Mechanical stimulation improves rotator cuff tendon-bone healing via activating IL-4/JAK/STAT signaling pathway mediated macrophage M2 polarization

Liu, Yuqian; Wang, Linfeng; Li, Shengcan; Zhang, Tao; Chen, Can; Hu, Jianzhong; Sun, Dong; Lu, Hongbin

doi:10.1016/j.jot.2022.08.008

Cited by 29 publications

(19 citation statements)

References 41 publications

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“…Similarly, Natalie A Sims also held the same views and believed that the JAK1/STAT3/SOCS3 axis featured in bone development, physiology and pathology (Sims, 2020). Meanwhile, recent studies have shown that mechanical stimulation improves rotator cuff tendon-bone healing by activating IL-4/JAK/STAT signaling pathway mediated macrophage-M2 polarization (Liu et al, 2022). All in all, these studies indicate that JAK/STAT pathway plays an important role in bone development and repair.…”

Section: Biophysical Forces In Regulating the Jak/ Stat Pathwaymentioning

confidence: 85%

JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens

Bian

Rong

et al. 2023

Front. Bioeng. Biotechnol.

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Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were originally thought to be intracellular signaling pathways that mediate cytokine signals in mammals. Existing studies show that the JAK/STAT pathway regulates the downstream signaling of numerous membrane proteins such as such as G-protein-associated receptors, integrins and so on. Mounting evidence shows that the JAK/STAT pathways play an important role in human disease pathology and pharmacological mechanism. The JAK/STAT pathways are related to aspects of all aspects of the immune system function, such as fighting infection, maintaining immune tolerance, strengthening barrier function, and cancer prevention, which are all important factors involved in immune response. In addition, the JAK/STAT pathways play an important role in extracellular mechanistic signaling and might be an important mediator of mechanistic signals that influence disease progression, immune environment. Therefore, it is important to understand the mechanism of the JAK/STAT pathways, which provides ideas for us to design more drugs targeting diseases based on the JAK/STAT pathway. In this review, we discuss the role of the JAK/STAT pathway in mechanistic signaling, disease progression, immune environment, and therapeutic targets.

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Section: Biophysical Forces In Regulating the Jak/ Stat Pathwaymentioning

confidence: 85%

JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens

Bian

Rong

et al. 2023

Front. Bioeng. Biotechnol.

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“…Mice were allowed for free cage activities after surgery (FC group); Mice received treadmill running initiated on postoperative day 7 (TR group); In comparision to FC group, TR group showed better fibrocartilage regeneration which was characterized by more cartilage-like cells and richer proteoglycans accumulation at repaired site at postoperative week 4 and 8. Reproduced with permission (Liu et al, 2022).…”

Section: Figurementioning

confidence: 99%

“…This shows that the timing of the start of exercise is very important and needs to be further defined. Running exercise has also been shown to significantly increase IL-4 production, activation of the macrophage JAK/STAT signaling pathway, macrophage polarization, and the quality of tendon bone healing (Liu et al, 2022) Figure 2F. Although all of these treatment options are effective to a certain extent, there are some limitations.…”

Section: Other Stimulationmentioning

confidence: 99%

External stimulation: A potential therapeutic strategy for tendon-bone healing

Lan

Wang

et al. 2023

Front. Bioeng. Biotechnol.

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Injuries at the tendon-bone interface are very common in the field of sports medicine, and healing at the tendon-bone interface is complex. Injuries to the tendon-bone interface can seriously affect a patient’s quality of life, so it is essential to restore stability and promote healing of the tendon-bone interface. In addition to surgical treatment, the healing of tendons and bones can also be properly combined with extracorporeal stimulation therapy during the recovery process. In this review, we discuss the effects of extracorporeal shock waves (ESWs), low-intensity pulsed ultrasound (LIPUS), and mechanical stress on tendon-bone healing, focusing on the possible mechanisms of action of mechanical stress on tendon-bone healing in terms of transcription factors and biomolecules. The aim is to provide possible therapeutic approaches for subsequent clinical treatment.

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“…Accurate simulation of biological microstructure is important for specifically inducing injured tissue reconstruction. In fact, the TBI is a transition structure from the soft tissue to hard tissue, which can be stratified into the bone tissue, mineralized fibrocartilage, nonmineralized fibrocartilage, and tendon tissue. − From the tendon to the bone, the collagen fiber gradually decreases, whereas mineral content gradually increases, thus forming a unique transition zone, which helps to uniformly transfer stress from the soft tissue to hard tissue and avoid stress concentration. , Therefore, we designed a gradient polar scaffold mimicking the transition structure of the TBI to enhance the mechanical properties of the tissue after the rotator cuff injury, while improving the inherent healing potential, thus improving the success rate of the repair of rotator cuff injury, which might be a potential tendon-bone repair strategy.…”

Section: Introductionmentioning

confidence: 99%

Gradient Bipolar Nanofiber Scaffolds with a Structure of Biomimetic Tendon-Bone Interface as Rotator Cuff Patches

Shang

et al. 2023

ACS Appl. Polym. Mater.

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Due to the special three-dimensional gradient structure from the bone to tendon at the tendon-bone interface (TBI), it is difficult to achieve a good therapeutic effect after rotator cuff injury. Biomimetic tissue-engineered gradient biphasic fiber patches may be a potential scaffold for repair. In this study, a gradient bipolar nanofiber scaffold with a structure of biomimetic TBI (SPGM) was prepared by continuous layer-by-layer electrospinning using poly(glycolide-co-ε-caprolactone), silk fibroin, and mesoporous bioactive glasses. The physicochemical characterization and mechanical test results confirmed that the SPGM could effectively avoid the stress concentration caused by easy to aggregate components and exhibited significantly matched mechanical properties. Moreover, SPGM also exhibited higher porosity, larger specific surface area, and suitable pore size for the growth of host cells. Cytocompatibility experiments, immunofluorescence staining, and cell morphology further demonstrated that the bipolar structure of gradient patches could induce rapid proliferation and adhesion of fibroblasts and osteoblasts, respectively. Therefore, this gradient bipolar nanofiber scaffold maybe a reliable candidate for rotator cuff repair.

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Mechanical stimulation improves rotator cuff tendon-bone healing via activating IL-4/JAK/STAT signaling pathway mediated macrophage M2 polarization

Cited by 29 publications

References 41 publications

JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens

JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens

External stimulation: A potential therapeutic strategy for tendon-bone healing

Gradient Bipolar Nanofiber Scaffolds with a Structure of Biomimetic Tendon-Bone Interface as Rotator Cuff Patches

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