Mechanism-oriented assessment of isotretinoin in chronic or subacute cutaneous lupus erythematosus

Newton, R. C.

doi:10.1001/archderm.122.2.170

Cited by 32 publications

(14 citation statements)

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“…The proposed mechanisms of retinoid action in the management of hypertrophic LE are speculative (13). They include inhibition of mononuclear cells, alteration of epidermal antigens and non immunologic direct effects on epidermal cell differentiation.…”

Section: Discussionmentioning

confidence: 99%

Hypertrophic Lupus Erythematosus Treated Successfully with Acitretin as Monotherapy

Al-Mutairi

Rijhwani

Nour-Eldin

2005

The Journal of Dermatology

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Hypertrophic lupus erythematosus (HLE) is a distinct and rare subset of chronic cutaneous lupus erythematosus characterized by verrucous lesions which are chronic in course and resistant to treatment (1). We describe the successful use of acitretin in a patient with HLE who had multiple hyperkeratotic verrucous plaques over the dorsa of his hands, feet, and legs and who failed to respond to local steroids and antimalarials.

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Section: Discussionmentioning

confidence: 99%

Hypertrophic Lupus Erythematosus Treated Successfully with Acitretin as Monotherapy

Al-Mutairi

Rijhwani

Nour-Eldin

2005

The Journal of Dermatology

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“…The relative contributions of the RA effect on tumor cells versus immune cells have yet to be determined. While RA promotes IL-2 and IL-2Rβ expression by T cells (Dennert, 1985; Ballow et al, 1997; Sidell et al, 1997), the positive effect of RA on anti-tumor immunity is at odds with the anti-inflammatory effect of RA and related RA analogs (retinoids) in the immune system (Newton et al, 1986). Retinoids ameliorate cutaneous inflammation caused by acne or lupus erythematosus.…”

Section: Ra Regulates T-cell Effector Functionmentioning

confidence: 99%

Host and Microbial Factors in Regulation of T Cells in the Intestine

Kim¹

2013

Front. Immunol.

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The intestine is divided into specialized tissue areas that provide distinct microenvironments for T cells. Regulation of T-cell responses in the gut has been a major focus of recent research activities in the field. T cells in the intestine are regulated by the interplay between host and microbial factors. In the small intestine, retinoic acid (RA) is a major tissue factor that plays important roles in regulation of immune responses. In the large intestine, the influence of RA diminishes, but that of commensal bacterial products increases. RA, gut microbiota, and inflammatory mediators co-regulate differentiation, distribution, and/or effector functions of T cells. Coordinated regulation of immune responses by these factors promotes well-balanced immunity and immune tolerance. Dysregulation of this process can increase infection and inflammatory diseases.

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“…41 Small studies and case series report benefit for retinoids, particularly in hypertrophic discoid lupus erythematosus (DLE); however, this form of lupus erythematosus is uncommon on the scalp. [42][43][44][45][46][47][48] A controlled but nonrandomized trial of high-dose hydroxychloroquine (n = 24) vs. placebo (n = 25) demonstrated hydroxychloroquine to be more effective than placebo; however, outcome measures were not clearly defined. 49 Jewell and McCauliffe 50 also demonstrated benefit, defined as complete or partial reduction in size or number of lesions, for antimalarials in CCLE and also noted that smokers were less likely to respond to treatment than nonsmokers.…”

Section: Second-line Treatment Antimalarials (Level Of Evidence = A) mentioning

confidence: 99%

Management of primary cicatricial alopecias: options for treatment

et al. 2008

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Primary cicatricial alopecias (PCAs) are a poorly understood group of disorders that result in permanent hair loss. Clinically, they are characterized not only by permanent loss of hair shafts but also of visible follicular ostia along with other visible changes in skin surface morphology, while their histopathological hallmark usually (although not always) is the replacement of follicular structures with scar-like fibrous tissue. As hair follicle neogenesis in adult human scalp skin is not yet a readily available treatment option for patients with cicatricial alopecias, the aim of treatment, currently, remains to reduce symptoms and to slow or stop PCA progression, namely the scarring process. Early treatment is the key to minimizing the extent of permanent alopecia. However, inconsistent terminology, poorly defined clinical end-points and a lack of good quality clinical trials have long made management of these conditions very challenging. As one important step towards improving the management of this under-investigated and under-serviced group of dermatoses, the current review presents evidence-based guidance for treatment, with identification of the strength of evidence, and a brief overview of clinical features of each condition. Wherever only insufficient evidence-based advice on PCA management can be given at present, this is indicated so as to highlight important gaps in our clinical knowledge that call for concerted efforts to close these in the near future.

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Mechanism-oriented assessment of isotretinoin in chronic or subacute cutaneous lupus erythematosus

Cited by 32 publications

References 0 publications

Hypertrophic Lupus Erythematosus Treated Successfully with Acitretin as Monotherapy

Hypertrophic Lupus Erythematosus Treated Successfully with Acitretin as Monotherapy

Host and Microbial Factors in Regulation of T Cells in the Intestine

Management of primary cicatricial alopecias: options for treatment

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