Mechanism of metformin regulation in central nervous system: Progression and future perspectives

Cao, Guojian; Gong, Ting; Du, Yong; Wang, Yicun; Ge, Tongtong; Liu, Jingyu

doi:10.1016/j.biopha.2022.113686

Cited by 36 publications

(28 citation statements)

References 165 publications

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“…Thiazolidinediones (TZDs) enhance insulin sensitivity in skeletal muscle, liver, and adipose tissue and promote fat redistribution from liver and skeletal muscle to adipocytes [ 58 , 59 , 60 ]. Metformin, the most commonly prescribed drug for diabetes, may also increase insulin sensitivity in peripheral tissues during fasting [ 61 , 62 , 63 , 64 , 65 , 66 ]. One of the mechanisms thought to be behind the protective effect of phenolic compounds on the T2DM is that OLE may increase glucagon-like peptide-1 (GLP-1) secretion both in vivo and in vitro [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

Updated Organic Composition and Potential Therapeutic Properties of Different Varieties of Olive Leaves from Olea europaea

Melo

Oliveira

Chéu

et al. 2023

Plants

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Olea europaea L. folium merits further exploration of the potential of its substrates for therapeutic supplements. Quantitative and qualitative analyses were conducted on samples of Madural, Verdeal, and Cobrançosa elementary leaves and leaf sprouts (mamões) collected in the region of Valpaços, Portugal. Organic analysis assessed the moisture content, total carbohydrates, ash, protein, and fat contents, total phenolic content (TPC), vitamin E, and fatty acid (FA) profiles. Moisture content was determined through infrared hygrometry and TPC was determined by a spectrophotometric method. Concerning organic analysis, all leaf samples showed similar moisture content, though Cobrançosa’s leaf sprouts and Verdeal’s elementary leaves had slightly lower contents. Meanwhile, these cultivars also showed a higher TPC, α-tocopherol isomer, and fatty acid composition (FAC). FAC in all samples exhibited higher contents of PUFA and SFA than MUFA, with a predominance of linolenic and palmitic acids. Organic analyses of Cobrançosa’s leaf sprouts and Verdeal’s elementary leaf extracts allow for the prediction of adequate physiological properties regarding neuroinflammatory, neurobehavioral, metabolic, cardiovascular, osteo-degenerative, anti-ageing, pulmonary, and immunological defense disorders. These physiological changes observed in our preliminary in silico studies suggest an excellent nutraceutical, which should be borne in mind during severe pandemic situations.

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Section: Discussionmentioning

confidence: 99%

Updated Organic Composition and Potential Therapeutic Properties of Different Varieties of Olive Leaves from Olea europaea

Melo

Oliveira

Chéu

et al. 2023

Plants

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“…Its pharmacological effect includes inhibition of hepatic gluconeogenesis, by reducing the expression of various genes involved. Likewise, metformin inhibits mitochondrial glycerol-3-phosphate dehydrogenase ( Cao et al, 2022 ). In the present study, the synergistic antinociception of the α -Bisabolol-diclofenac combination was significantly blocked by metformin.…”

Section: Discussionmentioning

confidence: 99%

Synergistic interaction and activation of the opioid receptor-NO–cGMP–K+ channel pathway on peripheral antinociception induced by the α-Bisabolol-diclofenac combination

Ortiz

2023

Front. Pharmacol.

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Introduction: The local peripheral combination of analgesic drugs with herbal derivatives may have beneficial effects. Information on the action mechanism of these interactions between drugs is scarce. Therefore, the main of the present study was to determine the pharmacological interaction and action mechanism of the combination α-Bisabolol and diclofenac.Methods: Rats were injected in the dorsal surface of the right hind paw with 1% formalin. Rats received subcutaneous injections in the dorsal surface of paw of vehicles or increasing doses of α-Bisabolol, diclofenac or their combination before formalin injection into the paw. Antinociception of the α-Bisabolol + diclofenac combination was evaluated with and without the local treatment of naloxone, metformin, NG-nitro-L-arginine methyl ester (L-NAME), 1H- (1,2,4)-oxadiazolo (4,2-a) quinoxalin-1-one (ODQ), glibenclamide, glipizide, 4-aminopyridine, tetraethylammonium, apamin, or charybdotoxin.Results: α-Bisabolol, diclofenac or α-Bisabolol-diclofenac combinations produced significant antinociception in the rat (p < 0.05). The experimental effective dose (ED) value of 109.2 µg/paw was different significantly of the theoretical effective dose (ED) of 245.7 µg/paw (synergism). Blockers significantly reverted the antinociception produced by the synergistic combination of α-Bisabolol and diclofenac.Discussion: Data showed a synergism of the α-Bisabolol-diclofenac combination and the activation of the opioid receptor-Nitric Oxide–cyclic GMP–K+ channels pathway and a biguanide-dependent mechanism in order to produce the potentiation of its peripheral antinociception in the formalin test.

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“…MF reduces the risk of developing various oncological diseases [15,[19][20][21][22]. In addition, there is evidence of a positive effect of MF in fibrosis, including radiation-induced ones [23], some diseases of the reproductive system, such as polycystic ovaries [24,25], cardiovascular diseases [15,[19][20][21][22], neurodegenerative diseases [26,27], including those caused by radiation therapy [28], and hormonal disorders [29].…”

Section: Metformin As a Medical Remedy For Diseases Caused By Oxidati...mentioning

confidence: 99%

“…Pretreatment with MF in children receiving cranial IR promotes the restoration of neurogenesis, attenuates the microglial response, and improves the recovery of long‐term olfactory memory [28]. It should be noted that MF is good as a potential neuroprotector under irradiation because it is able to penetrate the blood–brain barrier [27], in contrast to amifostine [114]. Presumably, the radiosensitizing mechanism of MF is realized through disturbance of the redox balance in tumor cells and a decrease in the level of inflammatory mediators [14].…”

Section: Metformin In Cancer Therapymentioning

confidence: 99%

Metformin counters oxidative stress and mitigates adverse effects of radiation exposure: An overview

Karmanova

Chernikov

Usacheva

et al. 2023

Fundamemntal Clinical Pharma

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Metformin (1,1‐dimethylbiguanidine hydrochloride) (MF) is a drug that has long been in use for the treatment of type 2 diabetes mellitus and recently is coming into use in the radiation therapy of cancer and other conditions. Exposure to ionizing radiation disturbs the redox homeostasis of cells and causes damage to proteins, membranes, and mitochondria, destroying a number of biological processes. After irradiation, MF activates cellular antioxidant and repair systems by signaling to eliminate the harmful consequences of disruption of redox homeostasis. The use of MF in the treatment of the negative effects of irradiation has great potential in medical patients after radiotherapy and in victims of nuclear accidents or radiologic terrorism.

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Mechanism of metformin regulation in central nervous system: Progression and future perspectives

Cited by 36 publications

References 165 publications

Updated Organic Composition and Potential Therapeutic Properties of Different Varieties of Olive Leaves from Olea europaea

Updated Organic Composition and Potential Therapeutic Properties of Different Varieties of Olive Leaves from Olea europaea

Synergistic interaction and activation of the opioid receptor-NO–cGMP–K+ channel pathway on peripheral antinociception induced by the α-Bisabolol-diclofenac combination

Metformin counters oxidative stress and mitigates adverse effects of radiation exposure: An overview

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