Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis

Mauch, Renan Marrichi; Jensen, Peter Østrup; Moser, Claus; Levy, Carlos Emílio; Høiby, Niels

doi:10.1016/j.jcf.2017.08.012

Cited by 42 publications

(45 citation statements)

References 77 publications

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“…Infection of the CF airway with Pa starts with planktonic (free living), variants often originating from the environment. Over time, as bacteria adapt to the CF airway, they environment, they form a biofilm (98). In this section we address the contribution of Pf phages to Pa biofilm formation and to other phenotypes involved in Pa pathogenicity.…”

Section: Pf Effects On Pa Phenotypes and Fitnessmentioning

confidence: 99%

Pf Bacteriophage and Their Impact on Pseudomonas Virulence, Mammalian Immunity, and Chronic Infections

et al. 2020

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Pf bacteriophage are temperate phages that infect the bacterium Pseudomonas aeruginosa, a major cause of chronic lung infections in cystic fibrosis (CF) and other settings. Pf and other temperate phages have evolved complex, mutualistic relationships with their bacterial hosts that impact both bacterial phenotypes and chronic infection. We and others have reported that Pf phages are a virulence factor that promote the pathogenesis of P. aeruginosa infections in animal models and are associated with worse skin and lung infections in humans. Here we review the biology of Pf phage and what is known about its contributions to pathogenesis and clinical disease. First, we review the structure, genetics, and epidemiology of Pf phage. Next, we address the diverse and surprising ways that Pf phages contribute to P. aeruginosa phenotypes including effects on biofilm formation, antibiotic resistance, and motility. Then, we cover data indicating that Pf phages suppress mammalian immunity at sites of bacterial infection. Finally, we discuss recent literature implicating Pf in chronic P. aeruginosa infections in CF and other settings. Together, these reports suggest that Pf bacteriophage have direct effects on P. aeruginosa infections and that temperate phages are an exciting frontier in microbiology, immunology, and human health.

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Section: Pf Effects On Pa Phenotypes and Fitnessmentioning

confidence: 99%

Pf Bacteriophage and Their Impact on Pseudomonas Virulence, Mammalian Immunity, and Chronic Infections

et al. 2020

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“…It has been reported that swarming motility is essential for biofilm development (Shrout et al, ). Moreover, the biofilm mode of growth is proposed to occur in the lungs of chronically P. aeruginosa ‐infected cystic fibrosis patients and bacterial cells are thus protected from antibiotic treatment and the immune response (Høiby et al, ; Mauch, Jensen, Moser, Levy, & Hoiby, ). The antimicrobial effects of Asian ginseng, American ginseng, and notoginseng and the possible underlying mechanisms are summarized in Table .…”

Section: Antimicrobial Propertiesmentioning

confidence: 99%

Antimicrobial activities of Asian ginseng, American ginseng, and notoginseng

Wang

Huang

Yin

et al. 2019

Phytotherapy Research

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Asian ginseng (Panax ginseng C.A. Meyer), American ginseng (Panax quinquefolius) and notoginseng (Panax notoginseng) are the three most commonly used ginseng botanicals in the world. With the increasing interests on antimicrobial properties of plants, the antimicrobial activities of ginseng species have been investigated by a number of researchers worldwide. This overview interprets our present knowledge of the antimicrobial activities of the three ginseng species and some of their bioactive components against pathogenic bacteria (Pseudomonas aeruginosa, Helicobacter pylori, Staphylococcus aureus, Escherichia coli, Propionibacterium acnes, et al.) and fungi (Candida albicans, Fusarium oxysporum, et al). Ginsenosides, polysaccharides, essential oil, proteins, and panaxytriol are all might responsible for the antimicrobial activities of ginseng. The antimicrobial mechanisms of ginseng components could be summarized to the following points: (a) inhibit the microbial motility and quorum-sensing ability; (b) affect the formation of biofilms and destroy the mature biofilms, which can weaken the infection ability of the microbes; (c) perturb membrane lipid bilayers, thus causing the formation of pores, leakages of cell constituents and eventually cell death; (d) stimulate of the immune system and attenuate microbes induced apoptosis, inflammation, and DNA damages, which can protect or help the host fight against microbial infections; and (e) inhibit the efflux of antibiotics that can descend the drug resistance of the microbial. The collected information might facilitate and guide further studies needed to optimize the use of ginseng and their components to improve microbial food safety and prevent or treat animal and human infections.

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“…A vicious cycle of persistent inflammation and infections affects severely the pulmonary parenchyma (Nichols and Chmiel, 2015). The main respiratory pathogens found in CF patients are Pseudomonas aeruginosa (Hoiby, 2011;Mauch et al, 2018), Staphylococcus aureus (Schwerdt et al, 2018;Wong et al, 2013), and Burkholderia cepacia (Regan and Bhatt, 2016). Eventually lung transplantation is needed for CF patients with end-stage lung disease (Snell et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Extracellular pH and lung infections in cystic fibrosis

Massip-Copiz

Santa‐Coloma

2018

European Journal of Cell Biology

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Cystic fibrosis (CF) is an autosomal recessive disease caused by CFTR mutations. It is characterized by high NaCl concentration in sweat and the production of a thick and sticky mucus, occluding secretory ducts, intestine and airways, accompanied by chronic inflammation and infections of the lungs. This causes a progressive and lethal decline in lung function. Therefore, finding the mechanisms driving the high susceptibility to lung infections has been a key issue. For decades the prevalent hypothesis was that a reduced airway surface liquid (ASL) volume and composition, and the consequent increased mucus concentration (dehydration), create an environment favoring infections. However, a few years ago, in a pig model of CF, the Na/K concentrations and the ASL volume were found intact. Immediately a different hypothesis arose, postulating a reduced ASL pH as the cause for the increased susceptibility to infections, due to a diminished bicarbonate secretion through CFTR. Noteworthy, a recent report found normal ASL pH values in CF children and in cultured primary airway cells, challenging the ASL pH hypothesis. On the other hand, recent evidences revitalized the hypothesis of a reduced ASL secretion. Thus, the role of the ASL pH in the CF is still a controversial matter. In this review we discuss the basis that sustain the role of CFTR in modulating the extracellular pH, and the recent results sustaining the different points of view. Finding the mechanisms of CFTR signaling that determine the susceptibility to infections is crucial to understand the pathophysiology of CF and related lung diseases.

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Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis

Cited by 42 publications

References 77 publications

Pf Bacteriophage and Their Impact on Pseudomonas Virulence, Mammalian Immunity, and Chronic Infections

Pf Bacteriophage and Their Impact on Pseudomonas Virulence, Mammalian Immunity, and Chronic Infections

Antimicrobial activities of Asian ginseng, American ginseng, and notoginseng

Extracellular pH and lung infections in cystic fibrosis

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