Mechanical properties, in vitro and in vivo biocompatibility analysis of pure iron porous implant produced by metal injection molding: A new eco-friendly feedstock from natural rubber (Hevea brasiliensis)

Wermuth, Diego Pacheco; Paim, Thaís Casagrande; Bertaco, Isadora; Zanatelli, Carla; Naasani, Liliana Ivet Sous; Slaviero, Mônica; Driemeier, David; Tavares, André; Martins, Vinícius; Escobar, Camila Ferreira; Santos, Luís Alberto Loureiro dos; Schaeffer, Lírio; Wink, Márcia Rosângela

doi:10.1016/j.msec.2021.112532

Cited by 11 publications

(5 citation statements)

References 48 publications

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“…A subcutaneous implant model in rats was used to evaluate the biodegradability of the CDOM‐EDTA film. [ 31 ] In the first four weeks after surgery, the CDOM‐EDTA films gradually decomposed, reaching a complete breakdown in the sixth week (Figure S17, Supporting Information). Due to its biodegradable nature, we believe our CDOM‐EDTA film might contribute to a reduction in the sensation of foreign bodies following surgery.…”

Section: Resultsmentioning

confidence: 99%

Cuttlebone‐Derived Organic Matrix: A Facile Periosteum Substitute for Bone Regeneration

Wei

Zheng

et al. 2023

Adv Funct Materials

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Artificial periosteum has become a novel strategy for bone healing. Several efforts are made to develop novel periosteum substitutes with excellent osteogenesis and angiogenesis performance. The problem, however, is that many inconveniences, such as unattainable materials and complex preparation processes, limit its clinical application. In this study, cuttlebone-derived organic matrix (CDOM) film is developed as a facile obtained artificial periosteum with good bioactivity, biodegradability, and biosafety. In this study, CDOM films are prepared by etching calcium carbonate of cuttlebone with hydrochloric acid (HCl), phosphoric acid (H 3 PO 4 ), and ethylenediaminetetraacetic acid (EDTA), respectively. CDOM films possess "S" oriented grooves on one surface, providing suitable space for survival, adhesion, and proliferation of rat mesenchymal stem cells and human umbilical vein endothelial cells. Among three CDOM films, CDOM-EDTA is the most efficient at enhancing bone regeneration in vivo, with an increase in neovascularization and new bone formation. Meanwhile, CDOM-EDTA is degradable in two months and of extremely low toxicity. There is a great deal of promise in the future for this novel periosteum substitute to be used for bone defect healing in clinical settings.

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Section: Resultsmentioning

confidence: 99%

Cuttlebone‐Derived Organic Matrix: A Facile Periosteum Substitute for Bone Regeneration

Wei

Zheng

et al. 2023

Adv Funct Materials

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“…( Fig. 8 ) [ 36 , 72 , 74 ]. Others parameters as morphology, reactive oxygen species (ROS) production [ 29 ], gene expression [ 75 ] and cell proliferation are also evaluated.…”

Section: Biosafety Of Fe-based Stentmentioning

confidence: 99%

“…There is a consensus regarding the absence of toxicity of the soluble iron degradation products on several types of cells as fibroblasts [ 48 , [75] , [76] , [77] ], CHO–K1 [ 71 ], human endothelial cells [ 38 , 72 ], smooth muscle cells [ 35 , 36 ] and ADSCs ( Fig. 8 b) [ 74 ]. These studies showed that the cellular metabolic activity was not affected by the presence of soluble degradation products after 24–72 h. However, a reduction in cell proliferation was reported on smooth muscle cells, which was considered as a positive point, since these cells are the main responsible for in-stent restenosis [ 35 , 78 ].…”

Section: Biosafety Of Fe-based Stentmentioning

confidence: 99%

Recent advances in Fe-based bioresorbable stents: Materials design and biosafety

Zhang,

Roux,

Rouchaud

et al. 2024

Bioactive Materials

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“…Metal injection molding (MIM), a type of PIM, has made inroads into numerous industries as it is fast, cost effective, versatile, and potentially downsizable, as well as possessing outstanding design, dimensional accuracy, and mechanical properties that yield an exceptional surface finish and minimal by-products or waste [39][40][41][42][43][44][45][46][47][48]. At present, MIM is a popular method of manufacturing precise net-shaped parts for orthopedic and dental implants, surgical tools, and medical equipment [21,[49][50][51][52][53][54][55]. Figure 1 depicts some commonly used MIM-fabricated medical tools and equipment.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Processing of Titanium and Titanium Alloys through Metal Injection Molding for Biomedical Applications: 2013–2022

et al. 2023

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Metal injection molding (MIM) is one of the most widely used manufacturing processes worldwide as it is a cost-effective way of producing a variety of dental and orthopedic implants, surgical instruments, and other important biomedical products. Titanium (Ti) and Ti alloys are popular modern metallic materials that have revamped the biomedical sector as they have superior biocompatibility, excellent corrosion resistance, and high static and fatigue strength. This paper systematically reviews the MIM process parameters that extant studies have used to produce Ti and Ti alloy components between 2013 and 2022 for the medical industry. Moreover, the effect of sintering temperature on the mechanical properties of the MIM-processed sintered components has been reviewed and discussed. It is concluded that by appropriately selecting and implementing the processing parameters at different stages of the MIM process, defect-free Ti and Ti alloy-based biomedical components can be produced. Therefore, this present study could greatly benefit future studies that examine using MIM to develop products for biomedical applications.

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Mechanical properties, in vitro and in vivo biocompatibility analysis of pure iron porous implant produced by metal injection molding: A new eco-friendly feedstock from natural rubber (Hevea brasiliensis)

Cited by 11 publications

References 48 publications

Cuttlebone‐Derived Organic Matrix: A Facile Periosteum Substitute for Bone Regeneration

Cuttlebone‐Derived Organic Matrix: A Facile Periosteum Substitute for Bone Regeneration

Recent advances in Fe-based bioresorbable stents: Materials design and biosafety

Recent Advances in Processing of Titanium and Titanium Alloys through Metal Injection Molding for Biomedical Applications: 2013–2022

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