Medical aspects of Echinococcosis

Eckert, Johannes; Pawłowski, Z.; Dar, F.K.; Vuitton, DA; Kem, P.; Savioli, Lorenzo

doi:10.1016/0169-4758(95)80036-0

Cited by 23 publications

(16 citation statements)

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“…There are structural differences in the germinal layer between fertile and infertile hydatid cysts. This layer greatly affects the permeability of the cysts, and it has been suggested that this structural difference may affect the penetration rate of the drugs (10,31). The present results show a significant correlation between the drug concentration and the size of cysts; smaller cysts showed better permeability for both formulations.…”

Section: Discussionsupporting

confidence: 67%

Evaluation of the Hydatid Cyst Membrane Permeability of Albendazole and Albendazole Sulfoxide-Loaded Solid Lipid Nanoparticles

Soltani

Rafiei

Ramezani

et al. 2016

Jundishapur J Nat Pharm Prod

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Background: Albendazole (ABZ) and albendazole sulfoxide (ABZSO) have a basic role in the treatment of hydatid cysts. However, their poor solubility and limited intestinal permeability are the main problems in their formulation. Objectives: The preparation and characterization of ABZ and ABZSO-loaded solid lipid nanoparticles (SLNs) to increase the hydatid cyst membrane permeation by loading into SLNs. Materials and Methods: First, ABZ and ABZSO-loaded SLNs were prepared by micro emulsification and high shear homogenization. Physicochemical characterization of the formulations for particle size, polydispersity index, drug entrapment efficiency (EE) and drug loading (DL), zeta potential, particle shape, drug stability, and in vitro drug release studies were evaluated. Next, the permeability of conventional and prepared formulations on hydatid cysts was evaluated by quantifying the drug concentrations in cyst fluid using high-performance liquid chromatography (HPLC). Results: The prepared formulations showed particle sizes < 180 nm, polydispersity index values around 0.08 with narrow size distributions, a high EE of (91%) for ABZ-SLN and (94%) for ABZSO-SLN, and ideal stabilities with regard to their largely negative zeta potentials. The in vitro drug release of free drugs exhibited very fast release in the initial time, but displayed a biphasic pattern for drug-loaded SLNs. Greater permeability was achieved using the SLN preparations. Conclusions: ABZ and ABZSO achieved good physicochemical characterizations, controlled release, higher permeability and efficacy by loading into SLNs, and are promising for the treatment of this disease.

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Section: Discussionsupporting

confidence: 67%

Evaluation of the Hydatid Cyst Membrane Permeability of Albendazole and Albendazole Sulfoxide-Loaded Solid Lipid Nanoparticles

Soltani

Rafiei

Ramezani

et al. 2016

Jundishapur J Nat Pharm Prod

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“…In their review, Eckert et al (1995) noted that serology alone (i.e. in the absence of imaging techniques such as sonography) may lead to over-diagnosis of hydatid disease.…”

Section: Resultsmentioning

confidence: 99%

“…Prevalence and the pattern of transmission in any community are determined by the intermediate and ® nal hosts, the parasite strain, environmental factors, and the socio± economic and cultural characteristics of the community. The Mediterranean region and the Middle East are considered endemic areas Eckert et al , 1995;Schantz et al , 1995); prevalences of human cystic hydatidosis, measured in Algeria, Morocco, Tunisia, Italy, the former Yugoslavia, Greece, Cyprus and Israel, vary between 0.001% and 0.02% (Furth et al ., 1994;Eckert et al ., 1995). Echinococcosis accounted for 0.3% of all surgical operations and 5% of the major operations in Saudia Arabia (Malaika et al ., 1981).…”

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confidence: 99%

The seroprevalence of cystic hydatidosis in Oman

Idris

Ruppel

Gehrig-Feistel

et al. 1999

Annals of Tropical Medicine And Parasitology

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The presence of antibodies against Echinococcus granulosus in sera from 306 humans and 390 camels in Oman was investigated by indirect haemagglutination assays. Only one of the human and five of the camel sera gave positive reactions. The reactivities of the human sera were confirmed by ELISA. These results, together with isolated reports of hydatid cysts, indicate that E. granulosus is endemic in Oman, although with a low prevalence.

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“…Symptomatology is not always present and depends on the location and status of the cysts. In some cases, involution of cysts occurs after a long time, though the factors in¯uencing this event remain unknown (Eckert et al 1995). Surgery is the only possible therapy in most cases, but it is often associated with recurrence of the disease due to the development of new cysts from accidental spillage of protoscolices (relapsed hydatidosis; Little et al 1988).…”

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confidence: 99%

Phenotypic analysis of peripheral lymphocyte subpopulations in hydatid patients

Hernández

O’Connor

Mir

1999

Parasitology Research

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Peripheral T-lymphocytes were analyzed in three groups of people: (1) individuals with current liver hydatid disease (hydatid patients, n = 20), (2) persons who had undergone surgical cyst removal at least 2 years previously (recovered patients, n = 9), and (3) a control group of healthy volunteers (uninfected controls, n = 13). Group 1 was subdivided according to cyst status, relapse of disease, and the presence or absence of symptoms. Percentages of lymphocytes expressing CD3, CD4, CD8, CD56, CD25, CD45RA, CD45RO, and HLA-DR were determined. Symptomatic patients had proportionally fewer CD3+ CD8 + lymphocytes than the control group (P=0.038). Hydatid patients with active cysts had proportionally more natural killer cells (CD56 + CD8-) than the control group (P = 0.028).

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Medical aspects of Echinococcosis

Cited by 23 publications

References 0 publications

Evaluation of the Hydatid Cyst Membrane Permeability of Albendazole and Albendazole Sulfoxide-Loaded Solid Lipid Nanoparticles

Evaluation of the Hydatid Cyst Membrane Permeability of Albendazole and Albendazole Sulfoxide-Loaded Solid Lipid Nanoparticles

The seroprevalence of cystic hydatidosis in Oman

Phenotypic analysis of peripheral lymphocyte subpopulations in hydatid patients

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