Meeting report: Regulatory myeloid cells

LaFace, Drake; Talmadge, James E.

doi:10.1016/j.intimp.2011.01.031

Cited by 7 publications

(4 citation statements)

References 10 publications

(10 reference statements)

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“…Unlike MDSCs, these immature myeloid cells are less suppressive (5). MDSCs quickly proliferate and migrate from the bone marrow in response to soluble mediators such as cytokines and chemokines that are produced at sites of inflammation and in the tumor milieu (6). …”

Section: Introductionmentioning

confidence: 99%

“…Granulocytic MDSCs (G-MDSCs) are polymorphonuclear and express high levels of Ly6G and low levels of Ly6C (6–8). G-MDSCs often utilize reactive oxygen species (ROS) and arginase 1 for their immunosuppressive function, and require antigen-specific interactions with their target T cells, although there is system-to-system variability (8–10).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Myeloid-derived suppressor cells in murine AIDS inhibit B-cell responses in part via soluble mediators including reactive oxygen and nitrogen species, and TGF-β

Rastad

Green

2016

Virology

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Monocytic myeloid-derived suppressor cells (M-MDSCs) were increased during LP-BM5 retroviral infection, and were capable of suppressing not only T-cell, but also B-cell responses. In addition to previously demonstrating iNOS- and VISTA-dependent M-MDSC mechanisms, in this paper, we detail how M-MDSCs utilized soluble mediators, including the reactive oxygen and nitrogen species superoxide, peroxynitrite, and nitric oxide, and TGF-β, to suppress B cells in a predominantly contact-independent manner. Suppression was independent of cysteine-depletion and hydrogen peroxide production. When two major mechanisms of suppression (iNOS and VISTA) were eliminated in double knockout mice, M-MDSCs from LP-BM5-infected mice were able to compensate using other, soluble mechanisms in order to maintain suppression of B cells. The IL-10 producing regulatory B-cell compartment was among the targets of M-MDSC-mediated suppression.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Myeloid-derived suppressor cells in murine AIDS inhibit B-cell responses in part via soluble mediators including reactive oxygen and nitrogen species, and TGF-β

Rastad

Green

2016

Virology

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“…Another immune regulatory cell type that has been well studied over the last decade is the myeloid-derived suppressor cell (MDSC) (reviewed in references [29][30][31][32]. Like CD4 ϩ FoxP3 ϩ Treg cells, MDSCs are viewed as primarily acting in a negative fashion with respect to protective T-cell immune responses, particularly in various tumor microenvironments.…”

mentioning

confidence: 99%

Myeloid-Derived Suppressor Cells in Murine Retrovirus-Induced AIDS Inhibit T- and B-Cell ResponsesIn VitroThat Are Used To Define the Immunodeficiency

Green

Cook

Green

2013

J Virol

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“…Recent studies report that MDSCs are involved in producing an immune regulatory cytokine environment that can present antigens to drive immature T cells to become noneffective in tumor clearance. 69,70 Thus, this study aimed to better elucidate the role of the pTyr vaccine in obstructing the tumor-promoting functions of MDSCs. The decrease in the MDSC population observed in tumors from pTyr-vaccinated mice, coupled with the observed decrease of IL-10, MCP-1, arginase II and CXCL5 ( Figure 5) in the tumor microenvironment, supports the hypothesis that the novel and enhanced pTyr vaccine is able to induce armed anti-Tyr effector CD8 + T cells to eliminate MDSCs.…”

Section: Discussionmentioning

confidence: 99%

Novel and enhanced anti-melanoma DNA vaccine targeting the tyrosinase protein inhibits myeloid-derived suppressor cells and tumor growth in a syngeneic prophylactic and therapeutic murine model

et al. 2014

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Melanoma is the most deadly type of skin cancer, constituting annually ∼ 75% of all cutaneous cancer-related deaths due to metastatic spread. Currently, because of metastatic spread, there are no effective treatment options for late-stage metastatic melanoma patients. Studies over the past two decades have provided insight into several complex molecular mechanisms as to how these malignancies evade immunological control, indicating the importance of immune escape or suppression for tumor survival. Thus, it is essential to develop innovative cancer strategies and address immune obstacles with the goal of generating more effective immunotherapies. One important area of study is to further elucidate the role and significance of myeloid-derived suppressor cells (MDSCs) in the maintenance of the tumor microenvironment. These cells possess a remarkable ability to suppress immune responses and, as such, facilitate tumor growth. Thus, MDSCs represent an important new target for preventing tumor progression and escape from immune control. In this study, we investigated the role of MDSCs in immune suppression of T cells in an antigen-specific B16 melanoma murine system utilizing a novel synthetic tyrosinase (Tyr) DNA vaccine therapy in both prophylactic and therapeutic models. This Tyr vaccine induced a robust and broad immune response, including directing CD8 T-cell infiltration into tumor sites. The vaccine also reduced the number of MDSCs in the tumor microenvironment through the downregulation of monocyte chemoattractant protein 1, interleukin-10, CXCL5 and arginase II, factors important for MDSC expansion. This novel synthetic DNA vaccine significantly reduced the melanoma tumor burden and increased survival in vivo, due likely, in part, to the facilitation of a change in the tumor microenvironment through MDSC suppression.

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Meeting report: Regulatory myeloid cells

Cited by 7 publications

References 10 publications

Myeloid-derived suppressor cells in murine AIDS inhibit B-cell responses in part via soluble mediators including reactive oxygen and nitrogen species, and TGF-β

Myeloid-derived suppressor cells in murine AIDS inhibit B-cell responses in part via soluble mediators including reactive oxygen and nitrogen species, and TGF-β

Myeloid-Derived Suppressor Cells in Murine Retrovirus-Induced AIDS Inhibit T- and B-Cell ResponsesIn VitroThat Are Used To Define the Immunodeficiency

Novel and enhanced anti-melanoma DNA vaccine targeting the tyrosinase protein inhibits myeloid-derived suppressor cells and tumor growth in a syngeneic prophylactic and therapeutic murine model

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