Measurements of lenticulostriate arteries using 7T MRI: new imaging markers for subcortical vascular dementia

Seo, Sang Won; Kang, Chang-Ki; Kim, Sook Hui; Yoon, Doo Sang; Liao, Wei; Wörz, Stefan; Rohr, Karl; Kim, Young-Bo; Na, Duk L.; Cho, Zang-Hee

doi:10.1016/j.jns.2012.05.032

Cited by 38 publications

(22 citation statements)

References 24 publications

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“…Their topography corresponds to the vascular territory of the lenticulostriate arteries [5]. These findings correlate well with "in vivo" measurements of lenticulostriate arteries using 7-tesla MRI that show fewer side-branches in VaD [24].…”

supporting

confidence: 78%

Frequency and topography of small cerebrovascular lesions in vascular and in mixed dementia: a post-mortem 7-tesla magnetic resonance imaging study with neuropathological correlates

Reuck¹,

Auger²,

Durieux³

et al. 2017

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supporting

confidence: 78%

Frequency and topography of small cerebrovascular lesions in vascular and in mixed dementia: a post-mortem 7-tesla magnetic resonance imaging study with neuropathological correlates

Reuck¹,

Auger²,

Durieux³

et al. 2017

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“…Due to the longer T 1 , spins in static tissue show decreased relaxation in between the radiofrequency pulses, resulting in lower signal of static tissue [9]. Different studies already demonstrated the benefits of 7T for TOF-MRA in the visualization of intracranial small vessels [8, 10–21]. …”

Section: Introductionmentioning

confidence: 99%

“…In previous reports, 7T MRI has been shown to be capable of visualizing the lenticulostriate arteries [13, 15, 17–21], perforating arteries originating from the posterior communicating artery (PCoA) [14], and basilar artery (BA) perforators [16]. These previous studies, in which each individual study focused on the visualization of one type of perforators only, were performed using TOF-MRA techniques without contrast administration.…”

Section: Introductionmentioning

confidence: 99%

High-Resolution Postcontrast Time-of-Flight MR Angiography of Intracranial Perforators at 7.0 Tesla

et al. 2015

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Background and PurposeDifferent studies already demonstrated the benefits of 7T for precontrast TOF-MRA in the visualization of intracranial small vessels. The aim of this study was to assess the performance of high-resolution 7T TOF-MRA after the administration of a gadolinium-based contrast agent in visualizing intracranial perforating arteries.Materials and MethodsTen consecutive patients (7 male; mean age, 50.4 ± 9.9 years) who received TOF-MRA at 7T after contrast administration were retrospectively included in this study. Intracranial perforating arteries, branching from the parent arteries of the circle of Willis, were identified on all TOF-MRA images. Provided a TOF-MRA before contrast administration was present, a direct comparison between pre- and postcontrast TOF-MRA was made.ResultsIt was possible to visualize intracranial perforating arteries branching off from the entire circle of Willis, and their proximal branches. The posterior cerebral artery (P1 and proximal segment of P2) appeared to have the largest number of visible perforating branches (mean of 5.1 in each patient, with a range of 2–7). The basilar artery and middle cerebral artery (M1 and proximal segment M2) followed with a mean number of 5.0 and 3.5 visible perforating branches (range of 1–9 and 1–8, respectively). Venous contamination in the postcontrast scans sometimes made it difficult to discern the arterial or venous nature of a vessel.ConclusionHigh-resolution postcontrast TOF-MRA at 7T was able to visualize multiple intracranial perforators branching off from various parts of the circle of Willis and proximal intracranial arteries. Although confirmation in a larger study is needed, the administration of a contrast agent for high-resolution TOF-MRA at 7T seems to enable a better visualization of the distal segment of certain intracranial perforators.

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“…7T TOF-MRA is now available for assessing the BPAs in living human brains [19][20][21][22][23][24] . Its obvious advantages, such as significantly higher signal-to-noise ratio over lower magnetic fields (3T or below), have been previously reported [30] .…”

Section: Discussionmentioning

confidence: 99%

“…Although the lenticulostriate arteries have been studied using various neuroimaging methods [17][18][19][20] , identification of smaller BPAs, such as distal segments or branches of the AchoA and PCA, remains a challenge [21][22][23][24] .…”

Section: Introductionmentioning

confidence: 99%

The Posterior Limb of the Internal Capsule as the Subcortical Transitional Zone of the Anterior and Posterior Circulations: Insights from Human 7T MRI

Kurabe

Okamoto²,

Suzuki³

et al. 2016

Cerebrovasc Dis

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Background: In patients with cerebral infarction, identifying the distribution of infarction and the relevant artery is essential for ascertaining the underlying vascular pathophysiological mechanisms and preventing subsequent stroke. However, visualization of the basal perforating arteries (BPAs) has had limited success, and simultaneous viewing of background anatomical structures has only rarely been attempted in living human brains. Our study aimed at identifying the BPAs with 7T MRI and evaluating their distribution in the subcortical structures, thereby showing the clinical significance of the technique. Methods: Twenty healthy subjects and 1 patient with cerebral infarction involving the posterior limb of the internal capsule (ICpost) and thalamus underwent 3-dimensional fast spoiled gradient-echo sequence as time-of-flight magnetic resonance angiography (MRA) at 7T with a submillimeter resolution. The MRA was modified to detect inflow signals from BPAs, while preserving the background anatomical signals. BPA stems and branches in the subcortical structures and their origins were identified on images, using partial maximum intensity projection in 3 dimensions. Results: A branch of the left posterior cerebral artery (PCA) in the patient ran through both the infarcted thalamus and ICpost and was clearly the relevant artery. In 40 intact hemispheres in healthy subjects, 571 stems and 1,421 branches of BPAs were detected in the subcortical structures. No significant differences in the numbers of stems and branches were observed between the intact hemispheres. The numbers deviated even less across subjects. The distribution analysis showed that the subcortical structures of the telencephalon, such as the caudate nucleus, anterior limb of the internal capsule, and lenticular nucleus, were predominantly supplied by BPAs from the anterior circulation. In contrast, the thalamus, belonging to the diencephalon, was mostly fed by BPAs from the posterior circulation. However, compared with other subcortical structures, the ICpost, which marks the anatomical boundary between the telencephalon and the diencephalon, was supplied by BPAs with significantly more diverse origins. These BPAs originated from the internal carotid artery (23.1%), middle cerebral artery (38.5%), PCA (17.3%), and the posterior communicating artery (21.1%). Conclusions: The modified MRI method allowed the detection of the relevant BPA within the infarcted area in the stroke survivor as well as the BPAs in the subcortical structures of living human brains. Based on in vivo BPA distribution analyses, the ICpost is the transitional zone of the anterior and posterior cerebral circulations.

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Measurements of lenticulostriate arteries using 7T MRI: new imaging markers for subcortical vascular dementia

Cited by 38 publications

References 24 publications

Frequency and topography of small cerebrovascular lesions in vascular and in mixed dementia: a post-mortem 7-tesla magnetic resonance imaging study with neuropathological correlates

Frequency and topography of small cerebrovascular lesions in vascular and in mixed dementia: a post-mortem 7-tesla magnetic resonance imaging study with neuropathological correlates

High-Resolution Postcontrast Time-of-Flight MR Angiography of Intracranial Perforators at 7.0 Tesla

The Posterior Limb of the Internal Capsule as the Subcortical Transitional Zone of the Anterior and Posterior Circulations: Insights from Human 7T MRI

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