1989
DOI: 10.1001/archderm.125.7.925
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Mediators of inflammation in blister fluids from patients with pemphigus vulgaris and bullous pemphigoid

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Cited by 29 publications
(9 citation statements)
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“…The binding of autoantibodies leads to activation of keratinocytes, release IL-6 and IL-8, of activation of C5 component of the complement and metalloproteinases—enzymes produced by eosinophils and neutrophils attracted to the basement membrane by selectins and integrins and chemokines [10, 11]. Chemokines are important chemoattractants for both eosinophils and neutrophils [12, 13].…”
Section: Introductionmentioning
confidence: 99%
“…The binding of autoantibodies leads to activation of keratinocytes, release IL-6 and IL-8, of activation of C5 component of the complement and metalloproteinases—enzymes produced by eosinophils and neutrophils attracted to the basement membrane by selectins and integrins and chemokines [10, 11]. Chemokines are important chemoattractants for both eosinophils and neutrophils [12, 13].…”
Section: Introductionmentioning
confidence: 99%
“…It remains to be determined whether NE cleaves BP180 at the same or similar site as mBP180, leading to generation of p561-like chemotactic peptides in patients with BP. Besides NE, MMP-9, cathepsin G, collagenase, plasmin, and plasminogen activators have also been detected in BP blister fluid and within lesional/perilesional skin sites on BP patients (Janoff, 1985; Senior and Campbell, 1983; Weiss, 1989;Gissler et al, 1992; Grando et al, 1989a; Grando et al, 1989b; Kramer and Reinartz, 1993; Oikarinen et al, 1983; Stahle-Backdahl et al, 1994; Welgus et al, 1986). MMP-9 is capable of cleaving the recombinant human BP180 NC16A domain (Stahle-Backdahl et al, 1994).…”
Section: Discussionmentioning
confidence: 99%
“…These proteinases, along with others such as plasmin and plasminogen activators, have been detected in BP blister fluid and within lesional/perilesional skin sites on BP patients (Gissler et al, 1992; Grando et al, 1989a; Grando et al, 1989b; Kramer and Reinartz, 1993; Oikarinen et al, 1983; Stahle-Backdahl et al, 1994; Welgus et al, 1986). In experimental BP, both NE and MMP-9 are required for blister formation (Liu et al, 2000a; Liu et al, 1998).…”
Section: Introductionmentioning
confidence: 99%
“…Integrin stimulating factors are cytokines, growth factors, chemokines, and other adhesion molecules, including cytokines themselves [1416]. Some literature date confirm the role of these cytokines, chemokines, and ECM enzymes in pathogenesis of BP [4, 5]. …”
Section: Discussionmentioning
confidence: 99%
“…Mast cells and neutrophils activated by the same immunological reaction migrate through walls of blood vessels with help of E and L selectins and secrete specific proteases that can digest a series of basement membrane proteins. Matrix metalloproteinases, released by inflammatory cells and keratinocytes, are finally responsible for blister formation [5, 6]. Migration of immunocompetent cells from blood vessels into foci of inflammation has several phases.…”
Section: Introductionmentioning
confidence: 99%