Mechanical Vibration Measurement of Solidly Mounted Resonator in Fluid by Atomic Force Microscopy

Xu, Fei; Guo, Xinyi; Duan, Xuexin; Zhang, Hao; Fu, Xing

doi:10.3390/mi8080244

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…The resonator vibration and fluid force distribution along the resonator surface were characterized by AFM (Dimension Icon, Bruker Corp., Bremen, Germany), which were performed following the procedures described in previous publication. [ 48 ] Briefly, the gigahertz resonator was actuated by an amplitude‐modulated signal during AFM detection. The carrier frequency was equal to the resonance frequency, and the modulation frequency was equal to the second resonance frequency (≈110 kHz) of the AFM cantilever.…”

Section: Methodsmentioning

confidence: 99%

Controllable Cell Deformation Using Acoustic Streaming for Membrane Permeability Modulation

et al. 2020

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Hydrodynamic force loading platforms for controllable cell mechanical deformation play an essential role in modern cell technologies. Current systems require assistance from specific microstructures thus limiting the controllability and flexibility in cell shape modulation, and studies on real‐time 3D cell morphology analysis are still absent. This article presents a novel platform based on acoustic streaming generated from a gigahertz device for cell shape control and real‐time cell deformation analysis. Details in cell deformation and the restoration process are thoroughly studied on the platform, and cell behavior control at the microscale is successfully achieved by tuning the treating time, intensity, and wave form of the streaming. The application of this platform in cell membrane permeability modulation and analysis is also exploited. Based on the membrane reorganization during cell deformation, the effects of deformation extent and deformation patterns on membrane permeability to micro‐ and macromolecules are revealed. This technology has shown its unique superiorities in cell mechanical manipulation such as high flexibility, high accuracy, and pure fluid force operation, indicating its promising prospect as a reliable tool for cell property study and drug therapy development.

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Section: Methodsmentioning

confidence: 99%

Controllable Cell Deformation Using Acoustic Streaming for Membrane Permeability Modulation

et al. 2020

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“…A key factor in the realization of FM-AFM technology is the detection of frequency. Several methods can be used to detect the vibration frequency of the probe, such as digital or analog frequency demodulation methods and lock-in amplifier (LIA) methods [ 23 , 24 , 25 ]. As early as 1991, Albrecht et al used an analog phase demodulator to detect the frequency of the high-Q-value probe in FM-AFM [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Measurement and Control System for Atomic Force Microscope Based on Quartz Tuning Fork Self-Induction Probe

et al. 2023

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In this paper, we introduce a low-cost, expansible, and compatible measurement and control system for atomic force microscopes (AFM) based on a quartz tuning fork (QTF) self-sensing probe and frequency modulation, which is mainly composed of an embedded control system and a probe system. The embedded control system is based on a dual-core OMAPL138 microprocessor (DSP + ARM) equipped with 16 channels of a 16-bit high-precision general analog-to-digital converter (ADC) and a 16-bit high-precision general digital-to-analog converter (DAC), six channels of an analog-to-digital converter with a second-order anti-aliasing filter, four channels of a direct digital frequency synthesizer (DDS), a digital input and output (DIO) interface, and other peripherals. The uniqueness of the system hardware lies in the design of a high-precision and low-noise digital—analog hybrid lock-in amplifier (LIA), which is used to detect and track the frequency and phase of the QTF probe response signal. In terms of the system software, a software difference frequency detection method based on a digital signal processor (DSP) is implemented to detect the frequency change caused by the force gradient between the tip and the sample, and the relative error of frequency measurement is less than 3%. For the probe system, a self-sensing probe controller, including an automatic gain control (AGC) self-excitation circuit, is designed for a homemade balanced QTF self-sensing probe with a high quality factor (Q value) in an atmospheric environment. We measured the quality factor (Q value) of the balanced QTF self-sensing probes with different lengths of tungsten tips and successfully realized AFM topography imaging with a tungsten-tip QTF probe 3 mm in length. The results show that the QTF-based self-sensing probe and the developed AFM measurement and control system can obtain high quality surface topography scanning images in an atmospheric environment.

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Periodic solutions of a tapping mode cantilever in an Atomic Force Microscope with harmonic excitation

Zapata

Gutierrez

Duque³

2022

Communications in Nonlinear Science and Numerical Simulation

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Mechanical Vibration Measurement of Solidly Mounted Resonator in Fluid by Atomic Force Microscopy

Cited by 3 publications

References 20 publications

Controllable Cell Deformation Using Acoustic Streaming for Membrane Permeability Modulation

Controllable Cell Deformation Using Acoustic Streaming for Membrane Permeability Modulation

Measurement and Control System for Atomic Force Microscope Based on Quartz Tuning Fork Self-Induction Probe

Periodic solutions of a tapping mode cantilever in an Atomic Force Microscope with harmonic excitation

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