2016
DOI: 10.1038/srep27512
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Abstract: Patients with tumors that metastasize to bone frequently suffer from debilitating pain, and effective therapies for treating bone cancer are lacking. This study employed a novel strategy in which herpes simplex virus (HSV) carrying a small interfering RNA (siRNA) targeting platelet-derived growth factor (PDGF) was used to alleviate bone cancer pain. HSV carrying PDGF siRNA was established and intrathecally injected into the cavum subarachnoidale of animals suffering from bone cancer pain and animals in the neg… Show more

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Cited by 19 publications
(16 citation statements)
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“…The same effect was observed for PDGF-B and ICAM-1 expression in normal spinal cords. The PDGF-B IR signal was mainly colocalized with astrocytes in normal or injured spinal cords, and several studies have suggested that the astrocytes express PDGF-B after stimulation (Bethel-Brown et al, 2012 ; Xu et al, 2016 ). Therefore, PDGF-B expression in normal or injured spinal cords may be related to astrocyte activation.…”
Section: Discussionmentioning
confidence: 98%
“…The same effect was observed for PDGF-B and ICAM-1 expression in normal spinal cords. The PDGF-B IR signal was mainly colocalized with astrocytes in normal or injured spinal cords, and several studies have suggested that the astrocytes express PDGF-B after stimulation (Bethel-Brown et al, 2012 ; Xu et al, 2016 ). Therefore, PDGF-B expression in normal or injured spinal cords may be related to astrocyte activation.…”
Section: Discussionmentioning
confidence: 98%
“…PDGF is involved in the development of bone cancer pain through AKT-ERK signaling pathway. 24 Recently, PDGFRβ in spinal cord is activated after chronic morphine administration, and antagonizing PDGFRβ could reverse morphine tolerance. 15 Here, we explored the intrinsic mechanism of this phenomenon and provided the first evidence of the contribution of PDGFRβ to microglia activation in morphine tolerance.…”
Section: Discussionmentioning
confidence: 99%
“…Previous reports have shown the involvement of PDGFR-α and PDGF in chronic neuropathic or cancer pain. 48,69 Platelet-derived growth factor is released from injured spinal nerves and contributes to neuropathic pain. 22 However, the biophysical mechanisms underlying the effect of PDGF in neuropathic pain are not known.…”
Section: Discussionmentioning
confidence: 99%