Mechanical characterization and viscoelastic model of the ovine temporomandibular joint Disc in indentation, uniaxial tension, and biaxial tension

Labus, Kevin M.; Kuiper, Jason P.; Rawlinson, Jennifer E.; Puttlitz, Christian M.

doi:10.1016/j.jmbbm.2020.104300

Cited by 12 publications

(9 citation statements)

References 45 publications

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“…Previous studies have proven that TMD is a kind of disease with complex etiology, psychological factors are considered to be closely related to it, and there is a two-way correlation between them to a certain extent [ 22 ]. In this study, the psychological status (anxiety, depression, and somatic symptoms) of 100 patients with temporomandibular disorder syndrome was compared with 100 controls without temporomandibular disorder syndrome.…”

Section: Discussionmentioning

confidence: 99%

Clinical Manifestations, Imaging Features, and Pathogenic/Prognostic Risk Factors for Temporomandibular Disorders (TMD): A Case-Control Study Based on Psychogenic Factors of Patients

Shao

Deng

2022

Computational and Mathematical Methods in Medicine

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Objective. To survey the clinical manifestations and imaging features of temporomandibular disorders (TMD) and analyze the risk factors for pathogenesis/prognosis through a case-control study based on psychogenic factors of patients. Methods. According to the inclusion criteria, 200 adult patients were randomly enrolled from the maxillofacial department of our hospital from January 2020 to May 2021, including 100 patients with TMD as the study group and 100 healthy patients as the control group. The study group can be assigned into four subgroups according to their clinical manifestations: (1) articular area or/and masticatory muscle pain group, (2) mandibular movement abnormality group, (3) joint murmur group, and (4) two or more symptom groups. Based on the study of psychogenic factors of patients, the clinical manifestations and imaging features of TMD were determined, and the risk factors for pathogenesis/prognosis were analyzed. Results. The distribution of psychological status in the TMD group was higher than that in the control group ( P < 0.05 ). The distribution of anxiety, depression, and somatic symptoms in the TMD group was significantly different from that in the control group ( P < 0.05 ). Anxiety, depression, and somatic symptoms were the risk factors for TMD. Compared with the control group, the incidence of abnormal MRI images in patients with temporomandibular disorders was significantly different ( P < 0.05 ). There were significant differences in psychological status (anxiety, depression, and somatic symptoms) among the three groups ( P < 0.05 ). Anxiety, depression, and somatic symptoms were the risk factors for abnormal mandibular movement and joint tremor and murmur ( P < 0.05 ). Somatic symptoms were the risk factors for various clinical symptoms of TMD ( P < 0.05 ). Depression was the risk factor for pain ( P < 0.05 ). Conclusion. In patients with TMD, MRI can early identify disc abnormalities and other related imaging features, which is helpful for more comprehensive clinical evaluation and treatment of TMD patients. There exhibits no significant difference in psychological status (anxiety, depression, and somatic symptoms) of patients with different clinical symptoms, and abnormal psychological status may be one of the risk factors leading to different clinical symptoms and development of different types of TMD patients.

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Section: Discussionmentioning

confidence: 99%

Clinical Manifestations, Imaging Features, and Pathogenic/Prognostic Risk Factors for Temporomandibular Disorders (TMD): A Case-Control Study Based on Psychogenic Factors of Patients

Shao

Deng

2022

Computational and Mathematical Methods in Medicine

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“…A preload of 0.5 mN was used to identify the surface of the sample, followed by a 30 s hold period before indentation. All samples were indented to a depth of 0.2 mm at a rate of 0.2 mm/s and held for a relaxation period of 100 s before tip retraction, following the protocol for previous ovine TMJ disc testing [31]. Force and displacement data were collected throughout the test.…”

Section: Indentationmentioning

confidence: 99%

“…PVA hydrogel tensile specimens were tested following the protocol previously described for ovine TMJ disc testing [31]. PVA hydrogel specimens were cut to a dog-bone shape with width 3.48 ± 0.14 mm and thickness 1.44 ± 0.10 mm (mean ± standard deviation).…”

Section: Tensile Testingmentioning

confidence: 99%

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A mechanical evaluation of polyvinyl alcohol hydrogels for temporomandibular joint disc replacement

Kuiper

Puttlitz²,

Rawlinson³

et al. 2022

Front. Phys.

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The temporomandibular joint (TMJ) is a bilateral ginglymoarthroidal joint containing a fibrocartilaginous disc which distributes compressive stress and reduces friction on the articulating surfaces of the joint. Initially, conservative treatments can address disorders of the TMJ, but surgical procedures such as discectomy may be employed if dysfunction persists. Unfortunately, discectomy increases friction and alters the mechanical behavior of the TMJ when the disc is not replaced. An ideal replacement for the TMJ disc would restore healthy function of the joint and prevent further degeneration. Rigorous evaluation of materials is necessary to ensure the safety and efficacy of novel implants. Poly(vinyl) alcohol (PVA) hydrogels have been suggested as a good candidate for artificial cartilage replacement in other applications and are promising for replacing the TMJ disc due to their biocompatibility, low friction, and biomimetic levels of hydration. The objective of this study was to mechanically characterize hydrogel formulations of 15, 20, and 25% PVA and to compare them with the ovine TMJ disc to investigate the appropriateness of PVA hydrogels for TMJ disc replacement in a translational model. Experimental evaluations were conducted in indentation, unconfined compression, friction, and uniaxial tension. There were no statistically significant differences in the coefficient of friction between the PVA hydrogels and ovine TMJ disc. No statistically significant differences were found between at least one PVA hydrogel group and the TMJ disc for the indentation properties or the unconfined compression properties at low stretch magnitudes. The 20% PVA and 25% PVA hydrogels exhibited significantly higher failure stretch as compared to the ovine TMJ disc, and they were not statistically different in ultimate tensile strength from the TMJ disc in the mediolateral direction. However, the ovine TMJ disc tensile elastic moduli were 630 times larger in the anteroposterior direction and 53 times larger in the mediolateral direction than the stiffest PVA hydrogel. Ultimately, the 25% PVA hydrogel was the best candidate for TMJ disc replacement, demonstrating the most similarity to the ovine TMJ disc compressive properties; however, tensile reinforcement of the hydrogels would be necessary to approach the tensile modulus of the native TMJ disc.

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“…Within the characterisations, it is crucial to confirm that (i) the cellular content has been removed; (ii) the structure and content of collagen and GAG has been maintained, as they are the main constituents of the disc; and (iii) the viscoelastic behaviour has not been altered, as the disc is subjected to different mechanical forces due to its translation and rotation movements. Regarding this last point, the authors believe that the first step towards unravelling the complexity of the disc’s viscoelastic behaviour should be through the use of numerical models such as non-linear or quasi-linear models [ 25 , 26 , 27 ]. This will enhance the study of bioengineered discs, such as those obtained by decellularization, since a better understanding of the load distribution in TMJ will be performed.…”

Section: A Decellularized Tmj Disc Is Not Yet Achieved But It Is Achi...mentioning

confidence: 99%

From Animal to Human: (Re)using Acellular Extracellular Matrices for Temporomandibular Disc Substitution

Trindade

Alves

Moura

2022

JFB

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Current treatments for temporomandibular joint (TMJ) disc dysfunctions are not fully effective and lack regenerative capacity. Therefore, the search for tissue-engineered materials for TMJ disc substitution is critical to fill this gap. Decellularization presents tremendous potential, as it is possible to obtain an extracellular matrix with an adequate biomechanical structure and biochemical components. However, its application to the TMJ disc is still in progress, since there are few studies in the literature, and those that exist have many gaps in terms of characterisation, which is decisive to ensure its success. Ultimately, we intend to emphasize the importance of the decellularization technique for the development of an engineered TMJ disc.

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Mechanical characterization and viscoelastic model of the ovine temporomandibular joint Disc in indentation, uniaxial tension, and biaxial tension

Cited by 12 publications

References 45 publications

Clinical Manifestations, Imaging Features, and Pathogenic/Prognostic Risk Factors for Temporomandibular Disorders (TMD): A Case-Control Study Based on Psychogenic Factors of Patients

Clinical Manifestations, Imaging Features, and Pathogenic/Prognostic Risk Factors for Temporomandibular Disorders (TMD): A Case-Control Study Based on Psychogenic Factors of Patients

A mechanical evaluation of polyvinyl alcohol hydrogels for temporomandibular joint disc replacement

From Animal to Human: (Re)using Acellular Extracellular Matrices for Temporomandibular Disc Substitution

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