1996
DOI: 10.1016/0735-1097(95)00403-3 View full text |Buy / Rent full text
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Abstract: The distinct patterns of regurgitant flow seen in these patients with mitral prosthetic hemolysis were associated with rapid acceleration and deceleration or high peak shear rates, or both. The nature of the flow disturbance produced by the prosthetic regurgitant lesion and the resultant increase in shear stress are more important than the site of origin of the flow disturbance in producing clinical hemolysis.

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“…However, anemia due to hemolysis is rare unless there is prosthetic regurgitation [37,38]. Hemolysis may occur with either central or paravalvular regurgitation due to rapid acceleration and deceleration or high-peak shear rates [39], and has even been reported after mitral valve repair [40].…”
Section: Hemolytic Anemiamentioning
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“…However, anemia due to hemolysis is rare unless there is prosthetic regurgitation [37,38]. Hemolysis may occur with either central or paravalvular regurgitation due to rapid acceleration and deceleration or high-peak shear rates [39], and has even been reported after mitral valve repair [40].…”
Section: Hemolytic Anemiamentioning
“…Higher peak regurgitant flows 23 and decreased regurgitant volumes 24 have been associated with an increase in hemolysis. Extensive in vitro hemolysis testing is planned to determine the hemolytic potential of these valves when incorporated within a PVAD.…”
Section: Future Testingmentioning
“…5 Rapid acceleration, fragmentation and collision jets are associated with high shear stress, and may cause mitral prosthetic hemolysis, whereas free and slow deceleration jets are not. 1 The mechanism of hemolysis observed after mitral valve repair most commonly involves direct collision of the regurgitation jet with an annuloplasty ring and appears to be independent of the severity of mitral regurgitation. 2 In the present case, a high velocity, paravalvular mitral regurgitation jet collided with the Duran ring and may have caused the hemolysis.…”
Section: Discussionmentioning