoses appeared on the lower limbs two weeks before admission. The patient thought that she had lost. 3. 4 inches in height in the past year, during which she had attended another hospital for low back pain. She had been provided with a plaster cast, and later a spinal brace, but these appliances had made her back stiffer and she had refused further treatment. She had also consulted an osteopath.The day before admission to hospital she had developed very se\'ere lumbar pain, • like a knife in my back'; her husband volunteered the information that the pain had been so severe that she had threatened to put her head in a gas oven.The patient was menopausal, menstruation having ceased at the age of 50. In her past history she had diphtheria at the age of 18, but nothing else of note apart from the exanthemata of childhood.The patient's husband's place of work was 40 miles away from home. He left at a very early hour in the morning and returned home late at night. The patient felt lonely and neglected and did not trouble to prepare cooked meals for herself. A dietary history showed that the patient's diet had been very deficient of vitamin C for about 3 years, although her intake of calcium and vitamin D had been reasonable (Table I). She had lived almost entirely on sandwiches. Vege• * Now senior medical registrar, _.,,_ddenbrookl''s Hospital, Cambridge TABLE I Calculate,d daily die1ary inlake ot patient Calories 1540 Carbohydrate (g.) 212 Fat (g.) 59 Protein (g.) 40 Calcium (mg.) 566 Iron (mg.) 8. Vilamin C (mg.) 3 Vitamin D (1.U.) 151The fundamental treatment for hay fever, asthma and other allergies is

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“…for 6 3% of similar admissions to the University College Hospital, Jamaica, in 1957 (Maclver and Back, 1960). Although folic acid deficiency is regarded as the aetiology, prolonged infection is an important factor in conditioning the deficiency at this age.…”

Section: 4% Of All Paediatric Admissions In One Year Inmentioning

confidence: 99%

“…These changes are well recognized in Addisonian pernicious anaemia. It is our impression, however, that they are more marked in folic acid deficiency than in vitamin B12 deficiency states, and it is significant that Maclver and Back (1960) found unmistakable changes in the white cells in the marrow in the absence of typical megaloblasts in cases which responded to folic acid.…”

mentioning

confidence: 93%