Mechanisms Underlying the Inhibition of KV1.3 Channel by Scorpion Toxin ImKTX58

Abstract

α-KTX, alpha-potassium channel toxin peptides; ADWX-1, autoimmune drug from Wenxin group; APC, anterior piriform cortex; BK channel, large conductance voltage and Ca 2+ -activated potassium channel; CS, cysteine-stabilized; ChTX, Charybdotoxin; DMEM, Dulbecco's modified Eagle's medium; DRG, dorsal root ganglion; E. coli, Escherichia coli; GPCR, G protein-coupled receptor; HPLC, High Performance Liquid Chromatography; IC 50 , concentration of half-maximal inhibition; IL-2, interleukin-2; ImKTX58, number 58 potassium channel toxin peptide identified from the venom gland cDNA library of Isometrus maculatus; ImKTX88, number 88 potassium channel toxin peptide identified from the venom gland cDNA library of Isometrus maculatus; κ-BUTX-Im1a, kappa-Buthitoxin-Im1a; Kv channel, voltage-gated potassium channel; LmKTX10, number 10 potassium channel This article has not been copyedited and formatted. The final version may differ from this version.

Diterpenoids from Euphorbia fischeriana with Kv1.3 Inhibitory Activity

“…Crystal Data for Euphofischeroid B (2). C 29 H 38 O 7 , M = 498.59 g/ mol, orthorhombic, space group P2 1 2 1 2 1 (no.…”

“…Autoimmune diseases are stimulated by excessive immune responses originating from an immune malfunction. Such health conditions affect physiological and psychological human health all around the world. , Although commonly used autoimmune drugs, such as steroids and cyclophosphamide, can alleviate symptoms promoted by autoimmune responses, the lack of selectivity makes these drugs of limited clinical effectiveness to treat conditions resulting from immune responses and increases the chances of occurring secondary infections and serious side effects . Therefore, it is urgent to develop therapeutic targets to treat effectively autoimmune diseases without affecting the normal protective immune system.…”