Biochemical Pharmacology volume 79, issue 3, P516-523 2010 DOI: 10.1016/j.bcp.2009.09.013 View full text
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Han Liu, Hui Li, Liyuan Guo, Mengsen Li, Chaoying Li, Shanshan Wang, Wei Jiang, Xinhua Liu, Michael A. McNutt, Gang Li

Abstract: Despite the substantial progress made in understanding initiation expression of the MOR gene in lymphocytes, the signal pathway associated with MOR gene transcription remains to be better defined. As the phosphatidylinositol 3-kinase (PI3K)/AKT pathway can mediate diverse biological responses and is crucial for optimal immune responses and lymphocyte development, this study was undertaken to delineate the role of PI3K/AKT signaling in expression of the MOR gene in CEM x174 cells. The data show that morphine tr…

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