volume 93, issue 0, P2-P-159 2020
DOI: 10.1254/jpssuppl.93.0_2-p-159
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Abstract: The unilateral peripheral injury or inflammation produces in bilateral hypersensitivity to pain in the ipsilateral and contralateral sides. This phenomenon is reported in clinical pain syndromes and in various animal pain models. However, its mechanism is not cleared. In the present study, we investigated the mechanism of this phenomenon using the inflammatory pain model and the capsaicin test. Chronic inflammatory pain was induced by injecting the complete Freund's adjuvant (CFA) and assessed the mechanical a…

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