volume 285, issue 19, P14648-14657 2010
DOI: 10.1074/jbc.m109.061853
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Amalia Ávila Figueroa, Sarah Delaney

Abstract: The expansion of a trinucleotide repeat sequence, such as CAG/CTG, has been pinpointed as the molecular basis for a number of neurodegenerative disorders. It has been proposed that as part of the expansion process, these repetitive sequences adopt non-B conformations such as hairpins. However, the prevalence of these hairpins and their contributions to the DNA expansion have not been well defined. In this work, we utilized a molecular beacon strategy to examine the stability of the (CAG) 10 hairpin and also i…

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