Mechanical, Optical and Antibacterial Properties of Polylactic Acid/Polyethylene Glycol Films Reinforced with MgO Nanoparticles

Swaroop, Chetan; Shukla, Mukul

doi:10.1016/j.matpr.2018.06.455

Cited by 20 publications

(21 citation statements)

References 15 publications

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“…It has been reported that, incorporation of magnesium oxide nanoparticles into PLA/PEG film enhanced antibacterial efficacy of the film. However, in comparison to our study, less than 50% bactericidal activity has been reported after 24 h of treatment 34 . Moreover, chemically synthesized Ag nanoparticles deposition was also reported by Turalija et al to enhance antibacterial property of PEG/PLA films 35 , but a slightly lower antibacterial efficacy against S.aureus has been observed compared to our study.…”

Section: Morphology Of Agnps Containing Nanofilmscontrasting

confidence: 99%

“…Barbosa et al demonstrated that the addition of terpinen-4-ol to PLA/PEG reduces the viable Aggregatibacter actinomycetemcomita cells of biofilm 33 . Another study indicated that the incorporation of magnesium oxide nanoparticles into PLA/PEG enhances the antibacterial efficacy of the film 34 . Turalija et al used plasma technology to silver nanoparticles deposition on PLA/PEG films for enhancing its antibacterial properties 35 .…”

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confidence: 99%

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Facile preparation of a novel biogenic silver-loaded Nanofilm with intrinsic anti-bacterial and oxidant scavenging activities for wound healing

Bardania

Mahmoudi

Bagheri

et al. 2020

Sci Rep

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To eliminate the microbial infection from an injury site, various modalities have been developed such as dressings and human skin substitutes. However, the high amount of reactive oxygen species, microbial infection, and damaging extracellular matrix remain as the main challenges for the wound healing process. In this study, for the first time, green synthesized silver nanoparticles (AgNPs) using Teucrium polium extract were embedded in poly lactic acid/poly ethylene glycol (PLA/PEG) film to provide absorbable wound dressing, with antioxidant and antibacterial features. The physicochemical analysis demonstrated, production of AgNPs with size approximately 32.2 nm and confirmed the presence of phytoconstituents on their surface. The antibacterial assessments exhibited a concentration-dependent sensitivity of Staphylococcus aureus and Pseudomonas aeruginosa toward biosynthesized AgNPs, which showed a suitable safety profile in human macrophage cells. Furthermore, oxidant scavenging assays demonstrated exploitation of plant extract as a reducing agent, endows antioxidant activity to biogenic AgNPs. The formation of PLA/PEG nanofilm and entrapment of AgNPs into their matrix were clearly confirmed by scanning electron microscopy. More importantly, antibacterial examination demonstrated that the introduction of biogenic AgNPs into PLA/PEG nanofibers led to complete growth inhibition of P. aeruginosa and S. aureus. In summary, the simultaneous antioxidant activity and antimicrobial activity of the novel biogenic AgNPs/PLA/PEG nanofilm showed its potential for application as wound dressing.activities of porous Ag nanofilm were investigated. We anticipate that the Ag nanofilm wound dressing with free radical scavenging capacity would enhance the wound healing process. Moreover, this study proposed a low-cost and facile method for preparation of Ag nanofilm as a potential wound dressing. Materials and MethodsMaterials. Methanol (CH 3 OH, 99.9%), silver nitrate (AgNO 3 ), nutrient agar, ferric chloride hexahydrate (FeCl 3 , 6H 2 O), iron (II) sulfate tetrahydrate (FeSO 4 .4H 2 O), dichloromethane, polyethylene glycol 300, ascorbic acid and Mueller-Hinton agar (MHA) were purchased from Merck (Germany). 2,2-diphenyl-1-picrylhydrazyl (DPPH), 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) and 2,4,6-Tripyridyl-s-Triazine (TPTZ) were purchased from Sigma (Germany) and poly lactic acid (PLA) from Zhejiang Hisun Biomaterials (China). The RAW264 macrophage cell line was purchased from National Cell Bank, Pasteur Institute of Iran, Iran and Dulbecco's Modified Eagle's Medium (DMEM), Fetal Bovine Serum (FBS), 1% Penicillin-Streptomycin from Gibco (Paisley, UK). All aqueous solutions were prepared using double distilled water. All reagents used were of analytical grade. Clinical strains of Pseudomonas aeruginosa 38 and Staphylococcus aureus 39 bacteria were isolated from hospitalized patients by our group, which have been characterized as antibiotic-resistant strains.Extract preparation. T.polium is a wild-growing...

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Section: Morphology Of Agnps Containing Nanofilmscontrasting

confidence: 99%

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confidence: 99%

Facile preparation of a novel biogenic silver-loaded Nanofilm with intrinsic anti-bacterial and oxidant scavenging activities for wound healing

Bardania

Mahmoudi

Bagheri

et al. 2020

Sci Rep

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“…Cell death is caused by electrostatic interaction between the microbial surface and MgO nanoparticles and exhibited high activity during strong interactions 21 . MgO impacted the cell wall of E. coli , which damaged the cell wall structure, causing the leakage of intracellular components and the death of bacteria cells 25,43,44 …”

Section: Resultsmentioning

confidence: 99%

Mechanical and antimicrobial properties of low‐density‐polyethylene/MgO nanocomposites

Cament

Moreno‐Serna

Loyo

et al. 2022

Polymers for Advanced Techs

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Low‐density polyethylene (LDPE) nanocomposites containing magnesium oxide (MgO) nanoparticles are obtained by melt mixing. MgO nanoparticles ca. 29 ± 2 nm are synthesized by sol–gel and organically modified on the surface with oleic acid (Mod‐MgO), whose final concentration in the polymers is 3, 5, and 10 wt%. The presence of these nanoparticles did not affect the crystallization process of LDPE. However, Young's modulus increases with 10 wt% of Mod‐MgO nanoparticles, rendering higher reinforcement effects with an increase as high as 48%. This affects the elongation at break, which decreases ca. 57% compared to neat LDPE. The storage and loss modulus of the LDPE/MgO and LDPE/Mod‐MgO nanocomposites increases at room temperature and low temperatures (−150 to −50°C) compared to neat LDPE. SEM analysis showed that the organic modification of MgO nanoparticles improved their dispersion within the polymer matrix. Nanocomposites present antimicrobial properties against Escherichia coli, reaching an efficiency ca. 53%.

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“…A series of studies have integrated the antibacterial compound to PLA/PEG film polymers for numerous purposes (Swaroop & Shukla, 2018). AgNPs embedded with polymer coats are safe for normal cells and only perform as defensive transporters or enhancers for local anti-infective effects (Bakhsheshi et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Effect of Biologically and Chemically Synthesized AgNPs on Multi-Drug Resistant (MDR) Dermatophyte Bacterial Isolates

et al. 2022

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Mechanical, Optical and Antibacterial Properties of Polylactic Acid/Polyethylene Glycol Films Reinforced with MgO Nanoparticles

Cited by 20 publications

References 15 publications

Facile preparation of a novel biogenic silver-loaded Nanofilm with intrinsic anti-bacterial and oxidant scavenging activities for wound healing

Facile preparation of a novel biogenic silver-loaded Nanofilm with intrinsic anti-bacterial and oxidant scavenging activities for wound healing

Mechanical and antimicrobial properties of low‐density‐polyethylene/MgO nanocomposites

Effect of Biologically and Chemically Synthesized AgNPs on Multi-Drug Resistant (MDR) Dermatophyte Bacterial Isolates

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