Mechanism of herpes simplex virus type 2 suppression by propolis extracts

Nolkemper, Silke; Reichling, Jürgen; Sensch, Karl Heinz; Schnitzler, Paul

doi:10.1016/j.phymed.2009.07.006

Cited by 100 publications

(69 citation statements)

References 35 publications

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“…Chlorogenic acid and its related compounds are abundant plant polyphenols that have anti HSV-1 activity (Chiang et al, 2002;Wang et al, 2009;Nolkemper et al, 2010). In the same way, the anti-HSV activity of naturally occurring flavonoids has also been described (Lyu et al, 2005;Schnitzler et al, 2010).…”

Section: Antiviral Activitymentioning

confidence: 91%

Hepatoprotective effects and HSV-1 activity of the hydroethanolic extract ofCecropia glaziovii(embaúba-vermelha) against acyclovir-resistant strain

Petronilho¹,

Costa²,

Kappel³

et al. 2012

Pharmaceutical Biology

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Section: Antiviral Activitymentioning

confidence: 91%

Hepatoprotective effects and HSV-1 activity of the hydroethanolic extract ofCecropia glaziovii(embaúba-vermelha) against acyclovir-resistant strain

Petronilho¹,

Costa²,

Kappel³

et al. 2012

Pharmaceutical Biology

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“…Propolis has been extensively used in traditional medicine due to its several pharmacological and biological properties -antimicrobial, immunomodulatory, anti-inflammatory and antioxidant (Nakamura et al, 2010;Vatansever et al, 2010). The pharmacological activity of propolis against several viral infections has been evaluated in vitro with some viruses (Nolkemper et al, 2010) and it was found out that one of the important biological activities of the propolis was its antimicrobial activity. According to this fact, the use of propolis in BALB/c mice diets is significantly effective in different bacteria, viruses and fungi (Murad et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

The effect of different levels of propolis in diets on performance, gastrointestinal morphology and some blood parameters in broiler chickens

Shaddel-Tili¹,

Eshratkhan²,

Kouzehgari³

et al. 2017

BJVM

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SummaryShaddel-Tili, A., B. Eshratkhan, H. Kouzehgari & M. Ghasemi-Sadabadi, 2017. The effect of different levels of propolis in diets on performance, gastrointestinal morphology and some blood parameters in broiler chickens. Bulg. J. Vet. Med., 20, No 3,[215][216][217][218][219][220][221][222][223][224] A study was conducted to determine the effect of different levels of propolis in diets on performance, carcass characteristics, gastrointestinal morphology and some blood parameters in broiler chickens. A total of 224 one day-old Ross 308 chicks were randomly allocated to one of the 16 floor pens in a completely randomised design (four treatments, four replicate groups, 14 chicks in each group). Dietary treatments consisted of 4 different levels of propolis powder including zero (control), 500, 1500, 2000 ppm in the diet throughout the entire experimental period (42 days). The feed was offered ad libitum. All the chickens were grown up in the same environmental and management conditions. Body weight gain, food intake and feed conversion ratio were measured at the end of each period, also, the production index was calculated at 42 days of age. At the end of experimental period, two chicks from each pen were selected and after blood sample collection were slaughtered and dissected manually. Haematological and biochemical parameters as well as carcass characteristics, gastrointestinal morphology were determined. The use of 2000 parts per million propolis powder in diet improved body weight gain, feed intake, feed conversion ratio and production index at all experimental periods (P<0.05). High dietary levels of propolis powder in diets increased the relative weight of crop, thighs and length of gizzard compared to other treatments, and decreased the relative weight of livers of broiler chickens (P<0.05). PCV and heterophil counts were significantly increased (P<0.05). It is suggested that the supplementation of propolis powder to poultry diets had a positive effect on growth performance, carcass characteristics and blood parameters.

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“…Propolis has been used in folk medicines and complementary therapies since 3,000 BC in Egypt and has become one of the most popular functional foods all around the world. Propolis show a broad spectrum of bioactivities, such as antioxidant [6], antimicrobial [7], antitumor [8], antiviral [9], anti-ulcer [10], immunomodulatory [11], cardioprotective [12], and anti-inflammatory effects [13]. …”

Section: Introductionmentioning

confidence: 99%

Molecular Mechanisms Underlying theIn VitroAnti-Inflammatory Effects of a Flavonoid-Rich Ethanol Extract from Chinese Propolis (Poplar Type)

Wang

Ping

Huang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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China produces the greatest amount of propolis but there is still lack of basic studies on its pharmacological mechanisms. Our previous study found that ethanol extract from Chinese propolis (EECP) exerted excellent anti-inflammatory effects in vivo but mechanisms of action were elusive. To further clarify the possible mechanisms underlying the anti-inflammatory effects of Chinese propolis (poplar type), we utilized EECP to analyze its chemical composition and evaluated its potential anti-inflammatory effects in vitro. High-performance liquid chromatography (HPLC) profile indicated that EECP contained abundant flavonoids, including rutin, myricetin, quercetin, kaempferol, apigenin, pinocembrin, chrysin, and galangin. Next we found that EECP could significantly inhibit the production of NO, IL-1β, and IL-6 in lipopolysaccharide- (LPS-) stimulated RAW 264.7 cells and suppress mRNA expression of iNOS, IL-1β, and IL-6 in a time- and dose-dependent manner. Furthermore, we found that EECP could suppress the phosphorylation of IκBα and AP-1 but did not affect IκBα's degradation. In addition, using a reporter assay, we found that EECP could block the activation of NF-κB in TNF-α-stimulated HEK 293T cells. Our findings give new insights for understanding the mechanisms involved in the anti-inflammatory effects by Chinese propolis and provide additional references for using propolis in alternative and complementary therapies.

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Mechanism of herpes simplex virus type 2 suppression by propolis extracts

Cited by 100 publications

References 35 publications

Hepatoprotective effects and HSV-1 activity of the hydroethanolic extract ofCecropia glaziovii(embaúba-vermelha) against acyclovir-resistant strain

Hepatoprotective effects and HSV-1 activity of the hydroethanolic extract ofCecropia glaziovii(embaúba-vermelha) against acyclovir-resistant strain

The effect of different levels of propolis in diets on performance, gastrointestinal morphology and some blood parameters in broiler chickens

Molecular Mechanisms Underlying theIn VitroAnti-Inflammatory Effects of a Flavonoid-Rich Ethanol Extract from Chinese Propolis (Poplar Type)

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