Mechanical properties and biochemical activity of remineralizing resin-based Ca–PO4 cements

Dickens, Sabine H.; Flaim, Glenn M.; Takagi, Shōzō

doi:10.1016/s0109-5641(02)00105-7

Cited by 184 publications

(314 citation statements)

References 13 publications

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“…A 3 × 2 full factorial design was used with two levels of whisker reinforcement (DCPA:whisker mass ratio = 1:0 or no whiskers; DCPA:whisker = 1:1), and three levels of DCPA particle size (112 nm, 0.88 μm, 12.0 μm). The DCPA powders were not silanized so that the Ca and PO 4 release would not be inhibited, following previous studies on calcium phosphate composites [19,21,32]. The nano-silica-fused whiskers were silanized to provide maximum reinforcement.…”

Section: Resin Composite Fabricationmentioning

confidence: 99%

“…This compared to a specimen volume per solution of approximately 3.0 mm 3 /mL in a previous study [19]. The concentrations of Ca and PO 4 released from the specimens were measured vs. [19,21]. The standard uncertainty for the Ca and PO 4 release measurements was estimated to be 3 % [36].…”

Section: Ca and Po 4 Releasementioning

confidence: 99%

“…Hence there is a wide range of solution conditions when the precipitation of hydroxyapatite occurs spontaneously. Indeed, several bioactive composites have been developed that release calcium and phosphate ions in the presence of an aqueous solution, which then precipitate to form hydroxyapatite [18][19][20][21]. The calcium ions are conveniently referred to as Ca, and the phosphate ions as PO 4 , following previous studies [20,21].…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies on calcium phosphate composites used single particle sizes (e.g., a particle size of 1.1 μm for dicalcium phosphate anhydrous [CaHPO 4 ], or DCPA) [21], without varying the particle size and examining this effect. Previous studies used unsilanized calcium phosphate fillers, without investigating whether the silane would improve the composite mechanical properties or retard the release of Ca and PO 4 ions.…”

Section: Introductionmentioning

confidence: 99%

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Nanocomposites with Ca and PO4 release: Effects of reinforcement, dicalcium phosphate particle size and silanization☆

2007

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Objectives-Nano-particles of dicalcium phosphate anhydrous (DCPA) were synthesized in our laboratory for the first time and incorporated into a dental resin. Our goal was to develop a mechanically strong dental composite that has Ca and PO 4 ion release to combat tooth caries, and to investigate the effects of whisker reinforcement, DCPA particle size and silanization.Methods-DCPA nano-particles and two larger DCPA particles were used with nano-silica-fused whiskers as fillers in a resin matrix. Composite mechanical properties were measured via three-point flexure, and the release of Ca and PO 4 ions were measured vs. time.Results-Using DCPA nano-particles with a diameter of 112 nm, the composite at a DCPA:whisker mass ratio of 1:1 had a flexural strength (mean ± sd; n = 5) of (112 ± 17) MPa, not significantly different from (112 ± 14) MPa of a commercial non-releasing composite; both were higher than (29 ± 7) MPa for the composite at DCPA:whisker of 1:0 (p < 0.05). The composite with DCPA particle size of 112 nm released Ca to a concentration of 0.85 mmol/L and PO 4 of 3.48 mmol/L, higher than Ca of 0.67 mmol/L and PO 4 of 1.11 mmol/L using DCPA with 12 μm particle size (p < 0.05). Silanization of DCPA increased the composite strength at DCPA:whisker of 1:0 compared to that without silanization, but decreased the Ca and PO 4 release (p < 0.05). Increasing the DCPA particle surface area increased the Ca and PO 4 release.Significance-Decreasing the DCPA particle size increased the Ca and PO 4 release; whisker reinforcement increased the composite strength by 2 to 3 fold. The nano DCPA-whisker composites, with high strength and Ca and PO 4 release, may provide the needed, unique combination of stressbearing and caries-inhibiting capabilities.

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Section: Resin Composite Fabricationmentioning

confidence: 99%

Section: Ca and Po 4 Releasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nanocomposites with Ca and PO4 release: Effects of reinforcement, dicalcium phosphate particle size and silanization☆

2007

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“…Recently, direct application of HAp nanoparticles to repair damaged enamel has attracted attention because of its dissolvability (i.e., the remineralization effect due to the release of calcium and phosphate ions 46,47) and a neutralization effect 48) ). The HAp nanoparticles with controlled CPC release profiles developed in this study show potential applications as enamel repair agents to restore the damaged enamel and prevent the formation of secondary caries.…”

Section: Discussionmentioning

confidence: 99%

Adsorption and desorption behaviors of cetylpyridinium chloride on hydroxyapatite nanoparticles with different morphologies

et al. 2016

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Application of hydroxyapatite (HAp) nanoparticles to repair damaged enamel has attracted recent attention. In this study, HAp nanoparticles with various morphologies (spherical, short-rod, long-rod and fiber morphologies) were synthesized via chemical precipitation methods without the addition of template molecules, and the adsorption/desorption behaviors of a cationic antibacterial agent, cetylpyridinium chloride (CPC), on the HAp nanoparticles were evaluated. The adsorption of CPC on each HAp nanoparticle showed Langmuir-type adsorption, and the short-rod/long-rod HAp nanoparticles showed thermodynamically more stable adsorption of CPC than that with the spherical/fiber HAp nanoparticles. The desorption rate of CPC from the short-rod/long-rod HAp nanoparticles was slower than that of the spherical/fiber HAp nanoparticles. The HAp nanoparticles with different CPC release profiles presented here have potential applications as nanoparticulate enamel repair agents with antibacterial properties.

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Bioactive and Biocompatible Polymeric Composites Based on Amorphous Calcium Phosphate

Antonucci

Škrtić²

2012

Integrated Biomaterials for Biomedical Technology

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Mechanical properties and biochemical activity of remineralizing resin-based Ca–PO4 cements

Cited by 184 publications

References 13 publications

Nanocomposites with Ca and PO4 release: Effects of reinforcement, dicalcium phosphate particle size and silanization☆

Nanocomposites with Ca and PO4 release: Effects of reinforcement, dicalcium phosphate particle size and silanization☆

Adsorption and desorption behaviors of cetylpyridinium chloride on hydroxyapatite nanoparticles with different morphologies

Bioactive and Biocompatible Polymeric Composites Based on Amorphous Calcium Phosphate

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