Medicinal Plant Using Ground State Stabilization of Natural Antioxidant Curcumin by Keto-Enol Tautomerisation

Abstract

Curcumin is a medicinal agent that exhibits anti-cancer properties and bioactive pigment in Turmeric has a huge therapeutic value. It has a keto-enol moiety that gives rise to many of its chemical properties. A recent study has shown that keto-enol tautomerisation at this moiety is implicated the effect of curcumin. The tautomerisation of curcumin in methanol, acetone and acetonitrile are used in nuclear magnetic resonance (1H, 13C) spectroscopy. It was characterized using UV, IR and Raman spectral values. The molecular electrostatic potential surface of the Curcumin has been visualized in electropositive potential in the region of the CH3+ group and most electronegative potential in the two oxygen atom has very strong binding group. In the following, the modality of structural and thermo dynamical parameters, electrophilicity (ω), chemical potential (μ), chemical hardness (η) and electronic charge transfer confirms the local reactivity. The rate constant of tautomerisation of curcumin shows strong temperature dependence. Molecular electrostatic potential and Temperature dependence of various thermodynamic properties like is increase with increase in temperature for monomer and dimer of various electrical fields.

Photoactive Thin-Film Structures of Curcumin, TiO2 and ZnO

“…In Figure 6 , we have collected representative UV-vis spectra for our thin-film samples from all the aforementioned sample categories. First of all, for the parent Cur, ZnO and TiO 2 films, the absorption maxima (λ max ) are seen—as expected—at 435 nm (due to the π − π* electronic transition of Cur [ 46 , 47 ]), at 360 nm [ 56 ], and at 422 nm, respectively. The slightly different λ max value of 435 nm for our Cur film as compared to the previous data for curcumin solutions (ca.…”

“…The inset in Figure 2 a shows that this dependence of the film thickness on the Cur concentration in the solution is rather linear. The well-controlled S-C-growth of Cur films was further affirmed from the UV-vis absorption spectra ( Figure 2 b), showing the gradual (linear) increase of the absorption peak around 430 nm (originating from the π − π* electronic transition [ 46 , 47 ]) with increasing Cur concentration. From GIXRD (grazing-incidence X-ray diffraction) measurements, the films were found to be amorphous.…”

“…Most importantly, the FTIR (Fourier transform infrared) spectrum shown for a representative sample in Figure 2 c clearly reveals all the characteristic peaks due to the functional groups of curcumin [ 47 , 48 ]: presence of aromatic rings is seen from the peaks at 1589 cm −1 (symmetric aromatic ring stretching) and at 970 cm −1 (trans -C-H vibrations of aromatic ring), β-diketone groups from the peaks at 1510 cm − 1 (C=O stretching) and at 1626 cm −1 (O=C-CH 2 -C=O moiety), methoxy groups (-OCH 3 ) from the peak at 1030 cm −1 (C-O-C stretching vibration), and hydroxyl groups (-OH) from the large valley around 3500 cm −1 . These features are essential for the antiviral functionality of curcumin [ 10 ].…”

Experimental and Theoretical Characterization of Thio coumarin by NLO single crystal in DFT Calculations

“…As seen from Table S6, the standard thermodynamic functions increase with increasing temperature, due to the intensities of molecular vibration increase; it is observed that the entropy increases but the enthalpy and heat capacity remain constant. According to Boyle's law for gases, a molecule is compressed at constant temperature its volume decreases [17][18]. Due to decreasing volume, the number of possible sites that occupied by particles of the molecule may be restricted.…”

Nanoformulations of curcumin and quercetin with silver nanoparticles for inactivation of bacteria

“…As shown in Figures 1a-b, there are two main forms of enol and keto for curcumin. It should be mentioned that the enol form is more energetically stable compared to the keto one (2,3). Moreover, this plant species has numerous chemical compounds including essential oils, alpha and beta turmeric, ginger, glucose, fructose, arabinose, and starch.…”