Mechanisms and implications of bone adipose tissue-mineral relationships

Elía, M.

doi:10.1038/ejcn.2012.88

Cited by 2 publications

(2 citation statements)

References 45 publications

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“…69 That relationship is called an inverse relationship between BMD and BMAT. 70,71 It is also worth considering that the intensity ratio of the methylene and methyl peaks should increase with increase of the mean length of the acyl chains. In our work, this ratio is slightly higher for R1 than for R30, and then from R30 it increases with animal age (Fig.…”

Section: Resultsmentioning

confidence: 99%

The solid-state proton NMR study of bone using a dipolar filter: apatite hydroxyl contentversusanimal age

2019

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Section: Resultsmentioning

confidence: 99%

The solid-state proton NMR study of bone using a dipolar filter: apatite hydroxyl contentversusanimal age

2019

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“…Once identified, observational studies began to report that BMAT is often inversely associated with bone mineral density (BMD). For example, this relationship has consistently been demonstrated during aging (Shen et al, 2014), post-menopausal osteoporosis (Shen et al, 2014), anorexia nervosa (Bredella et al, 2009), as well as during obesity (Elia, 2012;Rinonapoli et al, 2021;Ali et al, 2022). In these scenarios, patients often present with an increase in BMAT along with a decrease in bone mass or BMD (93).…”

Section: Adipose Tissuementioning

confidence: 96%

Endocrinal metabolic regulation on the skeletal system in post-menopausal women

2022

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Osteoporosis is a common endocrinologic disorder characterized as a chronic bone loss condition. Sexual dimorphism is ubiquitous in the incidence of osteoporosis with post-menopausal women being acutely affected. Gonadal sex hormones including estrogen act as crucial regulators of bone mass; therefore, loss of such hormones leads to an imbalance in skeletal turnover leading to osteoporosis. Estrogen can influence both bone formation as well as resorption by reducing osteoblast activity and enhancing osteoclastogenesis. Additionally, estrogen is a potent regulator of systemic metabolism. Recent studies have provided clues that estrogenic effect on bone might also involve alterations in bone cell metabolism and bioenergetic potential. While direct effects of gonadal hormones ability to alter intracellular metabolism of bone cells has not been studied, there is precedence within the literature that this is occurring and contributing to post-menopausal bone loss. This review aims to serve as a perspective piece detailing the prospective role of gonadal hormones regulating bone cell metabolic potential.

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Mechanisms and implications of bone adipose tissue-mineral relationships

Cited by 2 publications

References 45 publications

The solid-state proton NMR study of bone using a dipolar filter: apatite hydroxyl contentversusanimal age

The solid-state proton NMR study of bone using a dipolar filter: apatite hydroxyl contentversusanimal age

Endocrinal metabolic regulation on the skeletal system in post-menopausal women

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