Mechanistic linkage between DNA adducts, mutations in oncogenes and tumorigenesis of carcinogenic environmental polycyclic aromatic hydrocarbons in strain A/J mice

1,2-dithiole-3-thione and its structural analogue oltipraz are potent inhibitors of dibenzo[a,l]pyrene-DNA adduction in female Sprague-Dawley rats

“…DMBA resulted in Ͻ10% incidence and BP was ineffective at the corresponding dose 8 . These studies and others support the use of DNA adducts as early biomarkers of cancer development 11 . Consistent with these carcinogenicity data, DBP produced substantially (5-to 100-fold) higher DNA-adduct levels than BP or DMBA in female Sprague-Dawley rats following a single intramamillary dose.…”

1,2-dithiole-3-thione and its structural analogue oltipraz are potent inhibitors of dibenzo[a,l]pyrene-DNA adduction in female Sprague-Dawley rats

“…DMBA resulted in Ͻ10% incidence and BP was ineffective at the corresponding dose 8 . These studies and others support the use of DNA adducts as early biomarkers of cancer development 11 . Consistent with these carcinogenicity data, DBP produced substantially (5-to 100-fold) higher DNA-adduct levels than BP or DMBA in female Sprague-Dawley rats following a single intramamillary dose.…”

Benzo[ b ]fluoranthene Induces Mutation Accumulation and Cancer‐Relevant Mutational Signatures in Mouse Lung Alongside Steady State Levels of Chromosome Damage in Blood

“…Lower DS-derived MFs in genic targets were also observed in bone marrow tissue obtained from MutaMouse males exposed to BaP (LeBlanc et al 2022). BbF forms DNA adducts similar to those produced by BaP (Nesnow et al 1995), which are known to block RNA synthesis, resulting in the recruitment of TCR proteins (Nadkarni et al 2016). Evidence for DS-dependent detection of TCR-mediated responses to mutagenic lesions was provided by the observation that deficiency for the xeroderma pigmentosum complementation group A (XPA) protein in mice increased the MF of aflatoxin B1 in genic but not intergenic targets (Luzadder et al 2025).…”

Partitioning Study of Polycyclic Aromatic Hydrocarbons between Water and Some Selected Water‐Insoluble Phases

“…7 These metabolites bind covalently to cellular macromolecules, including DNA, thereby causing errors in DNA replication and mutations that initiate the carcinogenic process. [8][9] This mechanism of activation, with modification in some cases, has been found to occur with all carcinogenic PAHs studied. There is also evidence that other reactive intermediates are generated by a one-electron oxidation process that can result in alkylation of DNA.…”

1,2-dithiole-3-thione and its structural analogue oltipraz are potent inhibitors of dibenzo[a,l]pyrene-DNA adduction in female Sprague-Dawley rats

“…DMBA resulted in Ͻ10% incidence and BP was ineffective at the corresponding dose 8 . These studies and others support the use of DNA adducts as early biomarkers of cancer development 11 . Consistent with these carcinogenicity data, DBP produced substantially (5-to 100-fold) higher DNA-adduct levels than BP or DMBA in female Sprague-Dawley rats following a single intramamillary dose.…”

Benzo[ b ]fluoranthene Induces Mutation Accumulation and Cancer‐Relevant Mutational Signatures in Mouse Lung Alongside Steady State Levels of Chromosome Damage in Blood

“…Lower DS-derived MFs in genic targets were also observed in bone marrow tissue obtained from MutaMouse males exposed to BaP (LeBlanc et al 2022). BbF forms DNA adducts similar to those produced by BaP (Nesnow et al 1995), which are known to block RNA synthesis, resulting in the recruitment of TCR proteins (Nadkarni et al 2016). Evidence for DS-dependent detection of TCR-mediated responses to mutagenic lesions was provided by the observation that deficiency for the xeroderma pigmentosum complementation group A (XPA) protein in mice increased the MF of aflatoxin B1 in genic but not intergenic targets (Luzadder et al 2025).…”

Partitioning Study of Polycyclic Aromatic Hydrocarbons between Water and Some Selected Water‐Insoluble Phases

“…7 These metabolites bind covalently to cellular macromolecules, including DNA, thereby causing errors in DNA replication and mutations that initiate the carcinogenic process. [8][9] This mechanism of activation, with modification in some cases, has been found to occur with all carcinogenic PAHs studied. There is also evidence that other reactive intermediates are generated by a one-electron oxidation process that can result in alkylation of DNA.…”

1,2-dithiole-3-thione and its structural analogue oltipraz are potent inhibitors of dibenzo[a,l]pyrene-DNA adduction in female Sprague-Dawley rats

“…DMBA resulted in Ͻ10% incidence and BP was ineffective at the corresponding dose 8 . These studies and others support the use of DNA adducts as early biomarkers of cancer development 11 . Consistent with these carcinogenicity data, DBP produced substantially (5-to 100-fold) higher DNA-adduct levels than BP or DMBA in female Sprague-Dawley rats following a single intramamillary dose.…”

Benzo[ b ]fluoranthene Induces Mutation Accumulation and Cancer‐Relevant Mutational Signatures in Mouse Lung Alongside Steady State Levels of Chromosome Damage in Blood

“…Lower DS-derived MFs in genic targets were also observed in bone marrow tissue obtained from MutaMouse males exposed to BaP (LeBlanc et al 2022). BbF forms DNA adducts similar to those produced by BaP (Nesnow et al 1995), which are known to block RNA synthesis, resulting in the recruitment of TCR proteins (Nadkarni et al 2016). Evidence for DS-dependent detection of TCR-mediated responses to mutagenic lesions was provided by the observation that deficiency for the xeroderma pigmentosum complementation group A (XPA) protein in mice increased the MF of aflatoxin B1 in genic but not intergenic targets (Luzadder et al 2025).…”

Partitioning Study of Polycyclic Aromatic Hydrocarbons between Water and Some Selected Water‐Insoluble Phases

“…7 These metabolites bind covalently to cellular macromolecules, including DNA, thereby causing errors in DNA replication and mutations that initiate the carcinogenic process. [8][9] This mechanism of activation, with modification in some cases, has been found to occur with all carcinogenic PAHs studied. There is also evidence that other reactive intermediates are generated by a one-electron oxidation process that can result in alkylation of DNA.…”