Mechanisms of Action of Nutritionally Rich
            <i>Hibiscus sabdariffa's</i>
            Therapeutic Uses in Major Common Chronic Diseases: A Literature Review

Amos, Amylee; Khiatah, Bashar

doi:10.1080/07315724.2020.1848662

Cited by 12 publications

(10 citation statements)

References 63 publications

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“…Hibiscus sabdariffa L. antihypertensive potential derives from its vasodilator activity, diuretic effectiveness, ACE inhibiting functionality, adipocyte differentiation suppressing functionality, heart rate lowering capability, and anti-inflammatory mechanistics (Amos & Khiatah, 2022). The anthocyanins and hibiscus acid in hibiscus have been linked to its antihypertensive properties (Salem et al, 2020).…”

Section: Compoundmentioning

confidence: 99%

Natural angiotensin converting enzyme inhibitors: A safeguard against hypertension, respiratory distress syndrome, and chronic kidney diseases

Khaled,

Ahmed,

Mamdouh

et al. 2023

Phytotherapy Research

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Hypertension is a serious concern as it is one of the causes of kideny failure and pulmonary fibrosis. An important therapeutic strategy for treating chronic hypertension is to inhibit the angiotensin converting enzyme (ACE). ACE inhibition reduces kidney damage, pulmonary artery pressure, and high blood pressure. Due to their high efficacy and low risk of side effects, natural renin‐angiotensin system inhibitors have drawn increasing attention over the past decades. Alkaloids, amino acids, anthocyanidins, flavonoids, glucosinolates, isoflavonoids, phenolic acids, polyphenolics, and triterpenoids are among the bioactive metabolites pocessing an impressive ACE inhibitory activity. Many herbs including Rosmarinus officinalis, Hibiscus sabdariffa, Curcuma longa, Rauwolfia serpentina, Emblica officinalis, Cynara scolymus, Punica granatum, Mucuna pruriens, Capsicum annuum, and Moringa olifera were found having ACE inhibitory activities comparable to captopril and enalpril. These enticing natural ACE inhibitors deserve to be a safeguard medicine against hypertension, respiratory distress syndrome, and chronic kidney diseases. More clinical trials are required before new natural compounds and herbs can be used to treat chronic hypertension and its ramifications, such as respiratory distress syndrome and kidney failure.

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Section: Compoundmentioning

confidence: 99%

Natural angiotensin converting enzyme inhibitors: A safeguard against hypertension, respiratory distress syndrome, and chronic kidney diseases

Khaled,

Ahmed,

Mamdouh

et al. 2023

Phytotherapy Research

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“…Hibiscus sabdariffa (roselle) is a plant belonging to the Malvaceae family, growing wild in tropical climates [ 1 ]. Due to the high content of pharmacologically active compounds and thus good healing properties, roselle has been well known and widely used in traditional medicine for thousands of years [ 2 , 3 ]. In addition to its medical use, roselle is widely used in the culinary arts as a source of nutrients or as a natural dye that is used in the food and textile industries [ 4 , 5 , 6 ].…”

Section: Hibiscus Sabdariffa —Characteristicmentioning

confidence: 99%

“…Today it is cultivated almost everywhere in the tropics and subtropics; in Mexico, India, Saudi Arabia, China, Vietnam, Sudan, Egypt, Malaysia, Indonesia, the Philippines, and Nigeria [ 7 ]. It is known by many names depending on the geographical area, for example Karkadé, Roselle, Jamaica, Sorrel, and many others [ 3 ].…”

Section: Hibiscus Sabdariffa —Characteristicmentioning

confidence: 99%

Hibiscus sabdariffa in Diabetes Prevention and Treatment—Does It Work? An Evidence-Based Review

Jamrozik

Borymska

Kaczmarczyk-Sedlak

2022

Foods

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Diabetes is currently a global health problem that is already reported as an epidemic. This metabolic disease, characterized by a disturbance in the carbohydrate, protein, and lipid metabolism, is often accompanied by disorders of several organs. Its treatment is expensive and often difficult to control. Therefore, it seems necessary to search for new drugs and solutions to facilitate therapy and reduce treatment costs. Herbal medicines are becoming more and more popular. Hibiscus sabdariffa (roselle) is a plant that grows wild in a tropical climate. It has been used in folk medicine for thousands of years. Thanks to the numerous active compounds, including polyphenols, polysaccharides, organic acids, or pectins, it is reported to exhibit hypoglycemic, antioxidant, hypotensive, and anti-lipidemic activities and numerous indirect effects that are related to them. The aim of this review was to update the knowledge about the therapeutic effects of roselle in diabetes and its comorbidities based on in vitro, animal, and human studies. After a careful analysis of the scientific literature, it can be stated that roselle is a promising product that can be used either on its own or as an addition to the conventional treatment regimens to prevent or treat diabetes and its accompanying diseases.

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“…Roselle is used in folk medicines. The potential properties such as anti-obesity [ 231 , 232 , 233 ], autophagy-inducing activity [ 234 ], antioxidant, anti-inflammatory, anti-hypertensive, anti-hyperglycemic properties indicate the health-promoting and protective health benefits of Roselle [ 234 , 235 ].…”

Section: Herbal Teas and Autophagymentioning

confidence: 99%

Role of Herbal Teas in Regulating Cellular Homeostasis and Autophagy and Their Implications in Regulating Overall Health

et al. 2021

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Tea is one of the most popular and widely consumed beverages worldwide, and possesses numerous potential health benefits. Herbal teas are well-known to contain an abundance of polyphenol antioxidants and other ingredients, thereby implicating protection and treatment against various ailments, and maintaining overall health in humans, although their mechanisms of action have not yet been fully identified. Autophagy is a conserved mechanism present in organisms that maintains basal cellular homeostasis and is essential in mediating the pathogenesis of several diseases, including cancer, type II diabetes, obesity, and Alzheimer’s disease. The increasing prevalence of these diseases, which could be attributed to the imbalance in the level of autophagy, presents a considerable challenge in the healthcare industry. Natural medicine stands as an effective, safe, and economical alternative in balancing autophagy and maintaining homeostasis. Tea is a part of the diet for many people, and it could mediate autophagy as well. Here, we aim to provide an updated overview of popular herbal teas’ health-promoting and disease healing properties and in-depth information on their relation to autophagy and its related signaling molecules. The present review sheds more light on the significance of herbal teas in regulating autophagy, thereby improving overall health.

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Mechanisms of Action of Nutritionally Rich Hibiscus sabdariffa's Therapeutic Uses in Major Common Chronic Diseases: A Literature Review

Cited by 12 publications

References 63 publications

Natural angiotensin converting enzyme inhibitors: A safeguard against hypertension, respiratory distress syndrome, and chronic kidney diseases

Natural angiotensin converting enzyme inhibitors: A safeguard against hypertension, respiratory distress syndrome, and chronic kidney diseases

Hibiscus sabdariffa in Diabetes Prevention and Treatment—Does It Work? An Evidence-Based Review

Role of Herbal Teas in Regulating Cellular Homeostasis and Autophagy and Their Implications in Regulating Overall Health

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