Medical phycology 2017

Todd, John R.; Matsumoto, Tadahiko; Ueno, Ryohei; Murugaiyan, Jayaseelan; A, Britten; King, John W.; Odaka, Yoshinobu; Oberle, Arnold; Weise, Christoph; Roesler, Uwe; Pore, R. S.

doi:10.1093/mmy/myx162

Cited by 48 publications

(107 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The traditional attitude to the Prototheca species is that they are of low virulence to human beings who have intact immune systems but are threatening to individuals with immunocompetent or immunosuppressed problems. 5 Our report and some other literature hinted that old patients with diabetes mellitus were a group of vulnerable populations and should raise attention, especially when they have exposure risk to the contaminated region. 10,12 So far, the genus Prototheca is composed of at least eight species, like P wickerhamii, P zopfii, P blaschkeae, P cutis, P miyajii, P stagnora, P ulmea, and P tumulicola, all of which present close relationships in the biological phenotype and the genomic background.…”

Section: Discussionmentioning

confidence: 58%

“…Since Davies first described the infection of Prototheca species in 1964, human protothecosis has spread worldwide, especially in recent years. [4][5][6][7] In our country, cutaneous protothecosis has been reported successively in mainland China, Hong Kong, and Taiwan. 8,9 Until now, at least two protothecosis cases occurred in Shanghai, China.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Multiple cutaneous infections caused by Prototheca wickerhamii

Zhao

Chen

2020

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Human protothecosis is a microalgae infection caused by members of genus Prototheca, which was rare but has become a threat with an increasing tendency, especially in recent years. 1 It was more commonly reported in patients who were under the immunosuppressed condition, and was easily misdiagnosed. 2 Here, we report a case of cutaneous protothecosis in an old patient who had type II diabetes mellitus without clinical signs of the compromised immune system, and share our experiences provided

show abstract

Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Multiple cutaneous infections caused by Prototheca wickerhamii

Zhao

Chen

2020

Clinical Laboratory Analysis

View full text Add to dashboard Cite

show abstract

“…6 Todd et al stated that intravenous AMPH-B was the most effective medication for protothecosis. 7 Only three cases of Prototheca keratitis have been reported. In the first case, a Prototheca infection was detected in a patient after undergone PKP for Fuchs corneal endothelial dystrophy.…”

Section: Discussionmentioning

confidence: 99%

<p>Long Term Follow-Up of <em>Prototheca</em> keratitis: A Case Report</p>

Minato¹,

Yoshikawa²,

Nakanishi³

et al. 2020

IMCRJ

View full text Add to dashboard Cite

Background: Prototheca spp. are rare human pathogens, and only three cases of Prototheca keratitis have been reported. They were treated with anti-fungal drugs and surgical excision. Two of the three cases were successful, and the case of an immunocompromised patient was not successful. Thus, the best treatment of Prototheca keratitis is still undetermined, and further investigations are needed. The purpose of this report is to present our findings in a case of Prototheca keratitis that was successfully treated with topical medications without surgical excision. Methods: This study was performed in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of Hidaka Medical Center, Toyooka Hospital. A written informed consent was obtained from the patient before beginning the medical treatments. Case Report: A 75-year-old man with a history of stage 4 prostate carcinoma and bilateral limbal stem cell deficiency had undergone keratoepithelioplasty on his left eye for the deficiency. Postoperatively, a greyish-white epithelial opacity was noted on the central cornea of his left eye, and he had been treated with topical fluorometholone and oral dexamethasone together with a therapeutic contact lens. Corneal smears and contact lens swabs were positive for Prototheca spp. He required a continuous treatment with amphotericin B (AMPH-B) ointment, topical fluconazole (FLCZ), and voriconazole (VRCZ). This treatment protocol was effective, but recurrences developed when his general condition worsened. Conclusion: Our findings indicate that Prototheca keratitis can be successfully treated but not cured with topical AMPH-B, FLCZ, and VRCZ without surgical treatment. However, recurrences can develop when the general condition of the patient worsens. Thus, continuous monitoring and treatment are necessary in cases of Prototheca keratitis.

show abstract

“…Prototheca wickerhamii represents the predominant etiological agent of human protothecosis, affecting both immunocompetent and immunocompromised patients ( Todd et al., 2018 ). Clinically, the disease most frequently involves the skin and subcutaneous tissue followed by articular and disseminated manifestations.…”

Section: Introductionmentioning

confidence: 99%

“…Clinically, the disease most frequently involves the skin and subcutaneous tissue followed by articular and disseminated manifestations. Treatment of protothecal infections is often difficult due to resistance of the algae to multiple antimicrobial agents ( Lass-Flörl and Mayr, 2007 ; Todd et al., 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Sequencing and Analysis of the Complete Organellar Genomes of Prototheca wickerhamii

et al. 2020

View full text Add to dashboard Cite

Of the Prototheca genus, Prototheca wickerhamii has the highest clinical significance in humans. However, neither nuclear nor organellar genomes of this species were sequenced until now. The hitherto determined and analyzed mitochondrial and plastid genomes of the alleged P. wickerhamii species belong in fact to another species, recently named Prototheca xanthoria e. This study provides a first insight into the organellar genomes of a true P. wickerhamii (type strain ATCC 16529). The P. wickerhamii mitochondrion had a 53.8-kb genome, which was considerably larger than that of Prototheca ciferrii (formerly Prototheca zopfii gen. 1) and Prototheca bovis (formerly Prototheca zopfii gen. 2), yet similarly functional, with the differences in size attributable to a higher number of introns and the presence of extra unique putative genes. The 48-kb plastid genome of P. wickerhamii , compared to autotrophic Trebouxiophyceae, was highly reduced due to the elimination of the photosynthesis-related genes. The gene content of the plastid genome of P. wickerhamii was, however, very similar to other colorless Prototheca species. Plastid genome-based phylogeny reinforced the polyphyly of the genus Prototheca , with Helicosporidium and Auxenochlorella branching within clades of Prototheca species. Phylogenetic reconstruction also confirmed the close relationship of P. wickerhamii and P. xanthoriae , which is reflected in the synteny of their organellar genomes. Interestingly, the entire set of atp genes was lost in P. wickerhamii plastid genome while being preserved in P. xanthoriae .

show abstract

Medical phycology 2017

Cited by 48 publications

References 35 publications

Multiple cutaneous infections caused by Prototheca wickerhamii

Multiple cutaneous infections caused by Prototheca wickerhamii

<p>Long Term Follow-Up of <em>Prototheca</em> keratitis: A Case Report</p>

Sequencing and Analysis of the Complete Organellar Genomes of Prototheca wickerhamii

Contact Info

Product

Resources

About