2019
DOI: 10.1111/acel.13080
|View full text |Cite
|
Sign up to set email alerts
|

Measuring biological aging in humans: A quest

Abstract: The global population of individuals over the age of 65 is growing at an unprecedented rate and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple chronic diseases, leading to complex drug treatments and increased risk of physical and cognitive disability. Improving or preserving the health and quality of life of these individuals is challenging due to a lack of well‐established clinical guidelines. Physicians are often forced to engage in cycles of “trial and error” that… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

4
332
1
4

Year Published

2020
2020
2024
2024

Publication Types

Select...
5
2
1

Relationship

1
7

Authors

Journals

citations
Cited by 428 publications
(378 citation statements)
references
References 289 publications
(338 reference statements)
4
332
1
4
Order By: Relevance
“…When considering the concept of aging and rejuvenation, it is important to appreciate that improved health or organ function through medication or surgery does not necessarily indicate molecular age reversal. Hence, it is conceptually challenging to test whether plasma fraction treatment, or any other putative treatment, actually reverses biological age, because there is no consensus on how to measure biological aging 11 . We addressed this challenge by using both clinical biomarkers and molecular biomarkers of aging.…”
Section: Introductionmentioning
confidence: 99%
“…When considering the concept of aging and rejuvenation, it is important to appreciate that improved health or organ function through medication or surgery does not necessarily indicate molecular age reversal. Hence, it is conceptually challenging to test whether plasma fraction treatment, or any other putative treatment, actually reverses biological age, because there is no consensus on how to measure biological aging 11 . We addressed this challenge by using both clinical biomarkers and molecular biomarkers of aging.…”
Section: Introductionmentioning
confidence: 99%
“…Finally, our group recently published a discovery proteomic analysis of skeletal muscle aging and found that mitochondrial proteins were the most important class of proteins reduced with aging (Ubaida‐Mohien et al 2019a). The mechanisms that drive the decline of mitochondrial content and function as well as resilience mechanisms that attempt to offset this decline with aging are still unclear (Ferrucci et al, ).…”
Section: Introductionmentioning
confidence: 99%
“…However, these models have limited application to the aging liver due to differences in their respective molecular and metabolic phenotypes. Since oxidative stress and mitochondrial dysfunction are considered to be critical for senescence and aging [6,11,24,25], we have developed a protocol that produces these changes to induce premature cellular senescence in nontransformed AML12 hepatic cells to study hepatic aging in vitro.…”
Section: Discussionmentioning
confidence: 99%
“…Cellular senescence in the main feature manifested in tissues of the aging organism [1,[5][6][7][8]. It is characterized by permanent cell cycle arrest, resistance to apoptosis, and a senescence-associated secretory phenotype [5].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation