2013
DOI: 10.1021/la4012789
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Abstract: Adsorption of fibrinogen was theoretically studied using the three-dimensional random sequential adsorption (RSA) model. Fibrinogen molecule shape was approximated by the bead model considering the presence of flexible side arms. Various cases were considered inter alia, the side-on adsorption mechanisms and the simultaneous side-on/end-on adsorption mechanism. The latter mechanisms is pertinent to fibrinogen adsorption at lower pH (below isoelectric point of 5.8) where the entire molecule is positively charge… Show more

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Cited by 45 publications
(68 citation statements)
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“…This effect is physically due to the overlapping of the water 'atmospheres' surrounding each molecule. This phenomenon is analogous to the overlapping of exclusion areas (volumes) of adsorbed molecules pertinent to the random sequential adsorption model [40][41][42] and was interpreted along this line by Bingen et al [23] using various hydration models.…”
Section: The Kinetics Of Fibrinogen Adsorption -Low Coverage Regimementioning
confidence: 71%
See 2 more Smart Citations
“…This effect is physically due to the overlapping of the water 'atmospheres' surrounding each molecule. This phenomenon is analogous to the overlapping of exclusion areas (volumes) of adsorbed molecules pertinent to the random sequential adsorption model [40][41][42] and was interpreted along this line by Bingen et al [23] using various hydration models.…”
Section: The Kinetics Of Fibrinogen Adsorption -Low Coverage Regimementioning
confidence: 71%
“…7 were theoretically interpreted in terms of the extended random sequential adsorption model developed in Refs. [40][41][42]. This is an universal approach that allows one to theoretically predict the blocking function and the maximum coverage for various adsorption mechanisms of fibrinogen molecules.…”
Section: The Kinetics Of Fibrinogen Adsorption -Low Coverage Regimementioning
confidence: 99%
See 1 more Smart Citation
“…The two end domains have diameters of 65 Å and the central 50 Å 23 . Fibrinogen is present in the blood plasma at an average concentration of around 3 mg mL -1 (3000 ppm) and the overall molecular weight is around 340 kDa 24 . The protein is actually a dimer comprising two triplets of polypeptide chains, known as the Aα, Bβ and γ chains, joined in the central domain via disulfide bridges.…”
Section: Introductionmentioning
confidence: 99%
“…In recent studies RSA has also been successfully used for modeling complex particles using coarse-grain approximation [8][9][10][11]. For example, a coarse-grain fibrinogen model successfully explains the density of adsorbed proteins for a wide range of experimental conditions [12][13][14].…”
Section: Introductionmentioning
confidence: 99%