Mechanisms of spermidine-induced autophagy and geroprotection

Simon, Anna Katharina; Bergmann, Martina; Eisenberg, Tobias; Kroemer, Guido; Madeo, Frank

doi:10.1038/s43587-022-00322-9

Cited by 56 publications

(29 citation statements)

References 225 publications

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“…For instance, proper regulation of autophagy is an indispensable mechanism for the health-promoting effects of aspirin, particularly in relation to blood leukocyte recycling, CR mimicking, and obesity prevention (Castoldi et al, 2020). Additionally, rapamycin (Nie et al, 2021), polyphenols (M. Wu et al, 2021), and spermidine (Hofer et al, 2022) have been shown…”

Section: Compromised (Macro)autophagymentioning

confidence: 99%

“…For instance, proper regulation of autophagy is an indispensable mechanism for the health‐promoting effects of aspirin, particularly in relation to blood leukocyte recycling, CR mimicking, and obesity prevention (Castoldi et al., 2020). Additionally, rapamycin (Nie et al., 2021), polyphenols (M. Wu et al., 2021), and spermidine (Hofer et al., 2022) have been shown to extend lifespan through the induction of autophagy (Hansen et al., 2018; Kitada & Koya, 2021). Selected examples of plant secondary metabolites that modulate autophagy‐related molecular pathways are listed in Table 1.…”

Section: “New” Hallmarks Of Aging—longevity Perspectivementioning

confidence: 99%

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Nurturing longevity through natural compounds: Where do we stand, and where do we go?

Todorova,

Savova,

Mihaylova

et al. 2024

Food Frontiers

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The revolution in aging research through the past decade has driven the progress in interventions that promote longevity. Dissection of the “old” hallmarks of aging has provided solid data for the definition of at least three “new” ones, opening avenues for the development of novel hallmark‐targeted pro‐longevity approaches. The quest for geroprotectors is of enormous interest with the ultimate goal of finding the alchemical stone that induces healthy aging and increases lifespan, pushing the limits of human longevity or even uncovering the absence of such limits. Several of the well‐appreciated geroprotectors that are recognized as longevity promoters are of natural origin such as metformin, resveratrol, aspirin, and spermidine. As the search for pharmacological modulators of healthspan and lifespan continues, numerous studies are focusing on the potential of plant secondary metabolites. The current review attempts to critically assess the available interventions and the breakthrough discoveries in the field of longevity research over the past decade. Correspondingly, novel approaches targeting the hallmarks of aging have been outlined, and the future goals in longevity research have been enlightened. Special emphasis has been placed on the potential of plant‐derived compounds as pro‐longevity agents.

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Section: Compromised (Macro)autophagymentioning

confidence: 99%

Section: “New” Hallmarks Of Aging—longevity Perspectivementioning

confidence: 99%

Nurturing longevity through natural compounds: Where do we stand, and where do we go?

Todorova,

Savova,

Mihaylova

et al. 2024

Food Frontiers

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“…[87] Spermidine stimulates autophagy in mammals via posttranslational hypusination of eukaryotic initiation factor 5A (eIF5A), which is essential for synthesizing the autophagy transcription factor TFEB. [88,89] Spermidine reportedly extends the lifespan of mice in a manner dependent on the microtubule-associated protein MPA1S, which positively regulates autophagy. [90] Research on Drosophila reported that spermidine-induced lifespan extension does not occur in strains with reduced insulin/IGF signaling because of the deletion of three insulin-like peptides and thus may be involved in insulin/IGF signaling.…”

Section: Spermidinementioning

confidence: 99%

Low‐Molecular Weight Compounds that Extend the Chronological Lifespan of Yeasts, Saccharomyces cerevisiae, and Schizosaccharomyces pombe

Ohtsuka,

Shimasaki,

Aiba

2024

Advanced Biology

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Yeast is an excellent model organism for research for regulating aging and lifespan, and the studies have made many contributions to date, including identifying various factors and signaling pathways related to aging and lifespan. More than 20 years have passed since molecular biological perspectives are adopted in this research field, and intracellular factors and signal pathways that control aging and lifespan have evolutionarily conserved from yeast to mammals. Furthermore, these findings have been applied to control the aging and lifespan of various model organisms by adjustment of the nutritional environment, genetic manipulation, and drug treatment using low‐molecular weight compounds. Among these, drug treatment is easier than the other methods, and research into drugs that regulate aging and lifespan is consequently expected to become more active. Chronological lifespan, a definition of yeast lifespan, refers to the survival period of a cell population under nondividing conditions. Herein, low‐molecular weight compounds are summarized that extend the chronological lifespan of Saccharomyces cerevisiae and Schizosaccharomyces pombe, along with their intracellular functions. The low‐molecular weight compounds are also discussed that extend the lifespan of other model organisms. Compounds that have so far only been studied in yeast may soon extend lifespan in other organisms.

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“…Finally, the organic phase was dried over anhydrous Na 2 SO 4 and concentrated under vacuum to give the yellow oil, 6 (4.50 g, 95%). 1 (7). A round-bottom flask was charged with 6 (3.00 g, 9.13 mmol) dissolved in THF (30 mL, 3.3 mL•mmol −1 ).…”

Section: N-(2-aminoethyl)-n′-[2-(benzylamino)ethyl]ethane-12-diamine (2ementioning

confidence: 99%

“…The best-known members of such naturally occurring polyamines are likely the diamine putrescine (1,4-diaminobutane), together with the triamine spermidine and tetraamine spermine. Various relevant biological roles have been attributed to these linear saturated polyamines (LSPs), such as key agents in the division of eukaryotic cells or in the synthesis of proteins and nucleic acids, − which make polyamine synthesis a field of interest regarding their potential biological and pharmacological roles as antineoplastics in cancer therapy, , as agents against neurodegenerative disorders (Alzheimer’s and Parkinson’s diseases or amyotrophic lateral sclerosis), − or as antimicrobial drugs …”

Section: Introductionmentioning

confidence: 99%

Sequential Nitrile Amidination–Reduction as a Straightforward Procedure to Selective Linear Polyamine Preparation

Peñas-Sanjuán,

Chica-Armenteros,

Cruz-Sánchez

et al. 2023

J. Org. Chem.

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A straightforward strategy toward the efficient synthesis of linear saturated polyamines containing 1,2-diaminoethane and/or 1,3-diaminopropane fragments has been developed. The procedure is based on the chemistry of 5- and 6-membered cyclic amidines, including their efficient synthesis from nitrile precursors and subsequent chemoselective reductive-opening by a borane–dimethyl sulfide complex. This two-step procedure provides a robust methodology for the synthesis of linear polyamine skeletons under nonharsh conditions and free of using selective protective groups or tedious workups.

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Mechanisms of spermidine-induced autophagy and geroprotection

Cited by 56 publications

References 225 publications

Nurturing longevity through natural compounds: Where do we stand, and where do we go?

Nurturing longevity through natural compounds: Where do we stand, and where do we go?

Low‐Molecular Weight Compounds that Extend the Chronological Lifespan of Yeasts, Saccharomyces cerevisiae, and Schizosaccharomyces pombe

Sequential Nitrile Amidination–Reduction as a Straightforward Procedure to Selective Linear Polyamine Preparation

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