Medicinal plants used for the treatment of mucositis induced by oncotherapy: a systematic review

Eubank, Patrícia Leão Castillo; Abreu, Lucas Guimarães; Violante, Ivana Povoa; Volpato, Luiz Evaristo Ricci

doi:10.1007/s00520-021-06247-0

Cited by 17 publications

(6 citation statements)

References 59 publications

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“…Chamomile had the ability to reduce severity and lesion incidence and improved pain symptomatology. 7 Furthermore, the results of a systematic review by Silva et al demonstrated that different forms of chamomile was effective in the treatment of oral mucositis in cancer patients due to its anti-inflammatory action. 55 Another problem experienced by cancer patients is anxiety and depression related to the disease and the treatment process.…”

Section: Discussionmentioning

confidence: 99%

“… 5 Although these treatments aim at improving the quality of life of cancer patients, they are associated with many side effects leading to acute symptoms such as mucositis, dermatitis, stomatitis, nausea, vomiting, xerostomia, and skin scaling. 6 , 7 It has been estimated that about 40% of patients are treated with standard chemotherapy develop mucositis. 8 Nausea and vomiting due to chemotherapy are among the most severe side effects of the treatment and of the major concerns of patients with cancer, with a prevalence of 54% to 96%.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Chamomile on the Complications of Cancer: A Systematic Review

et al. 2023

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Background and objectives: Despite significant advances in the diagnosis and treatment of cancer, many people across the world still suffer from this chronic disease and its complications. Chamomile as an herbal medicine has gained an increasing attention for relieving cancer complications. This study aimed to integrate and synthesize current international evidence regarding the effect of chamomile on cancer complications. Methods: A systematic review was undertaken. Five online databases including Web of Science, PubMed [including MEDLINE], Cochrane Library, Scopus, and Embase were searched and articles published from inception to January 2023 were retrieved. All clinical trials and similar interventional studies on human subjects examining the effects of chamomile on cancer complications were included in the review and research synthesis. Relevant data were extracted from eligible studies after quality appraisals using proper methodological tools. The review results were presented narratively given that meta-analysis was impossible. Results: A total of 2240 studies were retrieved during the search process, but 18 articles were selected. The total sample size was 1099 patients with cancer of which 622 participants were female. Fifteen studies used an RCT design. Various forms of chamomile were used such as mouthwash, topical material, tea, capsule, syrup and aromatherapy massage. Chamomile effectively reduced oral mucositis, skin complications, depression, and vomiting and also improved appetite and quality of life among cancer patients. Conclusion: The use of chamomile as a non-pharmacologic and safe method can be helpful for mitigating cancer complications in patients with cancer. Therefore, it can be incorporated into routine care along with other therapeutic measures to reduce patients’ suffering related to cancer. Systematic review registration number (PROSPERO): CRD42022307887

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Chamomile on the Complications of Cancer: A Systematic Review

et al. 2023

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“…The majority of them are easily implementable and low‐cost (Ferreira et al., 2022; Yarom et al., 2020). In addition, nonpharmacological interventions have fewer side effects and have been demonstrated to alleviate oral mucositis effectively (Eubank et al., 2021; Ferreira et al., 2022; Yarom et al., 2020). For example, natural plants, honey, nutritional supplements and probiotics possess various ameliorative properties for oral mucositis, including anti‐inflammatory, antibacterial, antioxidant and immunomodulatory effects and cell proliferation promotion (Liu et al., 2022; Lozano et al., 2021; Yarom et al., 2020); low‐level laser therapy could promote the repair of oral mucosal tissue and reduce the inflammatory response through photon‐generated biochemical reactions (Lai et al., 2021); while health education enhances the awareness and ability of patients to treat oral mucositis, and oral cleaning and wetting agents can decrease the amount of oral bacteria and maintain oral hygiene (Elad et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of nonpharmacological interventions for severe radiation‐induced oral mucositis among head and neck cancer patients: A network meta‐analysis of randomised controlled trials

Zhang,

Li,

Zhang

et al. 2024

Journal of Clinical Nursing

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Aims and ObjectivesTo assess the effectiveness of different nonpharmacological treatments for severe radiation‐induced oral mucositis in patients with head and neck cancer.BackgroundRadiation‐induced oral mucositis is highly prevalent in patients with head and neck cancer. Current medications for radiation‐induced oral mucositis are limited in effectiveness and susceptible to side effects, and while there is an increasing adoption of nonpharmacological interventions, the optimal one remains unclear.DesignSystematic review and network meta‐analysis based on the PRISMA‐NMA guidelines.MethodsSix databases were searched. Two authors independently performed the literature screening, data extraction and methodological quality assessment of the included studies. Traditional pairwise meta‐analysis was performed by R Studio. A network meta‐analysis was then conducted to assess the effects of nonpharmacological interventions for severe radiation‐induced oral mucositis in patients with head and neck cancer.ResultsFifty‐two studies involving seven types of nonpharmacological interventions were enrolled. The network meta‐analysis indicated that natural plant‐based therapies might be the most effective, health education interventions might be the second most effective, and honey might be the third most effective interventions for reducing the incidence of severe radiation‐induced oral mucositis. For reducing the incidence of severe oral mucositis‐related pain, the pairwise meta‐analysis showed that only natural plant‐based therapies and health education interventions were effective.ConclusionsNonpharmacological interventions are effective in the management of severe radiation‐induced oral mucositis among patients with head and neck cancer.Relevance to clinical practiceNonpharmacological interventions are a category of safe and effective adjunctive therapies that should be encouraged in clinical practice.Trial registration detailsCRD42023400745.

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“…Many strategies, such as oral hygiene, sodium bicarbonate, benzydamine hydrochloride rinses, glutamine, growth factor, cytokines, anti-inflammatory drugs, analgesics, low-level laser therapy, and cryotherapy [ 4 , 7 ] have been suggested for treating oral mucositis, but none of these strategies are fully effective; moreover, some agents are associated with drug side effects and ancillary costs [ 8 , 9 ]. In addition to being less expensive, more widely available [ 10 ], and having fewer side effects [ 11 ] than synthetic drugs, natural products also show potential in pharmacological laboratory studies and clinical trials for their antioxidant, anti-inflammatory, antimicrobial, immunomodulatory, and wound-healing properties [ 12 ], all of which may have varying degrees of impact on the pathophysiology of mucositis.…”

Section: Introductionmentioning

confidence: 99%

Clinical efficacy and applicability of natural products in the treatment and prevention of radiotherapy-induced oral mucositis: A systematic review

Zhang,

Fan,

Xie

et al. 2024

PLoS ONE

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The aim of this systematic review was to describe the efficacy and acceptability of natural products in the management of oral mucositis caused by radiation. From the day it started to August 7, 2023, a thorough search for randomized controlled trials (RCTs) was carried out among seven databases: the Web of Science, PubMed, Embase, OVID, Scopus, the Cochrane Library and the CINAHL database. Only English-language articles were identified during the search. Using the revised Cochrane risk-of-bias tool, version 2, two researchers screened the articles, collected information on study characteristics, and appraised risks of bias. The data were analyzed and descriptively presented with a narrative synthesis methodology involving the Synthesis Without Meta-Analysis (SWiM) reporting element applied in detail. The PROSPERO registration number of this study is CRD42023476932. Thirty-six clinical trials were included in the study; the included studies included a variety of 20 types of natural products. Honey and Curcuma longa were the most commonly assessed natural products. A total of 2,400 participants reported taking part in therapy with natural products for oral mucositis. Natural products demonstrated substantial efficacy in terms of influencing intensity, incidence, pain score, quality of life, and symptoms such as xerostomia and dysphagia. Except for manuka honey, most natural products were well accepted. Regarding the clinical trials’ risk of bias, 2 clinical trials (5.56%) had a high risk of bias, 17 studies (47.2%) had a low risk of bias, and 17 studies (47.2%) were rated with “some concern.” Natural remedies work well as alternate treatments for managing oral mucositis caused by radiation therapy. However, additional clinical trials are still needed. The safety of these conventional medications as well as their effectiveness and safety when used in combination with other conventional or naturopathic therapies should be fully examined.

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Medicinal plants used for the treatment of mucositis induced by oncotherapy: a systematic review

Cited by 17 publications

References 59 publications

Effect of Chamomile on the Complications of Cancer: A Systematic Review

Effect of Chamomile on the Complications of Cancer: A Systematic Review

Efficacy of nonpharmacological interventions for severe radiation‐induced oral mucositis among head and neck cancer patients: A network meta‐analysis of randomised controlled trials

Clinical efficacy and applicability of natural products in the treatment and prevention of radiotherapy-induced oral mucositis: A systematic review

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