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Cited by 51 publications
(31 citation statements)
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References 85 publications
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“…In the last decades, the long-term impetus has promoted innovative attempts to tackle the elusive enigma with multidisciplinary approaches. With accumulating evidence of the multiple advantages boosted by allosteric modulation, it has attracted an ever-growing interest in pharmaceutics, and consequently, the combination of orthosteric and allosteric agents is emerging as a revolutionary strategy to overcome resistance, as exemplified by the growing number of successful cases [ 74 , 75 , 76 , 77 , 78 , 79 ]. Accordingly, a series of orthosteric-allosteric drug combinations have proceeded into clinical trials, mostly involving oncology, viruses, and autoimmune disorders [ 17 ].…”
Section: Discussionmentioning
confidence: 99%
“…In the last decades, the long-term impetus has promoted innovative attempts to tackle the elusive enigma with multidisciplinary approaches. With accumulating evidence of the multiple advantages boosted by allosteric modulation, it has attracted an ever-growing interest in pharmaceutics, and consequently, the combination of orthosteric and allosteric agents is emerging as a revolutionary strategy to overcome resistance, as exemplified by the growing number of successful cases [ 74 , 75 , 76 , 77 , 78 , 79 ]. Accordingly, a series of orthosteric-allosteric drug combinations have proceeded into clinical trials, mostly involving oncology, viruses, and autoimmune disorders [ 17 ].…”
Section: Discussionmentioning
confidence: 99%
“…Upon the inhibitor-protein interactions, the protein structures will be subtly altered, which triggers the surface conformational changes, thereby facilitating the more compact binding of the inhibitors. Importantly, the rapid advances in structural biology and computational biology have enabled the in-depth exploration into the sophisticated conformational ensembles of PPI systems (Qiu et al, 2020 ; Wang et al, 2021 ). With the help of techniques such as molecular dynamics (MD) simulations (Yang et al, 2019 ), the transient intermediate PPI interface conformations can be probed, based on which further structure-based rational inhibitor design can be more easily carried out (Tavakoli and Ganjalikhany, 2019 ; Yao et al, 2020 ).…”
Section: Discussionmentioning
confidence: 99%
“…Also, it gave us a clue to achieve mutant and isoform selectivity by directly targeting the mutated RAS isoform, instead of the upstream or downstream proteins. Moreover, since the cryptic allosteric cavities on the surface of K-RAS WT and K-RAS G12C are mutant-distinct 39 , 90 , 91 , it is quite possible that phosphorylation may induce novel cryptic sites for allosteric drug development.…”
Section: Discussionmentioning
confidence: 99%