Mechanical Aspects of Angiogenesis

Kretschmer, Maibritt; Rüdiger, Daniel; Zahler, Stefan

doi:10.3390/cancers13194987

Cited by 69 publications

(43 citation statements)

References 121 publications

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“…The evidence proved the angiogenic impact of LIPUS on soft tissue in vitro, but this effect on bone regeneration in vivo is rarely reported. Mechanistically, it is generally acknowledged that vascularization is largely influenced by the mechanical environment (Rouwkema and Khademhosseini, 2016;Kretschmer et al, 2021). Mechanical stimuli exert both a direct impact on endothelial cells and an indirect impact on the cell response to the vascular endothelial growth factor (VEGF) gradient (Mercado-Pagán et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Low-intensity pulsed ultrasound promotes periodontal regeneration in a beagle model of furcation involvement

Wang

Xiao

Zhong

et al. 2022

Front. Bioeng. Biotechnol.

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Objective: To evaluate the regeneration potential of periodontitis tissue treated by low-intensity pulsed ultrasound (LIPUS) combined with the guided tissue regeneration (GTR) technique in a beagle model of furcation involvement (FI).Background: Achieving predictable regeneration remains a clinical challenge for periodontitis tissue due to the compromised regenerative potential caused by chronic inflammation stimulation. LIPUS, an FDA-approved therapy for long bone fracture and non-unions, has been demonstrated effective in the in vitro attenuation of inflammation-induced dysfunction of periodontal ligament stem cells (PDLSCs), the key cells contributing to periodontal regeneration. However, the in vivo effect of LIPUS on periodontitis tissue is rarely reported.Methods: A beagle model of FI was established, and the experimental teeth were randomly assigned into three groups: control group, GTR group, and GTR+LIPUS group. Radiographic examinations were performed, and clinical periodontal parameters were recorded to reflect the periodontal condition of different groups. Histological analyses using H&E and Masson’s staining were conducted to evaluate the periodontal tissue regeneration.Results: LIPUS could enhance new periodontal bone formation and bone matrix maturity in FI after GTR treatment. Moreover, clinical assessment and histomorphometric analyses revealed less inflammatory infiltration and superior vascularization within bone grafts in the LIPUS treatment group, indicating the anti-inflammatory and pro-angiogenic effects of LIPUS in FI.Conclusion: Our investigation on a large animal model demonstrated that LIPUS is a promising adjunctive approach for the regeneration of periodontitis tissue, paving a new avenue for LIPUS application in the field of periodontal regenerative medicine.

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Section: Discussionmentioning

confidence: 99%

Low-intensity pulsed ultrasound promotes periodontal regeneration in a beagle model of furcation involvement

Wang

Xiao

Zhong

et al. 2022

Front. Bioeng. Biotechnol.

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“…The decellularized vascular matrix is not only a supporting structure, but also a microenvironment for cell life. It is closely related to cell survival, regeneration, repair, and immunity (Xing et al, 2020;Kotla et al, 2021;Kretschmer et al, 2021).…”

Section: Immunological Properties Of Vascular Graftsmentioning

confidence: 99%

Application of decellularized vascular matrix in small-diameter vascular grafts

Zhou

Qiao

et al. 2023

Front. Bioeng. Biotechnol.

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Coronary artery bypass grafting (CABG) remains the most common procedure used in cardiovascular surgery for the treatment of severe coronary atherosclerotic heart disease. In coronary artery bypass grafting, small-diameter vascular grafts can potentially replace the vessels of the patient. The complete retention of the extracellular matrix, superior biocompatibility, and non-immunogenicity of the decellularized vascular matrix are unique advantages of small-diameter tissue-engineered vascular grafts. However, after vascular implantation, the decellularized vascular matrix is also subject to thrombosis and neoplastic endothelial hyperplasia, the two major problems that hinder its clinical application. The keys to improving the long-term patency of the decellularized matrix as vascular grafts include facilitating early endothelialization and avoiding intravascular thrombosis. This review article sequentially introduces six aspects of the decellularized vascular matrix as follows: design criteria of vascular grafts, components of the decellularized vascular matrix, the changing sources of the decellularized vascular matrix, the advantages and shortcomings of decellularization technologies, modification methods and the commercialization progress as well as the application prospects in small-diameter vascular grafts.

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“…In fact, angiogenesis and vasculogenesis are the predominant modes of tumor angiogenesis. Angiogenesis, the most widely investigated pattern of new vessel formation in tumors, refers to the initiation of tumor blood vessels from existing ECs and the production of new neoplastic capillaries in the format of sprouting ( 51 ). Indeed, sprouting angiogenesis is triggered by a panel of pro-angiogenic growth factors (eg.…”

Section: Manipulation Of Angiogenesis Has Pivotal Impacts On Immunosu...mentioning

confidence: 99%

Manipulation of the crosstalk between tumor angiogenesis and immunosuppression in the tumor microenvironment: Insight into the combination therapy of anti-angiogenesis and immune checkpoint blockade

et al. 2022

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Immunotherapy has been recognized as an effective and important therapeutic modality for multiple types of cancer. Nevertheless, it has been increasing recognized that clinical benefits of immunotherapy are less than expected as evidenced by the fact that only a small population of cancer patients respond favorably to immunotherapy. The structurally and functionally abnormal tumor vasculature is a hallmark of most solid tumors and contributes to an immunosuppressive microenvironment, which poses a major challenge to immunotherapy. In turn, multiple immune cell subsets have profound consequences on promoting neovascularization. Vascular normalization, a promising anti-angiogenic strategy, can enhance vascular perfusion and promote the infiltration of immune effector cells into tumors via correcting aberrant tumor blood vessels, resulting in the potentiation of immunotherapy. More interestingly, immunotherapies are prone to boost the efficacy of various anti-angiogenic therapies and/or promote the morphological and functional alterations in tumor vasculature. Therefore, immune reprograming and vascular normalization appear to be reciprocally regulated. In this review, we mainly summarize how tumor vasculature propels an immunosuppressive phenotype and how innate and adaptive immune cells modulate angiogenesis during tumor progression. We further highlight recent advances of anti-angiogenic immunotherapies in preclinical and clinical settings to solidify the concept that targeting both tumor blood vessels and immune suppressive cells provides an efficacious approach for the treatment of cancer.

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Mechanical Aspects of Angiogenesis

Cited by 69 publications

References 121 publications

Low-intensity pulsed ultrasound promotes periodontal regeneration in a beagle model of furcation involvement

Low-intensity pulsed ultrasound promotes periodontal regeneration in a beagle model of furcation involvement

Application of decellularized vascular matrix in small-diameter vascular grafts

Manipulation of the crosstalk between tumor angiogenesis and immunosuppression in the tumor microenvironment: Insight into the combination therapy of anti-angiogenesis and immune checkpoint blockade

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