Mechanisms by Which Different Functional States of Mitochondria Define Yeast Longevity

Beach, Adam; Leonov, Anna; Arlia-Ciommo, Anthony; Svistkova, Veronika; Lutchman, Vicky; Titorenko, Vladimir I.

doi:10.3390/ijms16035528

Cited by 28 publications

(35 citation statements)

References 218 publications

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“…A body of evidence supports the notion that LCA slows down yeast chronological aging because it instigates specific changes in the concentrations of mitochondrial membrane phospholipids (178-183). This evidence has recently been thoroughly discussed (184)(185)(186)(187)(188). We therefore briefly summarize below the data confirming that certain LCA-dependent changes in mitochondrial membrane phospholipids play essential roles in the ability of LCA to extend yeast CLS.…”

Section: Some Mitochondrial Membrane Phospholipids Define Yeast Chronmentioning

confidence: 76%

Lipid metabolism and transport define longevity of the yeast Saccharomyces cerevisiae

et al. 2018

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Emergent evidence indicates that certain aspects of lipid synthesis, degradation and interorganellar transport play essential roles in modulating the pace of cellular aging in the budding yeast Saccharomyces cerevisiae. The molecular mechanisms underlying the vital roles of lipid metabolism and transport in defining yeast longevity have begun to emerge. The scope of this review is to critically analyze recent progress in understanding such mechanisms.

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Section: Some Mitochondrial Membrane Phospholipids Define Yeast Chronmentioning

confidence: 76%

Lipid metabolism and transport define longevity of the yeast Saccharomyces cerevisiae

et al. 2018

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“…In S. cerevisiae, mitochondrial dysfunctions affect the ability of a cell to deal with both replicative and chronological age (Fabrizio and Longo, 2003;Martinez et al, 2004;Trancíková et al, 2004;Bonawitz et al, 2006;Aerts et al, 2009;Ocampo et al, 2012;Beach et al, 2015). Proliferating yeast cells exhibit a dynamic network of mitochondrial tubules (Friedman and Nunnari, 2014).…”

Section: Mitochondriamentioning

confidence: 99%

The cell biology of quiescent yeast – a diversity of individual scenarios

Sagot

Laporte

2019

Journal of Cell Science

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Most cells, from unicellular to complex organisms, spend part of their life in quiescence, a temporary non-proliferating state. Although central for a variety of essential processes including tissue homeostasis, development and aging, quiescence is poorly understood. In fact, quiescence encompasses various cellular situations depending on the cell type and the environmental niche. Quiescent cell properties also evolve with time, adding another layer of complexity. Studying quiescence is, above all, limited by the fact that a quiescent cell can be recognized as such only after having proved that it is capable of re-proliferating. Recent cellular biology studies in yeast have reported the relocalization of hundreds of proteins and the reorganization of several cellular machineries upon proliferation cessation. These works have revealed that quiescent cells can display various properties, shedding light on a plethora of individual behaviors. The deciphering of the molecular mechanisms beyond these reorganizations, together with the understanding of their cellular functions, have begun to provide insights into the physiology of quiescent cells. In this Review, we discuss recent findings and emerging concepts in Saccharomyces cerevisiae quiescent cell biology.

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“…These organelles generate the majority of cellular ATP and create biosynthetic intermediates for amino acids, nucleotides and lipids [ 1 ]. Mitochondria can also operate as signaling platforms and structural scaffolds for coordinating diverse cellular responses to changes in a variety of physiological conditions [ 2 , 3 ]. Therefore, the functional state of mitochondria is crucial for a plethora of cellular processes, including cell growth, division, differentiation, homeostasis, metabolism, stress response, signaling, immune response, survival and death [ 1 - 4 ].…”

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confidence: 99%