1980
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Abstract: A B S T R A C T Although it is well established that bilirubin monoglucuronide is formed in the liver from bilirubin by a microsomal bilirubin uridine diphosphate (UDP)-glucuronosyltransferase, the subcellular site of conversion of monoglucuronide to diglucuronide and the molecular mechanism involved in diglucuronide synthesis have not been identified. Based on in vitro studies, it has been proposed that two fundamentally different enzyme systems may be involved in diglucuronide synthesis in rat liver: (a) a m… Show more

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Cited by 32 publications
(17 citation statements)
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References 31 publications
(53 reference statements)
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“…(Fig. 1) and patients (33) with cholestatic jaundice and for the apparent deconjugation of bilirubin glucuronides detected in experimental studies (32, 34,35).…”
Section: Resultsmentioning
confidence: 88%
“…(Fig. 1) and patients (33) with cholestatic jaundice and for the apparent deconjugation of bilirubin glucuronides detected in experimental studies (32, 34,35).…”
Section: Resultsmentioning
confidence: 88%
“…Third, estimation of the apparent volume of distribution of the plasma conjugated bilirubin compartment (P,) yielded an improbably high value of 166 ml (Table II). Fourth, bilirubin glucuronides added to plasma in vitro do not undergo hydrolysis (31). Thus, to resolve this apparent discrepancy in the model, a location for bilirubin deconjugation was sought which is adjacent to the plasma compartment permitting rapid equilibration with it.…”
Section: Discussionmentioning
confidence: 99%
“…It was first suggested by the observation in Gunn rats that intravenous injection of normal rat bile containing conjugated bilirubin led to an increase in the plasma unconjugated pigment level (54,55). More recently, it was found that infusion of BDG into Gunn rats resulted in biliary excretion ofabout 6% BMG (31). Moreover, in normal rats infused with BMG dual-labeled in the glucuronosyl and tetrapyrrole moieties, recovery in bile of the label contained in the glucuronosyl group consistently was less than that in the tetrapyrrole moiety (31).…”
Section: Discussionmentioning
confidence: 99%
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“…However, the route by which the monoglucuronide is transformed into the diglucuronide has been the subject of recent controversy. One proposal (Blanckaert et al, 1979) suggests that the diglucuronide is formed in a sequential process involving the enzymic transfer of a glucuronosyl residue from UDP-glucuronic acid to the free propionic acid group of bilirubin monoglucuronide. An alternative proposal (Jansen et al, 1977;Chowdhury et al, 1979) suggests that an enzyme-catalysed disproportionation of bilirubin monoglucuronide occurs and that two molecules of the monoglucuronide give rise to one molecule of unconjugated bilirubin and one molecule of the diglucuronide.…”
mentioning
confidence: 99%