Mechanistic aspects of the interaction of intercalating metal complexes with nucleic acids

Pyrophosphate-bridged complexes with picomolar toxicity

“…It has been shown that metal-phenanthroline complexes interact non-covalently with DNA according to three basic models: (i) electrostatic (ii) minor groove binding and (iii) partial penetration of phen residues between DNA base pairs through groove binding [61]. To further investigate the mode of DNA interaction for these complexes, circular dichroism (CD) experiments were conducted [62,63].…”

Dinuclear organoiridium(III) mono- and bis-intercalators with rigid bridging ligands: Synthesis, cytotoxicity and DNA binding

“…caesius, that is employed for the treatment of a wide range of human cancerous malignancies, including acute lymphoblastic leukemia, malignant lymphoma, breast carcinoma and ovarian carcinoma [2]. In the light of this success story, the well characterised ability of octahedral transition metal polypyridyl complexes such as [Ru(phen) 2 (dppz)] 2+ to target specific DNA base sequences through intercalative binding [3][4][5] has also prompted studies of their potential as anticancer agents. Unfortunately, octahedral metallointercalators containing two or three polypyridyl ligands have not shown particular promise in this respect [1], although [RhCl 2 (dppz)(phen)]Cl does exhibit significant cytotoxicity towards human tumour cells following irradiation at 311 nm [6].…”

“…Me 5 )Ir(dpq)} 2 (l-4,4 0 -bpy)](CF 3 SO 3 ) 4. (2)Preparation as for 1 with the ligands dpq (23 5. )Ir(dpq)-H] + .…”

Transition Metal Ion Complexes of N-alkylguanines

“…[5]). In addition, inorganic nanoparticles [6], metallo-intercalators and metalloinsertors [7,8] and metallocenes [9] as derivatives or carriers of nucleic acids have recently been reviewed. Finally, this review only provides a limited overview of the medicinal aspects of platinumbased anticancer agents as they have been comprehensively covered in detail elsewhere [10][11][12][13][14][15][16][17].…”