Medication adherence among patients with chronic conditions in Italy

Napolitano, Francesco; Napolitano, Paola; Angelillo, Italo Francesco

doi:10.1093/eurpub/ckv147

Cited by 38 publications

(43 citation statements)

References 31 publications

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“…In accordance with our study, Ma et al and Napolitano et al revealed that higher education is associated with higher adherence (25,26). It is probably due to having more awareness regarding the importance of regular taking of medications and self-care among patients with higher education.…”

Section: Discussionsupporting

confidence: 91%

Treatment Adherence in Patients with Hypertension: A Cross Sectional Study from Southeast of Iran

Sadeghi

Ahmadipour

2018

Shiraz E-Med J

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Background: Poor adherence to antihypertensive treatment has been a global challenge. It is necessary for health care providers to identify the factors affecting treatment adherence. Objectives: The present study aimed to investigate the adherence to treatment and its related factors in patients with hypertension. Methods: A cross sectional study carried out from September 2017 to March 2018 on 600 patients with hypertension who were covered by urban community health centers in Kerman, Iran. The Persian version of Morisky medication adherence scale (P-MMAS-8) and hypertensive treatment adherence scale (HTAS) were used for assessing adherence to the medication and treatment, respectively. Data was analyzed by SPSS software version 19.0 using Independent t-test, ANOVA and logistic regression. Results: The mean age of participants was 56.44 ± 12.3 years, with the majority of them (70.0%) being female. Poor adherence to medication and treatment was found in 304 (50.7%) and in 238 (39.7%) patients, respectively. Age, level of education, and the presence of concurrent medical disease and psychological disorder significantly predicted the adherence to treatment. Conclusions: Poor adherence was common among hypertensive patients in our primary health care setting. Therefore, it is necessary for our health care providers to identify the factors associated with poor adherence to be intervened timely.

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Section: Discussionsupporting

confidence: 91%

Treatment Adherence in Patients with Hypertension: A Cross Sectional Study from Southeast of Iran

Sadeghi

Ahmadipour

2018

Shiraz E-Med J

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“…Our finding that the participants used in average 4.2 regular drugs is in line with other studies reporting on persons with chronic conditions using in average 3-5 regular drugs. [19][20][21] Only a third of the participants in our cohort used oral spasmolytic drugs regularly, even though nearly 80% of them reported at least some level of spasticity. The explanation could be that mild spasticity can have a positive impact on functionality, or the fact that the most common oral spasmolytic drugs come with undesirable side effects as sedation and dizziness.…”

Section: Discussionmentioning

confidence: 84%

Use of medicines, adherence and attitudes to medicines among persons with chronic spinal cord injury

Høgholen

Storhaug²,

Kvernrød³

et al. 2017

Spinal Cord

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The persons with SCI included in this study used in average the same number of regular drugs compared to persons with other chronic conditions. Regardless of high overall adherence, the participants were more concerned about their medicines compared to other patient groups. Further studies are required for understanding adherence and attitudes toward medicines in this population, especially to help the persons with chronic SCI feel safe about their drug regimen.

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“…Poor adherence is associated with a higher residual cardiovascular risk (for the patient) and a high healthcare burden, due to greater effort to improve BP with additional diagnostic tests and interventions, such as renal denervation (RDN) . Previous cross‐sectional studies published information on factors of nonadherence in patients with hypertension . However, almost all studies on adherence in hypertension are based on the self‐assessment Morrisky questionnaire; a method shown to overestimate adherence and to be potentially biased.…”

Section: Introductionmentioning

confidence: 99%

Medication adherence in patients with apparent resistant hypertension: findings from the SYMPATHY trial

Jäger

Maarseveen

Bots

et al. 2017

Brit J Clinical Pharma

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AIMSHypertension is only controlled in approximately 35% of the patients, which could be partially due to nonadherence. Recently, bioanalytical assessment of adherence to blood pressure (BP) lowering drugs has gaining interest. Our aim was to explore possible determinants of nonadherence in treatment resistant hypertension, assessed by objective screening for antihypertensive agents in serum. The secondary aim was to study the effect of adherence on the change in BP. METHODSThis project was a substudy of SYMPATHY; an open-label randomized-controlled trial to assess the effect of renal denervation on BP 6 months after treatment compared to usual care in patients with resistant hypertension. Stored serum samples were screened for antihypertensive agents to assess adherence at baseline and 6 months after intervention, using liquid chromatographytandem mass spectrometry. Office and 24-h BP were measured on the same day as blood was sampled. Patients and physicians were unaware of adherence measurements. RESULTSNinety-eight baseline and 83 6-month samples were available for analysis. Sixty-eight percent [95% confidence interval (CI) 59-78%] of the patients was nonadherent (n = 67). For every onw pill more prescribed, 0.785 [95%CI 0.529-0.891] prescribed pill was less detected in blood. A decrease of one pill in adherence between baseline and 6 months was associated with a significant rise in office systolic BP of 4 (95%CI 0.230-8.932) mmHg. CONCLUSIONObjective measurement of BP lowering drugs in serum, as a tool to assess adherence, showed that nonadherence was very common in patients with apparent resistant hypertension. Furthermore, the assessment results were related to (changes in) blood pressure. Our findings provide direct and objective methodology to help the physician to understand and to improve the condition of apparent resistant hypertension. British Journal of Clinical Pharmacology WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Hypertension is only pharmacologically controlled in 35% of the patients.• Objective screening of BP lowering drugs showed that poor adherence is common among resistant hypertensive patients.• Non-adherence to BP lowering medication might result in unnecessary diagnostic tests and interventions, such as renal denervation, to improve BP. WHAT THIS STUDY ADDS• (Change in) adherence, quantified with a bioanalytical assay using serum, was strongly related to number of prescribed BP lowering drugs and (change in) office blood pressure.• Our findings provide objective methodology to help the physician to understand and to improve the condition of apparent resistant hypertension.

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Medication adherence among patients with chronic conditions in Italy

Abstract: The findings emphasize the need for improving information for the individuals affected by chronic diseases concerning the risks of non-adherence in order to encourage responsible behaviour to prescribed medications.

Cited by 38 publications

References 31 publications

Treatment Adherence in Patients with Hypertension: A Cross Sectional Study from Southeast of Iran

Treatment Adherence in Patients with Hypertension: A Cross Sectional Study from Southeast of Iran

Use of medicines, adherence and attitudes to medicines among persons with chronic spinal cord injury

Medication adherence in patients with apparent resistant hypertension: findings from the SYMPATHY trial

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