Measuring Contrast Sensitivity in Specific Areas of Vision – A Meaningful Way to Assess Quality of Life and Ability to Perform Daily Activities in Glaucoma

Eshraghi, Hamoon; Sanvicente, Carina; Gogte, Priyanka; Waisbourd, Michael; Lee, Daniel; Manzi, Remy R S; Leiby, Benjamin E.; Richman, Jesse; Wizov, Sheryl S.; Spaeth, George L.

doi:10.1080/09286586.2019.1616773

Cited by 11 publications

(5 citation statements)

References 38 publications

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“…Given the association between CS and the ability to perform vision-related activities of daily living, CS measurement has been suggested as an important way to assess the visionrelated quality of life. 7,14,42 Our validation of the BCS application suggests that clinicians may use the results of remote CS testing as an excellent proxy for vision-related quality of life and visual functioning.…”

Section: Measured the Csmentioning

confidence: 90%

“…CS impairment has been proposed as an important indicator of driving skill, even among glaucoma patients with normal central visual acuity (VA) 6. Deficits in CS also correlate well with quality-of-life measures and limitations of daily activities 7…”

mentioning

confidence: 81%

“…6 Deficits in CS also correlate well with quality-of-life measures and limitations of daily activities. 7 The emergence of computer-based applications on smartphones may provide a convenient and inexpensive tool for remote ophthalmic monitoring. Of the households, 84% had access to a smartphone in 2018, and numbers continue to grow annually.…”

mentioning

confidence: 99%

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Remote Contrast Sensitivity Testing Seems to Correlate With the Degree of Glaucomatous Macular Damage

Sohail

Hirji²,

Liebmann³

et al. 2023

Journal of Glaucoma

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Précis: Remote contrast sensitivity (CS) testing through a free downloadable home test correlates with glaucomatous macular damage measured by 10-2 visual field (VF) testing.Purpose: To assess the feasibility and validity of home CS monitoring as a measure of glaucomatous damage using a free downloadable smartphone application.Methods: Twenty-six participants were asked to remotely use the Berkeley Contrast Squares (BCS) application, a free downloadable tool that records the user's CS for varying degrees of visual acuity. An instructional video detailing how to download and use the application was sent to the participants. Subjects were asked to send logarithmic CS results with a minimum 8-week test-retest window, and test-retest reliability was measured. Results were validated against office-based CS testing that was collected within the previous 6 months. Validity analysis was also carried out to determine whether CS as measured by BCS is a good predictor of 10-2 and 24-2 VF mean deviation (MD).Results: There was a high BCS test-retest reliability with an intraclass correlation coefficient score of 0.91 and a significant correlation between repeat test results and baseline test scores (Pearson, 0.86, P < 0.0001). There was significant agreement between unilateral CS scores as measured by BCS and office-based CS testing (b = 0.94, P < 0.0001, 95% CI: 0.61 to 1.27). Unilateral CS as measured by BCS was significantly associated with 10-2 VF MD (r 2 = 0.27, P = 0.006, 95% CI: 3.7 to 20.6), but not with 24-2 VF MD (P = 0.151). Conclusion:This study suggests that a free, rapid home CS test correlates with glaucomatous macular damage as measured by 10-2 VF.

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Section: Measured the Csmentioning

confidence: 90%

mentioning

confidence: 81%

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Remote Contrast Sensitivity Testing Seems to Correlate With the Degree of Glaucomatous Macular Damage

Sohail

Hirji²,

Liebmann³

et al. 2023

Journal of Glaucoma

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“…Regarding foveal CS, several studies have reported a decreased CS in patients with different stages of glaucoma (Bambo et al, 2016; Eshraghi et al, 2019; Lahav et al, 2011; Onal et al, 2008; Richman et al, 2015; Thakur et al, 2018). However, there is little evidence about CS in previous stages of POAG.…”

Section: Discussionmentioning

confidence: 99%

Contrast Sensitivity Is Impaired in Suspected Primary Open-Angle Glaucoma Patients

Tripolone,

Issolio,

Perez

et al. 2024

Preprint

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Purpose To assess contrast sensitivity (CS) for detecting visual changes in suspected POAG patients. Methods CS was measured foveally at photopic conditions and peripherally at mesopic conditions using sinusoidal gratings of 4 cycles/degree. In experiment 1, foveal and peripheral CS were assessed in suspected POAG patients and age-matched healthy control subjects. In experiment 2, foveal CS was assessed in early POAG patients age-matched with suspected POAG group. Analysis was done considering two age ranges (Under and Over 50 years of age). Correlations between CS and clinical parameters were evaluated. Results Peripheral CS was decreased only for older POAG suspect patients from the control group (Over 50: p = 0.008. Under 50: p = 0.566). Foveal CS was reduced in POAG suspect participants for both age ranges (Over 50: p = 0.028. Under 50: p < 0.001) and in early POAG patients (Under 50: p = 0.001; Over 50: p < 0.001), both compared to the control group. Foveal CS was lower in early POAG compared to POAG suspect for older patients (Over 50: p = 0.019. Under 50: p = 0.824). Foveal CS was correlated with cup-disc ratio in early POAG patients (Early: p < 0.001. Suspect: p = 0.766) and with age in both patient groups (Early: p = 0.001. Suspect: p = 0.002). Conclusion CS is affected in patients with a high risk of developing POAG and recently diagnosed. Our results suggest that CS could serve as a screening tool, detecting early damage even before structural changes occur.

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“…CS affects visual QOL. Decreased CS may suggest a visual impairment which can have negative effects on the daily lives of patients with glaucoma 4 , 5 , 13 , 14 . Visual QOL is also affected by glaucomatous VF defects.…”

Section: Discussionmentioning

confidence: 99%

Contrast sensitivity in glaucoma patients with visual field defects at different locations

Jang

Lee

2023

Sci Rep

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Contrast sensitivity (CS) is closely associated with vision-related quality of life in glaucoma patients. This cross-sectional study was performed to determine the relationship between CS and visual field (VF) sensitivity (VFS) according to the hemifield location of VF defects in 238 patients with primary open-angle glaucoma (POAG) who underwent 24-2 standard automated perimetry and CS measurement on the same day. Of the 238 eyes, 83, 58, and 47 eyes had VF defects in the superior, inferior and both hemifields, respectively, and 50 had no VF defects in either hemifield. Significant correlations between CS and VFS in all sectors were observed in the entire cohort (R2 = 0.103–0.315, all P < 0.001). However, CS poorly represented VF defects in eyes with single superior (R2 = 0.037–0.086) or inferior (R2 = 0.107–0.222) hemifield defects. Eyes with bi-hemifield VF defects showed significant correlations between VFS and CS at 0.3 m in all sectors (R2 = 0.200–0.406), but the correlation between VFS and CS at 5 m was significant only in the inferior sector (R2 = 0.224–0.348 vs. 0.081–0.126 in the inferior and superior sectors, respectively). Correlations between CS and VFS were dependent on CS distances and the presence of bi-hemifield VF defects. Although CS may not correlate with VFS in eyes with single-hemifield VF defects, it may reflect visual disability in eyes with bi-hemifield defects.

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Measuring Contrast Sensitivity in Specific Areas of Vision – A Meaningful Way to Assess Quality of Life and Ability to Perform Daily Activities in Glaucoma

Cited by 11 publications

References 38 publications

Remote Contrast Sensitivity Testing Seems to Correlate With the Degree of Glaucomatous Macular Damage

Remote Contrast Sensitivity Testing Seems to Correlate With the Degree of Glaucomatous Macular Damage

Contrast Sensitivity Is Impaired in Suspected Primary Open-Angle Glaucoma Patients

Contrast sensitivity in glaucoma patients with visual field defects at different locations

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