Mechanical Behavior of Hydroxyapatite-Chitosan Composite: Effect of Processing Parameters

Abstract

Three-dimensional hydroxyapatite-chitosan (HA-CS) composites were formulated via solid-liquid technic and freeze-drying. The prepared composites had an apatitic nature, which was demonstrated by X-ray diffraction and Infrared spectroscopy analyses. The impact of the solid/liquid (S/L) ratio and the content and the molecular weight of the polymer on the composite mechanical strength was investigated. An increase in the S/L ratio from 0.5 to 1 resulted in an increase in the compressive strength for HA-CSL (CS low molecular weight: CSL) from 0.08 ± 0.02 to 1.95 ± 0.39 MPa and from 0.3 ± 0.06 to 2.40 ± 0.51 MPa for the HA-CSM (CS medium molecular weight: CSM). Moreover, the increase in the amount (1 to 5 wt%) and the molecular weight of the polymer increased the mechanical strength of the composite. The highest compressive strength value (up to 2.40 ± 0.51 MPa) was obtained for HA-CSM (5 wt% of CS) formulated at an S/L of 1. The dissolution tests of the HA-CS composites confirmed their cohesion and mechanical stability in an aqueous solution. Both polymer and apatite are assumed to work together, giving the synergism needed to make effective cylindrical composites, and could serve as a promising candidate for bone repair in the orthopedic field.

Biological and Physico-Chemical Properties of Composite Layers Based on Magnesium-Doped Hydroxyapatite in Chitosan Matrix

“…Namely, the adsorption peak found at 1524 cm −1 was attributed to the NH 2 groups from chitosan [ 32 , 33 ]. Furthermore, the adsorption bands of the –NH 2 group from the chitosan structure noticed at 1465 cm −1 were overlapped with the adsorption bands of the carbonate groups from the HAp [ 38 , 39 , 40 ]. In addition, the broad band from 3332 cm −1 (specific to hydroxyl groups from HAp structure), was overlapped with the adsorption bands of the –NH 2 group [ 38 , 39 , 40 ].…”

Strontium doped bioglass incorporated hydrogel-based scaffold for amplified bone tissue regeneration

“…So, optimum bioglass percentage for higher mechanical strength was 20%. In general, with considering mechanical strength of cortical (90–209 MPa) and cancellous (1.5–45 MPa) bone 63 , our fabricated scaffolds can be appropriate for bone repairing of cancellous bones.…”

Chitosan Functionalization: Covalent and Non-Covalent Interactions and Their Characterization

“…Apart from favorable physicochemical and mechanical properties, they provide ion-exchanging and adsorption properties [ 121 ]. In treatment technologies, for example, hydroxyapatite–CS material is studied for its capacity to adsorb metal ions from waste water via chelation [ 144 ]. This CS–mineral gel was reported to have a higher chelating capacity due to the high density of hydroxyl groups brought to the system by the CS backbone.…”