2003
DOI: 10.1002/mrm.10461
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Abstract: The measurement of the arterial input function by use of gradient echo sequences was investigated by in vitro and in vivo experiments. First, calibration curves representing the influence of the concentration of Gd-DTPA on both the phase and the amplitude of the MR signal were measured in human blood by means of a slow-infusion experiment. The results showed a linear increase in the phase velocity and a quadratic increase in ⌬R* 2 as a function of the Gd-DTPA concentration. Next, the resultant calibration curv… Show more

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Cited by 171 publications
(240 citation statements)
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“…Indeed, if Eq. [3] holds and the signal-to-concentration procedure F s3c is linear, the CBF value estimated from Eq. [6] will increase by the inverse of the blood volume fraction k. Rescaling of the AIF reduces ⌬CBF, but all rescaling schemes show substantial deviations for large sampling ROIs.…”
Section: As Demonstrated Inmentioning
confidence: 99%
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“…Indeed, if Eq. [3] holds and the signal-to-concentration procedure F s3c is linear, the CBF value estimated from Eq. [6] will increase by the inverse of the blood volume fraction k. Rescaling of the AIF reduces ⌬CBF, but all rescaling schemes show substantial deviations for large sampling ROIs.…”
Section: As Demonstrated Inmentioning
confidence: 99%
“…Absolute quantification of CBF requires accurate determination of the arterial input function (AIF) (2)(3)(4)(5), defined as the concentration of contrast agent that enters the brain tissue as a function of time. In practice, the AIF is measured in a feeding artery such as the middle cerebral artery or internal carotid artery (ICA).…”
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confidence: 99%
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“…However, the vertebral artery mainly governs posterior circulation, whereas most strokes occur in the anterior regions. van Osch et al (13) developed a partial-volume correction method based on the fact that after the administration of a contrast bolus, the signal originating from blood would be linear with respect to contrast concentration in the vessel, while tissue signal would be complex and independent of contrast concentration. However, this method is only applicable when the vessel is oriented parallel to the main magnetic field (and perpendicular to the axial slice imaging plane), as is in the case of the carotid or vertebral arteries.…”
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confidence: 99%
“…The dependence between the measured ⌬R 2 * and tracer concentration is more linear for tissue signals as compared to arterial signals (10). Additionally, LRFs are less likely to suffer from AIF partial volume effect (PVE) CBF errors that occur in vivo when arterial signals are averaged with surrounding tissue influenced by complex field inhomogeneities (20). Compared to the more slowly varying tissue signals, AIFs require higher sampling rates in order to prevent introducing CBF errors through signal aliasing artifacts.…”
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confidence: 99%