Mediterranean Diet Supplemented With Coenzyme Q10 Modifies the Expression of Proinflammatory and Endoplasmic Reticulum Stress–Related Genes in Elderly Men and Women

Abstract

We have investigated whether the quality of dietary fat and supplementation with coenzyme Q(10) (CoQ) modifies expression of genes related with inflammatory response and endoplasmic reticulum stress in elderly persons. Twenty participants received three diets for 4 weeks each: Mediterranean diet + CoQ (Med + CoQ), Mediterranean diet (Med), and saturated fatty acid-rich diet (SFA). After 12-hour fast, volunteers consumed a breakfast with a fat composition similar to that consumed in each of the diets. Med and Med + CoQ diets produced a lower fasting calreticulin, IL-1b, and JNK-1 gene expression; a lower postprandial p65, IKK-b, MMP-9, IL-1b, JNK-1, sXBP-1, and BiP/Grp78 gene expression; and a higher postprandial IkB-a gene expression compared with the SFA diet. Med + CoQ diet produced a lower postprandial decrease p65 and IKK-b gene expression compared with the other diets. Our results support the anti-inflammatory effect of Med diet and that exogenous CoQ supplementation in synergy with a Med diet modulates the inflammatory response and endoplasmic reticulum stress.

RETRACTED ARTICLE: The effects of coenzyme Q10 supplementation on gene expression related to insulin, lipid and inflammation in patients with polycystic ovary syndrome

“…In addition, in another study was seen that CoQ10 administration at a dosage of 20 mg/kg increased insulin sensitivity and had antidiabetic properties via increasing activity of phosphatidylinositol kinase (PI3K) in rats fed a high-fat, high-fructose diet [7]. Mediterranean diet with CoQ10 also modified gene expression of pro-inflammatory markers among elderly men and women for four weeks [8].…”

What Is the Molecular Signature of Mind–Body Interventions? A Systematic Review of Gene Expression Changes Induced by Meditation and Related Practices

“…Similarly, a diet rich in vegetables, fruits, fish, and unsaturated fats is associated with anti-inflammatory gene profile, while the opposite has been found for Western diet consisting of saturated fats, sugars, and refined food products (58). Similar changes have been observed in older adults after just one Mediterranean diet meal (59) or in healthy adults after consuming 250 ml of red wine (60) or 50 ml of olive oil (61). However, in spite of this literature, only two of the studies we reviewed tested if the MBIs had any influence on lifestyle (e.g., sleep, diet, and exercise) that may have explained gene expression changes.…”

Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: a double blind, placebo, controlled randomized clinical trial

“…In a similar study, consumption of Mediterranean diet supplemented with CoQ10 for 4 weeks in elderly subjects produced a lower postprandial MMP-9 and IL-1β gene expression, compared with control diets. 41 Inui et al showed that UVBinduced MMP-1 production of normal keratinocyte decreased in the presence of CoQ10. 33 In another study, Bahar et al reported that incubation of CoQ10 reduced MMP-2 activity in MCF-7 cell line as a breast cancer cellular model at a dose proportionate manner.…”