2012
DOI: 10.1186/cc11849
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Abstract: IntroductionCatheter-related bloodstream infections (CRBSIs) associated with short-term central venous catheters (CVCs) in intensive care unit (ICU) patients are a major clinical problem. Bacterial colonization of the skin at the CVC insertion site is an important etiologic factor for CRBSI. The aim of this study was to assess the efficacy of medical-grade honey in reducing bacterial skin colonization at insertion sites.MethodsA prospective, single-center, open-label randomized controlled trial was performed a… Show more

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Cited by 19 publications
(21 citation statements)
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“…It consists of honey which has been modified or engineered to produce different potencies of antibacterial activity, which greatly exceed those of other honey dressings. 6,7 Interestingly, our observations are at variance with reports that another medical-grade honey did not reduce the frequency of positive skin cultures of CVC insertion sites of critically ill patients 10 and that there was considerable heterogeneity of antibacterial action between honeys from different sources. 11 This study is the first to report on the use of Surgihoney, an engineered product quite different in antimicrobial properties from other honeys, 6,7 in preventing line site colonisation and infection.…”
Section: Discussioncontrasting
confidence: 65%
“…It consists of honey which has been modified or engineered to produce different potencies of antibacterial activity, which greatly exceed those of other honey dressings. 6,7 Interestingly, our observations are at variance with reports that another medical-grade honey did not reduce the frequency of positive skin cultures of CVC insertion sites of critically ill patients 10 and that there was considerable heterogeneity of antibacterial action between honeys from different sources. 11 This study is the first to report on the use of Surgihoney, an engineered product quite different in antimicrobial properties from other honeys, 6,7 in preventing line site colonisation and infection.…”
Section: Discussioncontrasting
confidence: 65%
“…The subcutaneous course of the subclavian catheter before entry into the vein is generally longer than for the other two types. The subclavian insertion site has the lowest bacterial bioburden 25,26 and is relatively protected against dressing disruption. 27 Finally, subclavian catheters are associated with less thrombosis.…”
Section: Discussionmentioning
confidence: 99%
“…Central venous catheters (CVCs) are widely utilized in clinical practice, especially in intensive care units (ICUs) [1]. These devices are inserted so as to enable the administration of fluids, blood products, medications, parenteral nutrition, and for the performance of dialysis and central venous pressure monitoring [2, 3].…”
Section: Introductionmentioning
confidence: 99%