Abstract:Objectives: Soft tissue sarcomas (STSs) are cancers originating in connective tissue; in 50% of cases, patients initially present with or develop advanced or metastatic disease. Prognosis is poor with standard-of-care, anthracycline-containing systemic therapy; median overall survival (OS) is approximately 1 year. A recent phase 2 trial investigated olaratumab, a human anti-platelet-derived growth factor receptor alpha monoclonal antibody, in combination with doxorubicin, for treatment of advanced STS (aSTS). … Show more
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