Medicinal attributes of major phenylpropanoids present in cinnamon

Sharma, Upendra K.; Sharma, Amit Kumar; Pandey, Abhay K.

doi:10.1186/s12906-016-1147-4

Cited by 67 publications

(37 citation statements)

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“…Our observation agrees with the previous results of antitumor activity of the ethanolic extract of B. variegata extract against Dalton's ascetic lymphoma (DAL) in Swiss albino mice [93] and in N-notrosodiethylamine induced experimental liver tumour in rats and human cancer cell lines [94]. Our findings are also in agreement with the previous results of many herbal drugs such as alcoholic extract of Thuja occidentalis [95], aqueousmethanol (3:7) extract of Boerhaavia diffusa [96], methanolic extract of Withania somnifera roots [97], naturally occurring allyl and phenyl isothiocyanates [98], curcumin [99], sulphorafane [100], B. variegata leaf extract [101], Piper longum against A549 cell line [102], Cinnamaldehyde and eugenol [103] etc. have been reported to inhibit metastasis.…”

Section: Discussionsupporting

confidence: 92%

In vivo antitumor potential of extracts from different parts of Bauhinia variegata linn. Against b16f10 melanoma tumour model in c57bl/6 mice

Pandey

2017

Appl Cancer Res

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Background: Melanoma is a metastatic type of skin cancer that is difficult to treat and the majority of efforts are directed to the design of new drugs. Medicinal Plants have been the primary source of medicines since life on earth; more than 50% of existing cancer treatments is derived from plants. Bauhinia variegata is well-known medicinal plant used from the ancient era to till date for their medicinal values. Scientific literatures have not documented any evidence of the antitumour potential of Bauhinia variegata against B16F10 melanoma tumor model in C57BL mice. The present investigation was undertaken to explore the antitumour activity of Leaf, stem bark and flower extract of Bauhinia variegata against B16F10 melanoma tumour model in C57BL mice. Methods: Hydro-methanolic extract prepared from the leaf, stem bark and flower of Bauhinia variegata were assessed for their antitumor activity. The extracts at doses of 500 and 750 mg/kg b.wt. were given orally along with cyclophosphamide (chemotherapeutic drug) for 40 days for exploring antitumor activity against melanoma tumor (B16F10) in C57BL mice. Inhibition of tumor growth, increase in survival time of animal with treatment, histopathological studies and antioxidant parameter were determined. Results: The Present investigation showed significant effect of the B. variegata L. in preventing melanoma tumor by B16F10 cell line in C57BL/6 mice. As compared with the tumour control group, the remarkable results especially in the group which received B. variegata extract and cyclophosphamide together were obtained for all of the measured parameters. Dose dependent response was observed in tumor volume, inhibition rate, life span time and antioxidant parameter of extracts. Combination treatment of cyclophosphamide and B. variegata extracts showed more pronounced effect. Conclusions: These findings suggest that B. variegata hydromethanolic extract may contain bioactive compounds of potential therapeutic significance which are relatively safe from toxic effects, and can compromise the medicinal use of this plant in folk medicine.

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Section: Discussionsupporting

confidence: 92%

In vivo antitumor potential of extracts from different parts of Bauhinia variegata linn. Against b16f10 melanoma tumour model in c57bl/6 mice

Pandey

2017

Appl Cancer Res

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“…Results at Table (3) showed significant improve of feed conversion ratio in basil, fennel, cinnamon, oregano and mixture treatments by 5.6, 5.6, 6.2, 7.7 and 9.2% respectively, compared to the control group. These results may be due to the ability of these herbs on the reactive and bring about oxidation effect of bio-molecules of proteins, lipids and nucleic acids which are associated with many degenerative diseases (Sharma et al, 2016). There were gradually satisfactory while insignificant decreasing in feed intake by (4.2,3.6,3.1,3.0 and 0.8%) for cinnamon, basil, fennel, oregano and mixture treatments, respectively, compared to the control group (Table 3).…”

Section: Broilers Performancementioning

confidence: 99%

“…Cinnamon , Cinnamomum Zeylanicum (Lauraceae) have principle components cinnamaldehyde possessed metal ion chelating lipo-protective, antibacterial and anti-proliferative activities (Erdogru et al, 2003), antiinflammatory (Han and Parker 2017) and have eugenol acting as antioxidant (Pandey et al, T 2012) which acting with cinnamic acid and cineol component to neutralize free radicals to hence they mitigate their harmful effects indicating their usefulness in food and pharmaceutical sector (Sharma et al, 2016) as well as provides protection against allergens causing atherosclerosis (Nayak et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Effect of Some Herbs as Feed Additives on Performance, Digestibility, Carcass Characteristics and Blood Parameters of Broilers

Ibrahim¹,

Fattah²,

Mallah³

et al. 2019

Egyptian Journal of Nutrition and Feeds

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wo hundreds and sixteen one-day-old Coob-500 chicks were fed various diets for 6-weeks period and were equally divided into 6 treatment groups of 36 birds each, (3 replicates per group, of 12 birds each), using a completely randomized design, for 42 days. The diets included a control diet (without any additives) while the other five diets contained sweet basil (Ocimum basilicum L), fennel (Foeniculum vulgare),cinnamon (Cinnamomum Zeylanicum), oregano (Origanum vulgare L.) and there blend at 1% level as feed additives (10 g/kg feed). The results revealed that herb mixture treatment birds significantly increased the live body weight by 9% followed by the oregano treatment by 4.9% then the fennel treatment by 2.8% compared to the control group. However, the dietary herbs significantly improved the feed conversion ratio for Basil and Fennel treatments by the same value 5.6%, Cinnamon by 6.2, Oregano by 7.7 and for mixture treatments by 9.2% compared to the control group. Basil significantly decreased the abdominal fat by 53% and the liver weight by 7% compared to the control group. The mixture and oregano treatments significantly decreased the gizzard weight by 35.3% and 34.2% respectively, compared to the control group. Basil significantly decreased the total blood serum cholesterol by 17.2 % compared to the control group. The fennel and oregano significantly increased the A/G ratio at the same value by 29% compared to the control group. Cinnamon significantly improved the CP digestibility by 3.15 % compared to the control group. It can be concluded that the mixture of basil, fennel, cinnamon and oregano at the level of 1% significantly increased most growth performance parameters followed by oregano, cinnamon, basil and fennel.

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“…Cinnamomum belongs to genera of Lauraceae family that includes many species with different properties and commonly used as spices in food or as fragrances. Furthermore some of these species are used in traditional medicine and, relatively to species parthenoxylon, it has been demonstrated that the extract of the bark has antioxidant effects [49]. Several constituents of cinnamomum species have cytotoxic and apoptotic activities on various cancer cell lines [50].…”

Section: Lignans Isolated From Plantsmentioning

confidence: 99%

Natural Compounds: Molecular Weapons against Leukemia’s

Taverna¹,

Corrado

2017

J Leuk

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Nowadays cancer is one of the main reasons of death all over the world and it is estimated that deaths caused by cancer will grow dramatically in the next decades. Even if chemotherapy is the election therapy for solid tumors, as well as leukemias and lymphomas, cancer treatments are in continuous evolution trying to solve the problem of resistance mainly due to low accumulation of the drug in tumor cells (MDR). Natural compounds represent a valid alternative to treat several disease and recently the scientific community focus on these natural compounds and plant metabolites with therapeutic activities and low toxicities compared with synthetic ones.A combination therapy, that join conventional chemotherapy with natural plant metabolites, is now considered a new promising strategy to overcome MDR and reduce cellular toxicity; in particular, in leukemia due to its very complex origin and development of leukemogenesis.Here, we want to summarize and update the recent applications of natural compounds in the treatment of leukemia.

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Medicinal attributes of major phenylpropanoids present in cinnamon

Cited by 67 publications

References 50 publications

In vivo antitumor potential of extracts from different parts of Bauhinia variegata linn. Against b16f10 melanoma tumour model in c57bl/6 mice

In vivo antitumor potential of extracts from different parts of Bauhinia variegata linn. Against b16f10 melanoma tumour model in c57bl/6 mice

Effect of Some Herbs as Feed Additives on Performance, Digestibility, Carcass Characteristics and Blood Parameters of Broilers

Natural Compounds: Molecular Weapons against Leukemia’s

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