Meeting the WHO 90% target: antiretroviral treatment efficacy in Poland is associated with baseline clinical patient characteristics

Parczewski, Miłosz; Siwak, Ewa; Leszczyszyn-Pynka, Magdalena; Cielniak, Iwona; Burkacka, E; Pulik, Piotr; Witor, Adam; Müller, Karolina; Zasik, Ewelina; Grzeszczuk, Anna; Jankowska, Maria A.; Lemańska, Małgorzata; Olczak, Anita; Grąbczewska, Edyta; Szymczak, Aleksandra; Gąsiorowski, Jacek; Szetela, Bartosz; Bociąga‐Jasik, Monika; Skwara, Paweĺ; Witak-Jȩdra, Magdalena; Jabłonowska, Elżbieta; Wójcik-Cichy, Kamila; Kamerys, Juliusz; Janczarek, Małgorzata; Krankowska, Dagny; Mikuła, Tomasz; Kozieł, Katarzyna; Bielec, Dariusz; Stempkowska, Justyna; Kocbach, Aleksandra; Błudzin, Wiesława; Horban, Andrzéj

doi:10.7448/ias.20.1.21847

Cited by 14 publications

(13 citation statements)

References 45 publications

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“…This aspect was not analysed in our study, but Wójcik et al [9] showed that patients with better compliance had better virological effect. The cross-sectional study of 5152 Polish HIV-infected patients (56.9% of the country-wide treated patients on ART) demonstrated that the antiretroviral treatment success defined as 'undetectable HIV (viral load < 50 copies/ml)' was achieved in over 90% of the subjects [15]. These findings may confirm the very high compliance rate (median 100%) declared by the patients in our study.…”

Section: Discussionsupporting

confidence: 84%

Treatment compliance and therapy satisfaction in HIV-infected patients

Siwak¹,

Lemańska²,

Firląg-Burkacka³

et al. 2018

HIV & AIDS Review

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Section: Discussionsupporting

confidence: 84%

Treatment compliance and therapy satisfaction in HIV-infected patients

Siwak¹,

Lemańska²,

Firląg-Burkacka³

et al. 2018

HIV & AIDS Review

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“…On the other hand, it was confirmed by Prof. Parczewski and co-authors in observational study, that the proportion of treated patients who achieve HIV RNA suppression in Poland is over 90% (13). Outcome from this study are very promising for the Polish population.…”

Section: Time Lapse Between Detection Of Hiv Infection and Aids Diagnmentioning

confidence: 59%

“…Pomimo to, jak potwierdzają także wyniki badań projektu TAK, znaczny odsetek osób z rozpoznanym zakażeniem HIV nie jest objętych opieką specjalistyczną po rozpoznaniu zakażenia -37,9% (88/232) (11,12). Natomiast jak wskazują wieloośrodkowe badania prof. Parczewskiego i wsp., odsetek pacjentów leczonych, którzy osiągają supresję HIV RNA wynosi ponad 90% (13). Wyniki tych badań dla populacji Polski są więc bardzo obiecujące, dlatego niski poziom objęcia leczeniem osób zakażonych przekłada się na zwiększone ryzyko wystąpienia AIDS w tej grupie oraz kontynuację ryzyka dalszej transmisji wirusa (14).…”

Section: Time Lapse Between Detection Of Hiv Infection and Aids Diagnunclassified

HIV and AIDS in Poland in 2017

Szmulik¹,

Niedźwiedzka-Stadnik²,

Rosińska³

2019

Przegl Epidemiol

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AIM. The aim of the study was to assess the epidemiological situation of newly diagnosed HIV infections and AIDS cases and death among AIDS cases in Poland in 2017 in comparison to the changes in preceding years. MATERIALS AND METHODS. Analysis of the epidemiological situation was based on reports of newly detected HIV cases and AIDS cases and the results of the annual survey of HIV testing conducted among the laboratories throughout the country. RESULTS. In 2017 there were 1,419 HIV cases newly diagnosed in Poland (diagnosis rate: 3.69 per 100,000), including 51 among non-Polish citizens. The frequency of newly detected HIV infections increased by nearly 8% compared to the previous year and by almost 28% compared to the median in 2011-2015 years. The total number of AIDS cases was 108 (incidence 0.28 per 100,000), and 20 people died from AIDS disease (0.05 per 100,000). New HIV diagnoses were reported mainly among people in age 20 to 39 years (69.5%) and among men (88.5%). Among cases with known transmission route, 69.5% concerned among men who had sexual contact with men (MSM). The percentage of MSM cases, similarly to heterosexual cases decrease in comparison to previous year, relatively by 5.7% and 6.4%. The percentage of AIDS cases diagnosed at the same time with HIV diagnosis increased by 6% percentage points in comparison with 2016 year (from 68% to 74% AIDS cases). CONCLUSION. The most HIV cases are diagnosed among MSM, so prophylactic activities are still needed in this key population. It is also need to increase the number of new cases linkage-to-care and to improve the low frequency in HIV testing rate in all population.

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“…However, in the last decade, the predominant transmission route has shifted to sexual transmission, and the rate of HIV diagnosis is increasing among men who have sex with men (MSM) . Currently available combination antiretroviral therapy (cART), accessible via the framework of the Polish National HIV treatment programme, has resulted in notable national treatment success rates, with > 90% of patients treated achieving undetectable HIV viral loads . This has been associated with improved prognosis and a decrease in mortality among HIV‐infected patients.…”

Section: Introductionmentioning

confidence: 99%

Long‐term trends in HIV care entry: over 15 years of clinical experience from Poland

et al. 2019

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Introduction Delay in HIV diagnosis and consequently late care entry with low CD4 counts remain a major challenge for the control of the HIV/AIDS epidemic. The aim of this study was to analyse the evolution of characteristics of the HIV epidemic in Poland. Methods Cross‐sectional data were collected for 3972 HIV‐infected patients followed up in 14 of 17 Polish HIV treatment centres in the years 2000–2015. Clinical data were analysed and factors associated with late presentation (baseline CD4 count < 350 cells/μL or history of AIDS‐defining illness) and advanced HIV disease (baseline CD4 count < 200 cells/μL or history of AIDS) were identified. Results The majority (57.6%) of patients entered care late, while 35.6% presented with advanced HIV disease. The odds of being linked to care late or with advanced HIV disease increased consistently across age categories, increasing from 2.55 [95% confidence interval (CI) 1.46–4.47] for late presentation and 3.13 (95% CI 1.49–6.58) for advanced disease for the 21–30‐year‐old category to 5.2 (95% CI 1.94–14.04) and 8.15 (95% CI 2.88–23.01), respectively, for individuals > 60 years of age. Increased risks of late entry and advanced HIV disease were also observed for injecting drug users [adjusted odds ratio (aOR) 1.74 (95% CI 1.16–2.60) and 1.55 (95% CI 1.05–2.30), respectively], with lower aOR associated with the men who have sex with men transmission route [aOR 0.3 (95% CI 0.31–0.59) and 0.39 (95% CI 0.29–0.53), respectively]. The frequencies of cases in which patients were linked to care late and with advanced HIV disease decreased over time from 67.6% (2000) to 53.5% (2015) (P < 0.0001) and from 43.5% (2000) to 28.4% (2015) (P = 0.001), respectively. Conclusions Despite improvements over time, most patients diagnosed with HIV infection entered care late, with a third presenting with advanced HIV disease. Late care entry remains common among people who inject drugs and heterosexual groups.

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Meeting the WHO 90% target: antiretroviral treatment efficacy in Poland is associated with baseline clinical patient characteristics

Cited by 14 publications

References 45 publications

Treatment compliance and therapy satisfaction in HIV-infected patients

Treatment compliance and therapy satisfaction in HIV-infected patients

HIV and AIDS in Poland in 2017

Long‐term trends in HIV care entry: over 15 years of clinical experience from Poland

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