volume 66, issue 7, P4209-4219 1992
DOI: 10.1128/jvi.66.7.4209-4219.1992
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C M Bentivoglio, J Zhu, C N Cole

Abstract: Mutations at multiple sites within the simian virus 40 (SV40) early region yield large T antigens which interfere trans dominantly with the replicative activities of wild-type T antigen. A series of experiments were conducted to study possible mechanisms of interference with SV40 DNA replication caused by these mutant T antigens. First, the levels of wild-type T antigen expression in cells cotransfected with wild-type and mutant SV40 DNAs were examined; approximately equal levels of wild-type T antigen were se…

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