Mediation of Sonic Hedgehog-Induced Expression of COUP-TFII by a Protein Phosphatase

Krishnan, Venkatesh; Pereira, Fred A.; Qiu, Yuhong; Chen, Chien-Huan; Beachy, Philip A.; Tsai, Sophia Y.; Tsai, Ming Jer

doi:10.1126/science.278.5345.1947

Cited by 141 publications

(84 citation statements)

References 21 publications

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“…Motor neurons (presumably at all axial levels) are induced normally in mouse Gli1, Gli2, and Gli3 single knockouts (Ding et al, 1998;Matise et al, 1998;Park et al, 2000), and in Gli1:Gli2 and Gli1:Gli3 double mutants (Ding et al, 1998;Park et al, 2000). These data suggest that, in mouse, Shh signaling may induce motor neurons indirectly by suppressing Gli repressor function or that Gli-independent pathways may be involved (Krishnan et al, 1997). Consistent with the former, motor neurons are induced in the ventral neural tube of Shh:Gli3 double mutants, indicating that Shh signaling antagonizes the function of Gli3 in repressing motor neuron induction (Litingtung and Chiang, 2000b).…”

Section: Induction Of Branchiomotor Neuronssupporting

confidence: 57%

Turning heads: Development of vertebrate branchiomotor neurons

Chandrasekhar

2003

Developmental Dynamics

164

204

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The cranial motor neurons innervate muscles that control eye, jaw, and facial movements of the vertebrate head and parasympathetic neurons that innervate certain glands and organs. These efferent neurons develop at characteristic locations in the brainstem, and their axons exit the neural tube in well-defined trajectories to innervate target tissues. This review is focused on a subset of cranial motor neurons called the branchiomotor neurons, which innervate muscles derived from the branchial (pharyngeal) arches. First, the organization of the branchiomotor pathways in zebrafish, chick, and mouse embryos will be compared, and the underlying axon guidance mechanisms will be addressed. Next, the molecular mechanisms that generate branchiomotor neurons and specify their identities will be discussed. Finally, the caudally directed or tangential migration of facial branchiomotor neurons will be examined. Given the advances in the characterization and analysis of vertebrate genomes, we can expect rapid progress in elucidating the cellular and molecular mechanisms underlying the development of these vital neuronal networks.

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Section: Induction Of Branchiomotor Neuronssupporting

confidence: 57%

Turning heads: Development of vertebrate branchiomotor neurons

Chandrasekhar

2003

Developmental Dynamics

164

204

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“…Unlike COUP-TFI, COUP-TFII is highly expressed only in the anterior half of the cerebellum in a manner similar to that of Sonic hedgehog (Shh), which is important for cerebellar foliation (Corrales et al, 2004(Corrales et al, , 2006. Since COUP-TFII is more likely to be a downstream target of Shh signaling (Krishnan et al, 1997;Takamoto et al, 2005), it is reasonable to expect that COUP-TFII may play an important role in cerebellar development. Additionally, when one considers the temporal expression pattern of COUP-TFI and ERR␥, it is probable that they may also function during cerebellar development.…”

Section: Discussionmentioning

confidence: 99%

The expression pattern of nuclear receptors during cerebellar development

Qin

Suh

Kim

et al. 2007

Developmental Dynamics

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“…Several reports have suggested that the Hh pathway is bifurcated and that the Hh signal can be transduced independently of Ci (Krishnan et al, 1997;Lessing and Nusse, 1998;Lewis et al, 1999;Suzuki and Saigo, 2000;Gallet et al, 2000). The existence of this distal branch point has been disputed (Méthot and Basler, 2001).…”

Section: Emc Controls the Pace Of Furrow Movement Through Regulation mentioning

confidence: 99%

Extramacrochaetae imposes order on the Drosophila eye by refining the activity of the Hedgehog signaling gradient

Spratford

Kumar

2013

Development

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The compound eye of Drosophila melanogaster is configured by a differentiating wave, the morphogenetic furrow, that sweeps across the eye imaginal disc and transforms thousands of undifferentiated cells into a precisely ordered repetitive array of 800 ommatidia. The initiation of the furrow at the posterior margin of the epithelium and its subsequent movement across the eye field is controlled by the activity of the Hedgehog (Hh) signaling pathway. Differentiating photoreceptors that lie behind the furrow produce and secrete the Hh morphogen, which is captured by cells within the furrow itself. This leads to the stabilization of the full-length form of the zinc-finger transcription factor Cubitus interruptus (Ci155), the main effector of Hh signaling. Ci155 functions as a transcriptional activator of a number of downstream targets, including decapentaplegic (dpp), a TGFβ homolog. In this report, we describe a mechanism that is in place within the fly retina to limit Hh pathway activity within and ahead of the furrow. We demonstrate that the helix-loop-helix (HLH) protein Extramacrochaetae (Emc) regulates Ci155 levels. Loss of emc leads to an increase in Ci155 levels, nuclear migration, apical cell constriction and an acceleration of the furrow. We find that these roles are distinct from the bHLH protein Hairy (H), which we show restricts atonal (ato) expression ahead of the furrow. Secondary furrow initiation along the dorsal and ventral margins is blocked by the activity of the Wingless (Wg) pathway. We also show that Emc regulates and cooperates with Wg signaling to inhibit lateral furrow initiation.

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Mediation of Sonic Hedgehog-Induced Expression of COUP-TFII by a Protein Phosphatase

Cited by 141 publications

References 21 publications

Turning heads: Development of vertebrate branchiomotor neurons

Turning heads: Development of vertebrate branchiomotor neurons

The expression pattern of nuclear receptors during cerebellar development

Extramacrochaetae imposes order on the Drosophila eye by refining the activity of the Hedgehog signaling gradient

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