Mechanisms and manifestations in musculoskeletal pain: from experimental to clinical pain settings

Graven‐Nielsen, Thomas

doi:10.1097/j.pain.0000000000002690

Cited by 10 publications

(7 citation statements)

References 268 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The procedure was repeated three times, and the mean value was calculated. Pressure algometry is used to induce deep tissue pain and measure mechanical pain sensitivity (20). Lower values indicated a lower threshold and higher sensitivity.…”

Section: Potential Prognostic Factorsmentioning

confidence: 99%

Transitioning to Barefoot Running Using a Minimalist Shoe Intermediary: A Prospective Cohort Study

Mills

Collins

Vicenzino

2022

Medicine &Amp; Science in Sports &Amp; Exercise

View full text Add to dashboard Cite

ObjectivesThe objectives of this study are, first, to investigate the probability of runners successfully transitioning from running in a traditional shoe to barefoot. Second, to identify prognostic indicators of failure of transition to barefoot running.MethodsOver 20 wk, 76 healthy runners (female, 40; age, 35.04 yr [SD, 8.9 yr]; body weight, 69.9 kg [SD 13.4 kg]) attempted to transition from running in traditional shoes to running barefoot. A minimalist shoe was used as an intermediary. Participants ran for 4 wk exclusively in provided traditional shoes followed by 4 wk of transitioning to minimalist shoes. This process was repeated to transition to barefoot running. Participants were followed up until they withdrew from the study or successfully transitioned to running barefoot. A survival analysis examined the weeks of successful transition. Along with sex and age, baseline measures of traditional shoe overall comfort, footstrike pattern, midfoot width mobility and plantar foot pressure pain threshold were examined as prognostic variables for failure to transition using Cox regression.ResultsThe cumulative probability of successful transition to running barefoot was 70.8% (95% confidence interval [CI], 61%–83%). The primary footwear-related reason for withdrawal was pain, primarily in the foot (n = 7), two runners had confirmed injuries. Runners exhibiting a rearfoot strike pattern and higher midfoot width mobility were more likely to fail to transition (hazard ratios [HR], 4.02; 95% CI, 1.33–12.16 and HR, 1.22; 95% CI, 1.05–1.42).ConclusionsMost runners who wish to run barefoot will be able to transition. Our study indicates that there may be biomechanical and anatomical characteristics that are prognostic of failing to transition when using a 20-wk transition period and an intermediary minimalist shoe. Whether a different transition process increases the probability of a success remains to be seen.

show abstract

Section: Potential Prognostic Factorsmentioning

confidence: 99%

Transitioning to Barefoot Running Using a Minimalist Shoe Intermediary: A Prospective Cohort Study

Mills

Collins

Vicenzino

2022

Medicine &Amp; Science in Sports &Amp; Exercise

View full text Add to dashboard Cite

show abstract

“…Musculoskeletal disorders(MSD) encompass a range of disorders affecting the bones, muscles, joints, and connective tissues, presenting a multifaceted challenge to individuals across various life stages. 2 However, the specific impact of these conditions on breastfeeding mothers (BFM) has garnered increasing attention due to the unique physiological changes they undergo during pregnancy and postpartum. 1 This paper delves into the intricate interplay between musculoskeletal health and BF, aiming to shed light on the prevalence, risk factors, and consequences of such conditions in this particular demographic.Studying MSD in BFM is essential for several reasons.…”

Section: Introductionmentioning

confidence: 99%

Impact of Targeted Exercises on the Musculoskeletal Disorders Experienced by Breastfeeding Mothers: A Pilot Study

Samiksha,

Jasmine,

Shikha

et al. 2024

IJSRR

View full text Add to dashboard Cite

show abstract

“…Altered pain sensitivity in a specific musculoskeletal region may indicate nociplastic pain,12 35 36 likely reflecting CS 13. Abundant studies have reported that a subgroup of patients with CLBP demonstrate segmental mechanical hyperalgesia, assessed via lower pressure pain thresholds (PPTs) in low back or lower extremity areas, when compared with healthy controls 37–42.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of chiropractic spinal manipulative therapy for patients with chronic primary low back pain: protocol for a mechanistic randomised placebo-controlled trial

2023

View full text Add to dashboard Cite

IntroductionChronic low back pain (CLBP) is a highly prevalent and disabling condition. Identifying subgroups of patients afflicted with CLBP is a current research priority, for which a classification system based on pain mechanisms was proposed. Spinal manipulative therapy (SMT) is recommended for the management of CLBP. Yet, little data are available regarding its mechanisms of action, making it difficult to match this intervention to the patients who may benefit the most. It was suggested that SMT may influence mechanisms associated with central sensitisation. Therefore, classifying patients with CLBP according to central sensitisation mechanisms may help predict their response to SMT.Methods and analysisThis protocol describes a randomised placebo-controlled trial aiming to examine which variables linked to central sensitisation may help predict the clinical response to SMT in a cohort of patients with CLBP. One hundred patients with chronic primary low back pain will be randomised to receive 12 sessions of SMT or placebo SMT over a 4-week period. Pain intensity and disability will be assessed as primary outcomes after completing the 4-week treatment (primary endpoint), and at 4-week and 12-week follow-ups. Baseline values of two pain questionnaires, lumbar pressure pain thresholds, concentrations of an inflammatory cytokine and expectations of pain relief will be entered as predictors of the response to SMT in a multiple regression model. Changes in these variables after treatment will be used in a second multiple regression model. The reference values of these predictors will be measured from 50 age and sex-matched healthy controls to allow interpretation of values in patients. Mixed analyses of variance will also be conducted to compare the primary outcomes and the predictors between groups (SMT vs placebo) over time (baseline vs post-treatment).Ethics and disseminationEthical approval was granted by the Fundación Jiménez Díaz Clinical Research Ethics Committee.Trial registration numberNCT05162924.

show abstract

Mechanisms and manifestations in musculoskeletal pain: from experimental to clinical pain settings

Cited by 10 publications

References 268 publications

Transitioning to Barefoot Running Using a Minimalist Shoe Intermediary: A Prospective Cohort Study

Transitioning to Barefoot Running Using a Minimalist Shoe Intermediary: A Prospective Cohort Study

Impact of Targeted Exercises on the Musculoskeletal Disorders Experienced by Breastfeeding Mothers: A Pilot Study

Mechanisms of chiropractic spinal manipulative therapy for patients with chronic primary low back pain: protocol for a mechanistic randomised placebo-controlled trial

Contact Info

Product

Resources

About