Meconium for Drug Testing

Methamphetamine Detection from Meconium and Amniotic Fluid in Guinea Pigs Depends on Gestational Age and Metabolism

“…Meconium test ing methods have been developed and offer the promise of more reliable samples [12,13,15]. While meconium has been suggested as a repository of drug metabolites for up to weeks before delivery [12,13], false-negative testing of meconium has been reported [13] and con firmed in this study. Still, meconium testing yields quantitative recovery more often than maternal urine testing, suggesting that the de tection rate of maternal drug use can be im proved by meconium testing after birth.…”

“…Although newborn urine testing has sever al advantages, there are important drawbacks to its use, the most significant being the high rate of false-negative results [12,13,15] simi lar to maternal urine testing. Meconium test ing methods have been developed and offer the promise of more reliable samples [12,13,15].…”

Issues in prenatal cocaine use research: Problems in identifying users and choosing an appropriate comparison group

“…As a result, these investigators recommend testing both the mother and her newborn. In contrast, work by Maynard et al (1991) as well as from our own institution (Casanova et al, in press) supports a total concordance between maternal urine and neonatal urine, especially when all specimens are collected within 24 hours of delivery.…”

Great Lakes Fish as a Source of Maternal and Fetal Exposure To Chlorinated Hydrocarbons

“…The first observation of the accumulation of compounds in meconium occurred during studies conducted by Ostrea (1980). This work led recently to several followup studies, which have verified the utility of meconium as a monitor of fetal drug exposure (Ostrea et al, 1989(Ostrea et al, , 1992Maynard et al, 1991). Compounds and their metabolites can accumulate in meconium through biliary excretion of liver metabolites or through swallowing of amniotic fluid (Ostrea et al, 1992).…”